Uses of Moxetumomab Pasudotox - tdfk

Moxetumomab is a drug that works by binding to CD22 on the surface of B cells. It inhibits protein synthesis in cancer cells, rendering cancer cells non-viable.

Moxetumomab is produced in the form of an infusion solution, so it is given into the patient's body by intravenous infusion. Dosage and frequency of administration vary from patient to patient, depending on body weight and tolerability. In particular, before, during, and after infusion, the patient's body must maintain proper hydration. The patient will receive intravenous fluids before and after the infusion.
Patients will be instructed to take low-dose aspirin at certain times to prevent blood clots from forming. The patient will be given acetaminophen, an antihistamine, and an H2-receptor blocker to prevent a reaction to the drug Moxetumomab.
Before receiving the drug and during the treatment, the patient should be checked the electrolyte values.
After the infusion, the patient may also be given medication to further prevent the reaction and reduce the feeling of nausea and vomiting.

During drug treatment, patients may experience some side effects with varying frequency. However, there are some things you can do to manage those side effects.
Capillary leak syndrome: Blood and blood components escape from capillaries and into body cavities and muscles. This blood loss can cause low blood pressure and organ failure. Signs and symptoms of this syndrome include: a sudden drop in blood pressure, weakness, fatigue, swelling of the hands, feet, and other parts of the body, nausea, cough, shortness of breath, and dizziness. Hemolytic uremic syndrome: The drug can destroy red blood cells, damage blood vessels, and possibly lead to kidney failure. When there is unusual bruising or bleeding, the amount of urine decreases, the patient may have this syndrome. Infusion-related side effects: Intravenous infusion of drugs may cause reactions leading to chills, cough, dizziness, shortness of breath, feeling hot, headache, hypertension, hypotension. , infusion-related reactions, myalgia, nausea, high fever, tachycardia, vomiting, and wheezing. Electrolyte disorders: The drug affects electrolytes such as calcium, phosphate, ... in the body. Patients should have their electrolyte levels checked regularly with blood tests. In case the electrolyte level is too low, the doctor may prescribe the patient to drink or intravenously infuse electrolytes. Decreased red blood cell count (anemia): Medications used to treat it can reduce the number of red blood cells causing anemia. At that time, the body lacks oxygen leading to fatigue, weakness, shortness of breath, chest pain. In case the number of red blood cells decreases a lot, the body is anemic, the patient may be assigned a blood transfusion to make up for the lost blood volume and restore the patient's health. Low white blood cell count: In this case, the patient's body is very susceptible to infection. If symptoms such as fever, cough, sore throat, cold, etc. appear, the patient should immediately notify the doctor for proper treatment. To limit infection, patients and their family members need to regularly wash their hands, clean the living environment, avoid crowded contact, especially sick people,... affect the kidneys: Using drugs that increase creatinine levels, affecting the function of the kidneys. Patients may have blood in the urine, decreased urine output, loss of appetite, swollen ankles,... Drugs affecting liver function: It is necessary to periodically check liver function tests for people. sick. When liver function is impaired, patients may experience symptoms such as yellowing of the skin, eyes, dark urine, abdominal pain,... Signs of edema: Using drugs to increase water retention in the body leading to swelling of the extremities, signs of edema. The medicine may cause swelling of the hands, arms, legs, ankles, and feet. At the site of the patient's swelling may become uncomfortable. Feeling nauseous and vomiting: Patients need to inform their doctor about their condition so that the doctor can promptly adjust. Medications may be used to help control nausea and vomiting. In addition, the patient can change the diet, create an appetite, use salt water or ginger to relieve symptoms. Fatigue: This is a common sign of cancer treatment and often does not improve with rest. Patients should exercise, walk, plan rest to ensure health. Headache: Patients can take medication to relieve pain as prescribed by the doctor. Constipation: Increase fiber in your diet, drink the recommended amount of water each day, and stay active. In addition, patients can use stool softeners to relieve constipation. However, the drugs used should be consulted by a doctor. Decreased platelet count: When the platelet count decreases, the risk of bleeding increases. When bruises, nosebleeds, bleeding gums, blood in urine and stools appear, the patient should immediately contact a doctor for proper treatment. May experience diarrhea: Patients should use foods rich in fiber such as apples, bananas, white rice, oatmeal, potatoes. Besides, the patient can take medicine to reduce diarrhea according to the doctor's prescription.

Using the drug can cause birth defects in the fetus, so the patient should not become pregnant or father when using the drug to treat the disease.
Patients need to stop taking the drug at least 30 days after treatment if they intend to become pregnant and give birth. While taking the drug, the patient needs effective birth control.
Moxetumomab may be excreted in breast milk. Therefore, if the mother is taking the drug, she should stop breastfeeding or breast-feeding, then the drug should not be used to ensure the safety of the baby.
The drug Moxetumomab pasudotox - tdfk is a drug that inhibits the protein synthesis of cancer cells, preventing them from growing and spreading. The drug is only used when prescribed by a doctor and is infused into the patient's body by medical staff. Depending on the condition and frequency of use, the drug causes unwanted effects with varying degrees and frequencies. Patients should strictly follow the doctor's instructions, absolutely do not self-medicate for the treatment process to be highly effective and safe.
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Reference source: oncolink.org