Vancomycin is the first glycopeptide antibiotic isolated from Amycolatopsis orientalis in the mid-1950s. In 1958, vancomycin was used clinically to treat penicillin-resistant Staphylococcus aureus. However, a few years later, this antibiotic was no longer preferred due to the appearance of many toxicity due to the impure preparation. After changing the manufacturing process to improve the purity of the preparation, vancomycin was again widely used since the 1980s.