Oxycodone/Aspirin contains 2 types of pain relievers, Oxycodone and Aspirin. Oxycodone is an opioid or narcotic pain reliever that works on certain parts of the brain to relieve pain. Aspirin is known as a salicylate and a non-steroidal anti-inflammatory drug (NSAID). It works by blocking a certain natural substance in your body that reduces pain and swelling. What is the use of Oxycodone/Aspirin (Percodan)?