Stickler syndrome is a group of genetic conditions characterized by distinctive facial features, eye abnormalities, hearing loss, and joint problems. A characteristic feature of Stickler syndrome is a somewhat flat face. This appearance is due to underdeveloped bones in the midface, including the cheekbones and bridge of the nose. A specific group of physical features called Pierre Robin syndrome is also common in people with Stickler syndrome. Problems with the bones of the spine can also occur, including abnormal curvature of the spine (scoliosis) and flattened vertebrae (spondylosis). Researchers have described several types of Stickler syndrome, distinguished by their genetic causes, signs, and symptoms. In this article, we will provide useful information to better understand Stickler syndrome.