Anti-sperm antibodies are one of the causes of male infertility. Anti-sperm antibodies appear in the body and hinder the fertilization process, formation of complexes, or affect the development of the fetus, in some cases causing miscarriage.

About 13 out of 100 couples fail to get pregnant from unprotected sex. In more than one-third of infertility cases, the problem is with the man. This is usually due to problems with sperm production or problems with the sperm reaching the egg.