Histopathological and cytological biopsy is a medical procedure performed quite commonly today, but most patients and family members rarely understand the importance and significance of this procedure before proceeding. . This is the most accurate disease assessment method that provides information at the tissue and cellular level, when methods such as tests, ultrasound, endoscopy,... do not bring enough information to make a definitive diagnosis. and monitor disease progression. And especially with cancers, histopathological diagnosis is a mandatory indication.