Implantation failure and early miscarriage after in vitro fertilization (IVF) are mainly caused by abnormalities in the number of chromosomes. The rate of embryos with abnormalities in the number of chromosomes increases with maternal age, accounting for 35% in women aged 35 and can be up to 60% in women aged 40. To solve this problem, pre-implantation embryo screening techniques were born to help doctors select embryos without genetic abnormalities, thereby increasing the success rate of IVF.

Pre-implantation genetic testing for aneuploidy (PGT-A) is a genetic test performed on one or a few cells of the embryo to determine genetic abnormalities at the chromosomal level, thereby selecting the best embryo before embryo transfer.