Plasmapheresis (TPE) is a blood separation method that aims to remove large molecules such as autoantibodies, immune complexes, immunoglobulins, endotoxins or lipoproteins... Removing these substances aims to improve the clinical manifestations of the disease. In addition, TPE also helps activate lymphocytes to control cytotoxicity, supplement beneficial proteins such as albumin, coagulation factors, to improve coagulation disorders[34].