Hand-foot syndrome, also known as Palmar-Plantar Erythrodysesthesia, is a side effect that can occur with certain chemotherapy or biologic drugs used to treat cancer. For example, Capecitabine (Xeloda®), 5-Flurouracil (5FU), continuous infusion doxorubicin, liposomal doxorubicin (Doxil®), and high-dose Interleukin-2.