Vomiting in infants is a fairly common symptom, it occurs due to the amount of food in the stomach being pushed up the esophagus and out of the mouth. Frequent vomiting will affect eating activities and can cause the baby to lose appetite. This is also one of the causes that can lead to malnutrition in children.

In gastroesophageal reflux disease in children, immature lower esophageal sphincter function is manifested by frequent transient relaxation of the lower esophageal sphincter, leading to the appearance of backflow of gastric contents into the esophagus.