Lupus nephritis is a condition that occurs when the kidneys become inflamed. This is one of the most common complications in people with systemic lupus erythematosus, and in severe cases can lead to chronic kidney failure.

Lupus-related kidney inflammation, also known as lupus nephritis, can cause long-term effects, ranging from benign lesions of unknown cause to more serious damage, including kidney failure. Early diagnosis and prompt treatment can help prevent the disease from progressing.

With lupus, the body's immune system attacks its own tissues. Up to 60% of people with lupus will develop lupus nephritis, which occurs when lupus autoantibodies attack structures inside the kidneys that filter waste.