Flixonase nasal spray contains the main ingredient Fluticasone propionate. This is a corticosteroid (also known as a steroid) drug. Nasal steroids work to reduce inflammation, swelling and irritation in the nose. Therefore, Flixonase spray helps relieve nasal itching, sneezing, nasal congestion and runny nose. Flixonase spray is used to prevent and treat seasonal allergic rhinitis (such as pollen allergies) and perennial allergic rhinitis (such as dog and cat allergies).