Pre-implantation genetic testing for monogenic disease (PGT-M) is a genetic test performed on embryos to reduce the risk of pregnancy with a monogenic genetic abnormality in high-risk parents.

Thalassemia is an autosomal recessive genetic disease. Thalassemia is divided into two main types: alpha and beta thalassemia, depending on which gene mutation causes deficiency in the synthesis of alpha or beta hemoglobin chains.