Injury to the spine due to metastatic cancer is a common complication in cancer patients, which can cause pain and loss of nerve function. Most tumors metastasize to the vertebral body and grow outside the spinal cord. Early detection of bone metastases and early treatment aim to restore nerve function, treat pain, and prevent future neurological complications.

Pain from cancer metastasis to bone is a chronic pain condition with complex pathogenesis and impact on physical, psychological and daily activities of cancer patients. Over the years, many different modalities of pain treatment for bone metastases have been tested and certain achievements have been achieved. These methods are presented in turn as follows: