Aggressive supportive care, including appropriate stimulation of leukocyte production, is important in the treatment of acute colchicine toxicity. In particular, treatment with specific antibodies appears to be effective but is not widely used, poorly studied, and not currently commercially available.

Colchicine poisoning is uncommon but very severe and has a high mortality rate. The disease can be easily overlooked because the gastrointestinal manifestations can mimic other systemic diseases.