Continuous venovenous hemofiltration (CVVH) is a blood filtration technique that allows continuous (> 12 hours) removal of water and solutes with a molecular weight of less than 50,000 daltons from the patient's blood. In particular, with a large volume of replacement fluid (≥ 35ml/kg/hour) through a convection mechanism, it helps to effectively remove solutes with an average molecular weight similar to that of pro-inflammatory substances.