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Zebacef medicine 300mg has the main active ingredient is Cefdinir and other excipients in a sufficient amount. This medicine is used in the treatment of diseases such as pneumonia, chronic bronchitis, sinusitis, pharyngitis, tonsillitis.1. What is Zebacef 300mg?
Drug group: Zebacef 300mg belongs to the group of drugs to treat parasites, treat bacterial infections, antivirals, antifungals. Dosage form is: Film-coated tablets Packing: Box of 1 blister x 10 tablets Ingredients: Active ingredient Cefdinir 300mg content and other excipients with a sufficient amount of 1 tablet. 1.1. Pharmacodynamics of the drug Zebacef 300mg: Pharmaceutical substance Cefdinir is a 3rd generation oral cephalosporin with a broad spectrum of activity against many Gram-negative and Gram-positive aerobic bacteria.
1.2. Pharmacokinetics of the drug Zebacef 300mg: Absorption: The drug Cefdinir is poorly absorbed from the gastrointestinal tract, only for parenteral use. Distribution: Widely distributed in tissues and body fluids, penetrates well into the cerebrospinal fluid. Metabolism and Elimination: The drug is metabolised in the liver and eliminated mainly by the kidneys. 1.3. The effect of the drug Zebacef 300mg Pharmaceutical substance Cefdinir is an antibiotic with a cephem nucleus, with a vinyl group at the 3rd position and a 2-aminothiazoly hydroxyimino group at the 7th position of the active ingredient 7-aminocephalosporanic acid. Cefdinir is not affected by beta-lactamase enzymes, has broad antibacterial activity against gram(-) and gram(+) bacteria. In particular, it is effective against gram (+) bacteria such as Staphylococcus sp., Streptococcus sp., which are resistant to other pre-existing oral cephalosporin antibiotics. Cefdinir is a bactericidal drug with balanced bactericidal activity against gram (-) and gram (+) bacteria.
Mechanism of action:
The mechanism of action of Cefdinir is inhibition of cell wall synthesis. The drug has a high affinity for penicillin-binding proteins (PBPs) 1 (1a, 1bs), 2 and 3, with variable sites of action depending on the type of bacteria.
2. What diseases does Zebacef 300mg treat?
Zebacef 300mg medicine is used for the following mild and moderate infections:
For adults and adolescents 12 years of age and older: Community acquired pneumonia and acute exacerbation of chronic bronchitis . Pharyngitis or tonsillitis. Uncomplicated skin and skin structure infections. For children under 12 years: Not recommended, recommend to use as a suspension.
3. Adverse effects of Zebacef 300mg
Common adverse effects, including:
For the digestive system: Digestive disorders, diarrhea, nausea, abdominal pain. For the nervous system: Headache. For the genitourinary system: Vaginitis , Vaginitis caused by Monilia in women. Uncommon side effects include:
For digestion: Abnormal stools, dyspepsia, constipation, dry mouth, flatulence, vomiting, anorexia, pseudomembranous colitis. Skin: Rash or rash. For the genitourinary system: Leukemia in women. For the nervous system: Dizziness, insomnia, when sleeping or dreaming. Body as a whole: Weakness. If you see any unwanted effects, immediately notify the treating doctor or qualified medical professionals for timely treatment.
4. Interactions of drugs Zebacef 300mg
Several interactions with Zebacef 300mg have been reported, including:
Aluminum or magnesium antacids, iron supplements and foods fortified with iron: Decreased absorption of Cefdinir. If it is necessary to take Zebacef 300mg together with these drugs, you should take Cefdinir 2 hours before or 2 hours after taking the iron and antacid. Probenecid: Will increase the absorption, concentration and activity of the active ingredient Cefdinir in the blood. False positive for Ketone in urine when tested using Nitroprusside. False positive for Glucose in urine when using Benedict or Fehling's solution. Occasionally a positive Coombs test can be produced. To ensure safety and effectiveness, you need to actively inform your treating doctor about all medicines, health foods you are using and other diseases you are having.
5. Some notes when using Zebacef 300mg
5.1 Notes and cautions when using Zebacef 300mg Drug-resistant bacteria are increasing, you need to pay attention to use antibiotics containing the active ingredient Cefdinir accordingly, to avoid causing drug resistance. For people with renal impairment, you should evaluate kidney function before taking the drug. When the glomerular filtration rate is less than 30 ml/min, the doctor will prescribe a dose reduction. During the treatment with Zebacef 300mg, you encounter one of the undesirable effects, you need to see a doctor immediately for appropriate treatment. You should use the medicine at the correct dose every day as directed by your doctor, avoiding underuse or overdose. If you use an overdose and have symptoms of nausea, vomiting, etc., please see a doctor immediately for timely treatment. 5.2. Note to other special populations For pregnant women: There are no adequate and well-controlled studies in pregnant women. You should only use Zebacef 300mg in case of absolute necessity, with the prescription of a doctor. For nursing mothers: Use a single dose of 600 mg/day without Cefdinir in breast milk. However, you should consult your doctor before taking it during this time. For drivers and machine operators: Undesirable effects of Zebacef 300mg cause headache, dizziness, affecting the ability to drive and use machines. Use caution when using Zebacef 300mg in this case. 5.3. Other Special Precautions Prolonged use of Zebacef 300mg may result in an overgrowth of Clostridium difficile bacteria. Adverse effects of colitis and pseudomembranous colitis have been reported, ranging from mild to life-threatening. Use caution when using Zebacef 300mg in case of a history of colitis, impaired renal function in the elderly, history of allergy to penicillin. Do not use in combination with any other preparations containing the active ingredient Cefdinir. 5.4. Storage conditions Zebacef 300mg Drug storage temperature is below 30 degrees C. Avoid exposure to direct sunlight. Keep out of sight and reach of children or household pets. Do not use Zebacef 300mg after the expiry date printed on the package. Above is the complete information about the drug Zebacef 300mg. You need to read the user manual carefully before using it.
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