What is Topralsin used for?

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Topralsin is used in the symptomatic treatment of dry cough in adults and children over 1 year of age. The drug contains the main ingredients including Oxomemazine, Guaifenesin, Paracetamol and Sodium benzoate.

1. What is Topralsin?

1.1. Pharmacokinetics of the drug Topralsin Topralsin is a hard capsule containing many active ingredients. Topralsin is used to treat and prevent dry cough, especially nocturnal cough, in adults and children over 1 year of age.
The main ingredients in Topralsin drugs include:
Oxomemazine Is a derivative of the dimethylaminopropyl phenothiazine group, has antihistamine effects and strong sedative effects. Similar to other H1-antihistamines, Oxomemazine competes with histamine for H1-receptor sites on effector cells, but has no effect on blocking histamine release, so the drug only plays a role. Prevents reactions caused by histamine including: rash or hives on the surface of the skin.
Active ingredient Oxomemazine completely antagonizes histamine in tracheal smooth muscle, digestion causes relaxation of these muscles and partially antagonizes the cardiovascular system causing reduced capillary permeability. Oxomemazine is not capable of inhibiting gastric secretion. Oxomemazine causes orthostatic hypotension in people with a predisposition to the drug.
At therapeutic doses, the drug can cause paradoxical stimulation or inhibition of the central nervous system. The central nervous system stimulant effect is characterized by signs such as restlessness, irritability, difficulty sleeping. The CNS depressant effect is characterized by clinical signs such as decreased agility, slow reactions or somnolence.
Guaifenesin Has good effect in respiratory tract antiseptic.
Paracetamol This is a drug belonging to the group of antipyretic, analgesic, non-steroidal anti-inflammatory drugs (NSAIDs). The drug has a good effect in lowering body temperature in people with fever, rarely in normal people. Drugs acting on the hypothalamus cause hypothermia, increased heat loss due to vasodilation and increased peripheral blood flow. At therapeutic doses, the drug has no undesirable effects. However, when using Paracetamol in large doses, the drug is capable of converting into N-acetyl-benzoquinonimin, a substance that is highly toxic to the liver.
Sodium benzoate This active ingredient has a stimulating effect on bronchial secretion.

1.2. Pharmacokinetics of the drug Topralsin Active ingredient Paracetamol is almost completely absorbed from the gastrointestinal tract. The drug is evenly distributed in most tissues of the body, 25% of paracetamol in the blood is bound to plasma proteins. The ability to eliminate 90 - 100% of the drug in the urine on the first day, mainly after conjugation in the liver with glucuronic acid (about 60%), sulfuric acid (about 35%) or cysteine ​​(about 3%) was also detected. small amounts of hydroxylated and deacetylated metabolites.
1.3. Indications to use Topralsin The drug is indicated in the symptomatic treatment of dry cough, especially nocturnal cough in adults and children over 1 year old.

2. Undesirable effects of the drug Topralsin

Undesirable effects of active ingredient Oxomemazine:
Common undesirable effects are fatigue, drowsiness, increased consistency of bronchial secretions, dry mouth, constipation, urinary retention, dizziness, nausea; Rarely, such as anorexia, nausea, vomiting, diarrhea; Very rare: Tardive dyskinesia due to prolonged use of antiallergic drugs, leukopenia and agranulocytosis, irritability in infants and nursing infants. Undesirable effects of Guaifenesin:
Less common: Diarrhea, dizziness, headache, nausea, abdominal pain, skin rash; Rarely, such as tachycardia, atrial fibrillation, supraventricular tachycardia, and extrasystoles in patients with a drug-sensitive state. Paracetamol causes the following undesirable effects:
Uncommon: Skin rash, nausea, vomiting, hematopoietic disorders, anemia. Kidney disease, nephrotoxicity when using the drug for a long time. Rare: Hypersensitivity reactions. You should contact your doctor immediately if you have any health problems while using Topralsin.

3. How to use and dose Topralsin

How to use Topralsin:
Take Topralsin with filtered or boiled water; Short-term treatment for a few days should be strictly prescribed by the treating doctor. Dosage of Topralsin:
For adults: Take 2-6 tablets/day, divided into 2-3 times a day; For children: Use as directed and directed by a doctor. 4. Topralsin drug overdose Symptoms of Topralsin drug overdose:
In children: Nervous disorders such as excitement, agitation, hallucinations, dancing, convulsions, fixed and dilated pupils, facial skin flushing and high fever. Severe coma with cardiovascular collapse may eventually occur, and death may occur within 2 to 98 hours. In adults: Psychosis, depression, and coma may precede episodes of agitation and convulsions. How to handle an overdose of Topralsin: Contact and immediately go to the nearest medical facility. Doctors can prescribe symptomatic treatment, can support breathing, artificial respiration with the use of anticonvulsants.

5. Topralsin drug interactions

Topralsin has many interactions with other medications. So you need to inform the treating doctor when you are using drugs such as:
Levodopa, Guanethidine, Zidovudine and other drugs of the same class; Group of salts, oxides, hydroxides of Mg, Al, Ca; Antihypertensive drugs: Nifedipine, Amlodipine, Captopril, Furosemide,...; Atropine and similar active substances; Drugs that cause depression with the nervous system. Food, tobacco, and alcohol can interact with certain medications. Therefore, you need to consult with your doctor about the general use of these drugs.
6. Some notes when treating with Topralsin There are no reports of safety when using the drug in pregnant and lactating women. Therefore, Topralsin should not be used in these groups of people.
Topralsin can cause dizziness and drowsiness, so it should be avoided by people who are driving or operating machinery.
How to store Topralsin:
Keep the medicine in the container, out of the reach of children and pets in the house; Store Topralsin in a dry place at a temperature between 15 - 30 °C. Avoid direct light; Avoid storing Topralsin in a humid place such as the bathroom or the freezer compartment. Expired Topralsin must not be used and these drugs must be treated before being released into the environment. Topralsin is a brand name drug that includes a variety of active ingredients used to prevent and treat dry cough, especially a cough that is much at night. However, the drug has many side effects and interactions, you should follow the instructions of the treating doctor to ensure safety.

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