What is Rinofil?

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Rinofil belongs to the group of antiallergic drugs, which are used to treat and relieve symptoms of allergic rhinitis or chronic idiopathic urticaria. Medicines can promote optimal therapeutic effects when used correctly and in the right dose as directed by the doctor.

1. What is Rinofil syrup?

Rinofil is an antiallergic drug, prepared in the form of a syrup and manufactured by Laboratorios Recalcine S.A. Rinofil medicine is packaged in a box of 1 bottle of 15ml or 100ml. Each 5ml of Rinofil solution contains the following active ingredients and excipients:
Main active ingredient: Desloratadin 2.5mg. Other excipients just 5ml: anhydrous citric acid, propylene glycol, sodium citrate dihydrate, glycerol, sodium methylparaben, hydroxyethylcellulose, sodium propylparaben, sucralose, apricot essential oil, caramel mou essence, sorbitol 70% and purified water.

2. Indications and uses of Rinofil

2.1. Indications for the use of Rinofil

In addition to learning what Rinofil is, you also need to know the following drug indications:
Rinofil syrup is indicated for children over 6 months old and adults with allergic conditions. Treatment of nasal symptoms or associated with seasonal allergic rhinitis in patients over 2 years of age. Rinofil is indicated for the rapid relief of symptoms caused by perennial allergic rhinitis in patients over 6 months of age. Treatment and relief of pruritus, number and size of rash in patients over 6 months of age with chronic idiopathic urticaria.

2.2. Mechanism of action and uses of Rinofil

The main ingredient desloratadine in Rinofil is a selective, long-acting tricyclic histamine H1 receptor blocker that inhibits the release of histamine from mast cells. After oral administration, desloratadine does not enter the central nervous system, thereby selectively inhibiting peripheral histamine H1 receptors.
According to the results of in vitro studies, the active ingredient desloratadine in Rinofil provides antiallergic effects thanks to its ability to inhibit the release of pro-inflammatory cytokines, including IL-4, IL-6, IL-8 and IL -13 from basophils or mast cells. In addition, the antiallergic effect of Rinofil is also based on the inhibition of adhesion molecules expressed in the endothelial membrane, namely P-Selectin.
Approximately 30 minutes after oral administration of Rinofil, plasma desloratadine concentrations can be detected in both adolescent and adult patients. Approximately 3 hours after oral administration, the active substance reaches peak plasma concentrations and is well absorbed, with a terminal elimination half-life of approximately 27 hours. The bioavailability of the active ingredient desloratadine in the drug will be proportional to the dose from 5 to 20 mg.
According to studies, up to 82-87% of desloratadine is bound to plasma proteins. After absorption, the active substance is metabolized to 3-hydroxy desloratadine and further conjugated with glucuronic acid.

3. Dosage and how to use Rinofil

3.1. Dosage of Rinofil

Rinofil dosage will be determined specifically based on the age of each patient, including:
Usual Rinofil dose for children > 12 years old and adults: Take 10ml, equivalent to 5mg / time / day. Usual Rinofil dose for children from 2 to 5 years old: Take 2.5ml, equivalent to 1.25mg / time / day. Usual Rinofil dose for children from 6 to 11 years old: Take 5ml, equivalent to 2.5mg / time / day. Usual Rinofil dose for children from 6 to 11 months old: Take 2ml, equivalent to 1mg / time / day. Initial dose of Rinofil for patients with impaired renal or hepatic function: 5 mg every other day.

3.2. How to use Rinofil

Because Rinofil is in the form of a syrup, it can be taken orally by the patient. When using, you should measure with a dropper, a milliliter cap or a syringe to get the solution according to the dose prescribed by the doctor. Rinofil medicine can be taken directly with food or taken away from meals depending on the needs of each individual.
In addition, patients also need to carefully read the instructions for using Rinofil before using, and discuss with their doctor if they do not know any information related to the use and dosage of the drug.

4. How to handle when taking an overdose or forgetting a dose of Rinofil

4.1. In case of overdose of Rinofil

Although there have not been any reports of serious effects after using doses of Rinofil up to 45mg (9 times the usual dose), however, when there is suspicion or the body has reactions occurring after taking medicine, you need to notify or contact your doctor immediately. The treatment of overdose will require the application of measures to help remove the active substance that has not been absorbed outside the body. In addition, the patient also received supportive therapy or took symptomatic measures to treat overdose.
Desloratadine overdose is not treated by hemodialysis. It is not known whether this component can be eliminated by peritoneal dialysis.

4.2. In case of missed dose of Rinofil

If you miss a dose of Rinofil, take it as soon as you remember it as soon as possible. However, you should skip the missed dose if it is too close to the time for your next dose. At that time, you should take the next dose at the right time as the treatment plan, avoid taking a double dose on your own.

5. Some side effects when using Rinofil

During the treatment of allergies with Rinofil, patients may experience some unwanted side effects. In the opinion of experts, reactions caused by Rinofil are rarely serious, but if you feel too uncomfortable or your symptoms do not go away, contact your doctor immediately.
Here are some common to rare side effects during sinofil treatment:
Common side effects (ADR > 1/100): Headache, sore throat (currently present). physical pain such as sore throat, dry throat, congestion, cough, fever, difficulty swallowing, change in voice or increased nasal secretions). Rare side effects (1/1000 < ADR < 1/100): Fatigue, dizziness, nausea, drowsiness, dry mouth, fatigue, dysmenorrhea, muscle pain (arthritis, cramps or difficulty moving), digestive disorders (heartburn, stomach acid, bloating, indigestion or upset stomach). When you notice any of the side effects warned above, you need to immediately notify your doctor or go to a medical facility for examination and timely treatment before other dangerous sequelae occur. for health.

6. Some things to keep in mind when treating with Rinofil

6.1. Contraindications and cautions when using Rinofil

Rinofil syrup should be avoided by people with a history of allergy or hypersensitivity to loratadine, desloratadine and any of the other excipients in the drug. In addition, you also need to be careful when using Rinofil if you have any of the following problems:
Do not take Rinofil before doing an allergen test (allergy skin test). Tell your doctor if your allergy symptoms do not improve after 2 days of treatment with Rinofil. Rinofil should be used with caution if there is a history of kidney or liver disease. Do not use drugs that calm the central nervous system (such as sleeping pills, tranquilizers, antidepressants) or drink alcohol during allergy treatment with Rinofil. Do not use Rinofil syrup for pregnant women or breastfeeding mothers, unless approved and closely monitored by a doctor.

6.2. Drug interactions

Rinofil may interact when combined with some other medicines. Interactions may decrease Rinofil's ability to work as well as increase the risk of side effects. Currently, scientific reports say that there is no relationship when using Rinofil with Ketoconazole or Erythromycin. In addition, the interaction of desloratadine with metabolic enzymes has not been clearly defined. Therefore, the interaction between Rinofil and some other drugs cannot be completely ruled out.
In order to ensure the safety and effectiveness during treatment with Rinofil, you need to tell your doctor all medicines and health foods that you are using, even conditions. existing disease.

6.3. How to store Rinofil

Rinofil medicine needs to be stored in a cool dry place, away from direct light and at a temperature < 30 degrees C. The drug is used within 24 months from the date of manufacture, avoid using the drug when the expiration date printed on the package has expired. envelope. In addition, you also need to store Rinofil in a place out of the reach of small children or easily accessible to pets in the house.

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