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Newbutin 300mg drug with the main active ingredient is Trimebutin and is commonly indicated in the treatment regimen of digestive dysfunction, irritable bowel syndrome or for children who often vomit, constipation, diarrhea.1. What is Newbutin?
Newbutin 300mg is available in the form of white, oblong, long-release, film-coated tablets.
Ingredients of Newbutin include:
Main active ingredients: Trimebutine maleate 300mg; Excipients such as Lactose, Calcium hydrophosphate, Microcrystalline Cellulose, Povidone, Ammonio methacrylate copolymer, Mild anhydrous silicic acid, Talc, Magnesium stearate, Opadry OY-C-7000A, Isopropanol, Methylene chloride.
2. Pharmacological characteristics of the drug Newbutin 300mg
2.1. Pharmacodynamics Trimebutin maleate in Newbutin is an active ingredient with non-competitive antispasmodic effects with serotonin antagonism and moderate affinity for opiate receptors. Therefore, Newbutin only reduces abnormal gastrointestinal motility without affecting normal motility.
Besides, studies show that Trimebutin does not cause some adverse effects such as pupil dilation or increased sweating and Newbutin is evaluated as safe during treatment, including in children and adults. elderly.
2.2. Pharmacokinetics Some studies on the metabolism of Newbutin in humans show that C14-Trimebutin maleate or the free base form of Trimebutin is rapidly absorbed after oral administration. Peak plasma concentrations of the radioactive tracer C14 of Trimebutin are reached over a period of about 1 hour.
After absorption and metabolism, Newbutin 300mg drug is excreted mainly in the urine, a small amount (about 5 to 12%) of the radioactive tracer was found in the faeces. The half-life of the active substance Trimebutin is relatively short, but the half-life of the radioactively evaluated active substance is approximately 10-12 hours.
Indications and contraindications of the drug Newbutin 300mg
Newbutin is indicated for use in the following cases:
Gastroesophageal reflux; Diaphragm hernia; Abdominal pain due to gastritis or peptic ulcer; Indigestion, nausea, vomiting; Colon dysfunction, including allergic colitis, spastic colon; Irritable bowel syndrome; Abdominal pain and bowel dysfunction not due to infection, such as diarrhea, constipation; Paralysis after surgery ; Relieves spasm of the pylorus and colon during colonoscopy. At the same time, some cases should not be used Newbutin 300mg (Contraindications):
Patients with a history of allergy or hypersensitivity to Trimebutin or any excipients contained in Newbutin Women during pregnancy Pregnant or breastfeeding should not use Newbutin Newbutin should not be used in children under 12 years of age.
Dosage and instructions for use of Newbutin
Depending on each specific subject with different levels of pathology, the doctor will have instructions to use Newbutin 300mg accordingly. The usual dose is as follows:
Adults: 3 times a day, 1 tablet of Newbutin 300mg each time; Children over 12 years old: 1-2 times a day, 1 tablet of Newbutin 300mg each time. Trimebutine overdose and treatment:
To date, there have been no symptoms or reports of Newbutin overdose; If overdose occurs after taking Newbutin, perform gastric lavage and appropriate symptomatic and supportive treatment.
5. Some notes when using Newbutin
It is necessary to store the medicine out of the reach of children; Newbutin 300mg drug needs to be stored in an airtight container, in a cool place and away from direct sunlight. When using Newbutin, patients should avoid using wet or dirty hands to dispense the medicine; Patients need to take medicine immediately after peeling, if the outer shell is torn, open, it must not be used; Newbutin 300mg drug brings fast relief of digestive disorders symptoms. However, in order to minimize the risk of unwanted side effects, patients must absolutely follow the doctor's instructions on the use of this product; Although the potential for teratogenicity of Trimebutin has not been observed in animal studies, it has not been demonstrated that it is safe to use Newbutin in pregnant women. Therefore, the use of Newbutin 300mg is not recommended for pregnant and lactating subjects.
6. Undesirable effects of Newbutin
Newbutin 300mg drug product is well tolerated and relatively safe. Therefore, only a few rare cases have recorded undesirable effects as follows:
Feeling tired, hot and cold; mild diarrhea; Nausea, vomiting; Constipation; Indigestion eating; Mild hypnosis; Dizziness due to light. Although rare, patients should promptly notify their doctor about abnormalities during treatment with Newbutin 300mg
7. Drug interactions of Newbutin 300mg
Animal studies have shown that the active ingredient trimebutin maleate can increase the lifetime of D-tubocurarine when treated with Cura drugs. In addition, no other drug interactions were noted during the clinical trial of the drug product Newbutin 300mg.
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