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Myomethol 500mg medicine contains the active ingredient methocarbamol, which is indicated in the treatment of acute osteoarthritis pain caused by skeletal muscle spasms, muscle spasms, fractures or dislocations... Let's learn about the uses and the notes. When using the drug Myomethol through the article below.
1. Uses of Myomethol
1.1. Indications "What is Myomethol?". Myomethol medicine contains the active ingredient Methocarbamol 500mg - belongs to the group of muscle relaxants, increases muscle tone. The drug is indicated in patients with acute back pain due to musculoskeletal spasm, muscle spasm, fracture or dislocation, muscle spasm due to trauma or nerve irritation, after orthopedic surgery, torticollis, inflammation microfibre. It is also effective in treating myositis, spondylitis, and nighttime leg cramps.
1.2. Pharmacodynamics Active ingredient Methocarbamol belongs to the group of muscle relaxants, mild sedative effect. The drug has a long-lasting muscle relaxant effect on skeletal muscle through selective inhibition of the central nervous system, especially on interneurons. Methocarbamol has a calming effect on the central nervous system, relieves acute pain, inhibits contractility, relieves central pain, and relieves muscle spasms.
1.3. Pharmacokinetics Absorption: The drug is rapidly and almost completely absorbed after oral administration from the gastrointestinal tract. Peak plasma concentrations of the drug are reached approximately 2 hours after a single dose. The drug takes effect about 30 minutes after taking it. Peak plasma concentrations of about 29.8 μg/ml are achieved approximately 2 hours after dosing.
Distribution: Methocarbamol is widely distributed in the body, in which the highest concentration is in the liver and kidneys, lower concentrations in the brain, lungs, spleen and lowest in skeletal muscle and heart. There are currently no studies demonstrating whether Methocarbamol is distributed into breast milk.
Metabolism and Excretion: The half-life of Methocarbamol ranges from 0.9 to 1.8 hours. The drug is extensively metabolised, mainly in the liver, via dealkylation and hydroxylation. Methocarbamol and its metabolites are rapidly and almost completely excreted in the urine. Of which, about 10 - 15% of the dose is excreted in the urine as unchanged drug, 40 - 50% of the dose is excreted as sulfate and glucuronide conjugates, the rest is excreted as unknown metabolites. .
2. Dosage of Myomethol 500mg
Myomethol 500mg is used by mouth. The recommended dose in adults is 1 to 3 tablets x 4 times/day. The recommended adult starting dose is 2 tablets, repeated every 6 hours. The dose should be adjusted depending on the patient's age, medical condition and tolerability. In case of serious disease can be treated with Myomethol for 4-6 months.
3. Undesirable effects when using Myomethol 500mg
Some side effects that may be encountered when using myomethol are as follows:
Dizziness, drowsiness, nausea, metallic taste, gastrointestinal disturbances and anorexia... However, the incidence is the above side effects are relatively low; Allergic reactions such as itching, urticaria, skin rash and conjunctivitis with nasal congestion; Urine appears dark blue; The side effects listed above are temporary and will go away when you stop taking the medicine. Patients need to inform the doctor about the unwanted effects encountered when using myomethol.
4. Notes when using Myomethol 500mg
4.1. Contraindications Contraindicated to use the drug in patients with hypersensitivity to any component of myomethol 500mg, patients with brain damage, coma, patients with myasthenia gravis and history of seizures.
4.2. Precautions for use Efficacy and safety of Methocarbamol (except for the treatment of tetanus) in children under 12 years of age have not been established. Therefore, do not use the drug in the treatment of children of this age.
For the elderly, patients with kidney failure, liver failure, it is necessary to inform the treating doctor to reduce the appropriate dose. Patients need to inform the doctor about allergic reactions to drugs, drugs being treated before using Myomethol.
Myomethol 500mg can cause headaches, dizziness, drowsiness... Alcohol increases these symptoms, so it is necessary to limit alcohol use while being treated with myomethol.
Pregnant women: The safety of this drug has not been established in pregnant women. Therefore, do not use the drug in this subject.
Lactating women: It is not known whether Methocarbamol is excreted in human milk. Therefore, caution should be exercised when using the drug in lactating women and breastfeeding should be discontinued during treatment.
5. Drug interactions
The potential for CNS depression is increased when methocarbamol is used in combination with CNS depressants, including alcohol. Therefore, care should be taken to avoid overdose.
Avoid concurrent use of Myomethol 500mg with psychotropic drugs, drugs that cause anorexia. The analgesic effect of Myomethol 500mg is enhanced when used together with other groups of analgesics.
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