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Mibedotil is a prescription medicine used in the treatment of many different conditions. So what is Mibedotil and how is it used?
1. What is Mibedotil?
Mibedotil is an antibiotic of the 3rd generation Cephalosporin group. Mibedotil is made in the form of an oral powder, the main ingredient in each package is Cefpodoxime proxetil equivalent to 100 mg of Cefpodoxime.
Cefpodoxime exerts its antibacterial action through inhibition of bacterial cell wall synthesis by means of acylation of membrane-bound transpeptidase enzymes, thereby preventing cross-linking of peptidoglycan chains required to produce a high degree of purity. strength and durability of the bacterial cell wall.
Cefpodoxime proxetil is active against Gram-positive and Gram-negative bacteria. This active substance is stable to β-lactamases. The antibacterial spectrum of Cefpodoxime includes Staphylococcus aureus with the exception of methicillin-resistant Staphylococci, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae and Streptococcus spp. other (Group C, F, G).
Gram-negative bacteria sensitive to cefpodoxime include β-lactamase-producing and non-β-lactamase-producing strains of H. influenzae, H. para-influenzae, Neisseria meningitidis, Neisseria gonorrhoeae, Moraxella catarrhalis, E. coli, Proteus vulgaris, Klebsiella pneumoniae, Providencia rettgeri and Citrobacter diversus. Cefpodoxime is also effective against Peptostreptococcus spp.
Mibedotil is indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of bacteria causing the conditions listed below:
Community-acquired pneumonia caused by H. influenzae or S. pneumoniae. Acute exacerbation of chronic bronchitis caused by S.pneumoniae, H.influenzae (including only strains that do not produce β-lactamases) or M. catarrhalis. Acute maxillary sinusitis caused by strains of Haemophilus influenzae (including β-lactamase producing strains), Streptococcus pneumoniae and Moraxella catarrhalis. Acute otitis media caused by strains of Streptococcus pneumoniae, Haemophilus influenzae (including β-lactamase-producing strains) or Moraxella (Branhamella) catarrhalis. Pharyngitis and/or tonsillitis caused by Streptococcus pyogenes bacteria. Acute, uncomplicated cervical and urethral gonorrhea caused by Neisseria gonorrhoeae (including penicillinase-producing strains). Acute, uncomplicated Neisseria gonorrhoeae (including penicillinase-producing strains) infection of the anus and rectum in women. Uncomplicated skin and skin structure infections caused by Staphylococcus aureus (including penicillinase-producing strains) or Streptococcus pyogenes. Uncomplicated urinary tract infections (cystitis) caused by bacteria Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, or Staphylococcus saprophyticus. Mibedotil is contraindicated in the following cases:
People with a history of allergy to cefpodoxime or to other cephalosporin antibiotics.
2. Dosage and how to use Mibedotil
Mibedotil is used orally, mixed with a sufficient amount of water, this medicine should be taken with food to increase absorption. The dosage of Mibedotil drug should be according to the prescription of a specialist, the recommended dose for specific cases is as follows:
Mibedotil dose for adults and adolescents (from 12 years of age and older):
Pneumonia Acute community acquired : 400mg/200mg every 12 hours for 14 days. Acute exacerbation of chronic bronchitis: 400mg/200mg every 12 hours for 10 days. Acute maxillary sinusitis: 400mg/200mg every 12 hours for 10 days. Pharyngitis and/or tonsillitis: 200mg/100mg every 12 hours for 5-10 days. Uncomplicated gonorrhea (in both men and women) and rectal gonococcal infection (women): Use a single dose of 200mg. Uncomplicated skin and skin structure infections: 800mg/400mg every 12 hours for 7-14 days. Uncomplicated urinary tract infections: 200mg/100mg every 12 hours for 7 days. In patients with severe renal impairment with creatinine clearance <30mL/min), the interval between doses of Mibedotil should be increased to 24 hours. For patients undergoing hemodialysis, the dose interval of Mibedotil is 3 times/week, taking the drug after dialysis. Mibedotil dose for children from 2 months to under 12 years old:
Acute otitis media: Use dose 10mg/kg/day (maximum 400mg/day) or dose 5mg/kg every 12 hours (maximum 200mg/dose) ) for 5 days. Pharyngitis and/or tonsillitis: 10mg/kg/day (maximum 200mg/day) or 5mg/kg/dose every 12 hours (maximum 100mg/dose) for 5-10 days. Acute maxillary sinusitis: Use 10mg/kg/day (maximum 400mg/day) or 5mg/kg every 12 hours (maximum 200mg/dose) for 10 days. There have been no reports of overdose with Cefpodoxime proxetil. Symptoms of Mibedotil overdose may include nausea, vomiting, epigastric pain, and diarrhea. In the event of a severe toxic reaction resulting from an overdose of Mibedotil, the patient will require hemodialysis or peritoneal dialysis to help remove cefpodoxime from the body, especially when renal function is impaired. decline .
3. Mibedotil side effects
The majority of side effects of Mibedotil are on the gastrointestinal tract of a mild and transient nature. Side effects of Mibedotil include:
Diarrhea, loose stools or frequent bowel movements. Stomachache. Nausea. Undigested . Bloating.
4. Interactions of Mibedotil with other drugs
Antacids: Concomitant administration of Mibedotil with high doses of antacids (sodium bicarbonate and aluminum hydroxide) resulted in a 24% decrease in peak plasma concentrations and a 27% decrease in absorption. Concomitant administration of Mibedotil with high doses of H2 blockers reduces the peak plasma concentration by 42% and the extent of absorption by 32%. Probenecid: As with other β-lactam antibiotics, renal elimination of the active substance Cefpodoxime is inhibited by probenecid. Therefore, when Mibedotil is used together with Probenecid, the AUC of Cefpodoxime increases by about 31% and its peak plasma concentration increases by 20%. Nephrotoxic drugs: Although nephrotoxicity has not been reported with Cefpodoxime proxetil alone. However, renal function should still be closely monitored when Mibedotil is used concomitantly with drugs known to be potentially nephrotoxic. The article has provided information about what Mibedotil is, dosage and precautions for use. To ensure safety for health and maximize the effectiveness of treatment, patients need to take Mibedotil exactly as directed by their doctor.
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