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Losar denk is a drug used to lower blood pressure, through the mechanism of antagonizing the angiotensin II receptor, a potent vasoconstrictor. The drug is prepared in the form of tablets with many different strengths, used for many different subjects. To learn more about Lorsar denk, read through the article below.
1. What is Losar denk 50 and 100?
Losar denk 50 and 100 are antihypertensive drugs with active ingredients: Losartan 50mg (Losar denk 50) and Losartan 100mg (Losar denk 100). Losartan is a synthetic agent of the angiotensin II AT1 receptor antagonist class. Angiotensin II is a substance produced from the renin-angiotensin system, with potent vasoconstrictor activity and a physiological determinant of hypertension. When the body makes Angiotensin II, it needs to bind to a receptor called AT1 (this receptor is present in many tissues such as vascular smooth muscle, adrenal glands, kidneys, and heart) and produce biological effects. important physiological effects, such as vasoconstriction and aldosterone release.
Losartan is a selective blocker of the AT1 receptor, because it competes for binding to this receptor in many organs, so Angiotensin II cannot bind to the receptor causing the effects of increasing blood pressure.
Losartan also does not inhibit ACE, the enzyme that breaks down bradykinin. Therefore, there is no increase in bradykinin-related undesirable effects such as dry cough.
Thanks to the mechanism of inhibiting vasoconstrictor substances and reducing the reabsorption of water and electrolytes (due to decreased production of aldosterone), the drug has a hypotensive effect. It also limits some of the side effects of ACE inhibitors.
2. Uses of the drug Losar denk 50 and 100
Losar - Denk 50 and 100 are indicated for use in:
Treatment of hypertension: The drug can be used alone or in combination with other antihypertensive drugs (eg diuretics). thiazide diuretics) to increase effectiveness in some cases. Losartan should be used in patients who cannot tolerate ACE inhibitors (angiotensin converting enzyme) because they cause side effects... Losartan is still being tested in the treatment of heart failure. This is a major advantage of angiotensin receptor antagonists, so they can also be used in the treatment of heart failure. Contraindications Losar denk 50 and 100:
Hypersensitivity to the active ingredient or any of the excipients of the drug. Women who are pregnant or breastfeeding. Patients with severe hepatic impairment because the drug is metabolized by the liver.
3. How to use Losar denk 50 and 100
How to use: The drug is prepared in the form of tablets, should be taken orally. You can take losartan on an empty stomach or on an empty stomach, but it should be maintained at the same time of day.
Dosage: The dose of this drug depends on the individual patient and must be adjusted according to the response to lowering blood pressure.
The starting dose of the drug for adults is 50 mg per day; A lower starting dose of about 25 mg/day may be used in patients who are likely to be volume-depleted, such as those on diuretics, or with hepatic impairment. The usual maintenance dose is 25-100 mg/day, which can be divided into 1-2 doses. There is no need to change the dose for elderly patients or those with renal impairment. If blood pressure cannot be controlled with the dose used, then every 1 to 2 months, the dose must be adjusted until it is effective against hypertension. If the maximum dose of losartan alone has been increased and blood pressure is not controlled, a low-dose diuretic may be added. Losartan can be used together with other antihypertensive agents. However, note that losartan should not be combined with potassium-sparing diuretics, the risk of hyperkalemia is very dangerous.
4. Losar denk 50 and 100 drug side effects
When taking the drug may cause some of the following side effects:
Common side effects include dizziness, dizziness, loss of balance, hypoglycemia, hyperkalemia. Less commonly, it causes drowsiness, headache, and sleep disturbance. Cardiovascular causes of palpitations, angina pectoris, and symptomatic hypertension are particularly common in patients with hypovolemia such as severe heart failure or being treated with high doses of diuretics. urination, excessive hypotension, orthostatic hypotension. On the skin appear rash, urticaria, itching. Abdominal pain, nausea, constipation, diarrhea, fatigue, shortness of breath, and edema may also occur. More rarely can cause syncope, atrial fibrillation, risk of cerebrovascular accident; Hypersensitivity reactions such as angioedema, dyspnea, facial swelling, lip swelling...; hepatitis When you experience mild side effects, you should inform your doctor. If serious side effects occur, seek medical attention immediately for prompt treatment.
5. Some notes when using Losar denk 50 and 100
Before taking the drug, you need to note a few things:
Before taking the drug, you need to inform your doctor about your allergy history, medical history and medications you are using. Be careful with patients with reduced intravascular volume, patients with liver failure, renal artery stenosis, hyperkalemia... When using it, it is necessary to use the correct dose prescribed by the doctor. Do not increase or decrease the dose on your own and do not forget to take the medicine. Unfortunately, you should take it again soon, but if it is close to the next dose, skip it and do not double the dose. Possible Drug Interactions: The antihypertensive effect of losartan may be enhanced by concomitant administration of other antihypertensive agents. When tricyclic antipyretics, antipsychotics, baclofen, amifostine are used together with losartan may cause excessive hypotension. In addition, may interact with other drugs such as anticoagulants, gout medications, anesthetics... Store the drug in a dry place and avoid direct light. Keep out of reach of children. Do not use when the medicine has expired, there are signs of spoilage. Hopefully, through the article you have understood what drug losar denk 100 is? and things to keep in mind when taking the drug. This medicine is only used under the prescription of a doctor, so you should not use it on your own.
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