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Lomac 20 contains the active ingredient Omeprazole 20mg, which is indicated in the prevention and treatment of peptic ulcer disease, combined with antibiotic groups in the H.pylori treatment regimen,... Let's learn about the work. Use and note when using Lomac through the article below.1. Uses of Lomac 20
"What are the effects of Lomac 20?" Lomac 20 contains the active ingredient Omeprazole, a benzimidazole derivative. Lomac is indicated in the following cases:Adults:
Peptic ulcer - duodenal ulcer; Preventing the risk of recurrent gastric and duodenal ulcers; In combination with antibiotic groups in the treatment regimens for stomach ulcers caused by Helicobacter pylori (HP); Gastric ulcers caused by non-steroidal anti-inflammatory drugs (NSAIDs); Prevention of the risk of peptic ulcer disease caused by the use of non-steroidal anti-inflammatory drugs (NSAIDs); Gastroesophageal reflux ; Preventing the risk of recurrence of reflux esophagitis in cured patients; Zollinger-Ellison syndrome. Children:
Treatment of gastroesophageal reflux disease - oesophagitis; Symptomatic treatment of acid reflux and heartburn in gastroesophageal reflux disease; Adolescents and children older than 4 years: In combination with antibiotics in the treatment of peptic ulcers caused by H.pylori bacteria.
2. Dosage of the drug Lomac 20
"Lomac 20 taken before meals or after meals, what is a reasonable dose?" Accordingly, Lomac 20 is a prescription drug and is prescribed by a doctor's prescription. Dosage depends on the age and condition of each patient. Therefore, depending on the object used, the dose of the drug will be different. Patients should note, the dosage presented below is for reference only, patients should not use it on their own, but need to follow the exact dose prescribed by the doctor. The recommended dose of Lomac 20mg is as follows:Treatment of duodenal ulcer: Take 20mg/time x 1 time/day. Most patients with duodenal ulcer recover from the disease within 2 weeks of treatment. In cases that do not heal completely during the first course of treatment, the doctor may consider extended treatment for about 2 more weeks. For patients with duodenal ulcer who respond poorly, the recommended dose is 40mg/time/day; Prevention of recurrent duodenal ulcer: The dose to prevent recurrent duodenal ulcer in H.pylori-negative patients or H.pylori-negative patients is 20mg/time/day. In some cases, just 10mg can be effective; Treatment of stomach ulcers: The recommended dose is 20mg/time/day. Most patients recover within 4 weeks of drug treatment. In case of no cure after the first course of treatment, the duration of treatment can be increased to 4 consecutive weeks. In case the patient responds poorly, the recommended dose is 40mg/time/day and usually recovers after 8 weeks of treatment; Eradicating H.pylori in patients with peptic ulcers: Combined with appropriate antibiotics for each patient, in which the dose of Omeprazol is 20mg/time x 2 times/day or 40mg/time/day; Treatment of gastric and duodenal ulcers associated with the use of NSAIDs: The recommended dose of Omeprazole is 20mg/time/day; Prevention of gastric and duodenal ulcers associated with NSAID use in high-risk patients (elderly, history of peptic ulcer, history of upper gastrointestinal bleeding: Recommended dosage: The recommended dose of Lomac 20 is 20mg/time/day; Treatment of reflux esophagitis: The recommended dose of Lomac 20 is 20mg/time/day; Long-term control in patients with cured reflux esophagitis: Dosage: Recommended dose is 10mg/time/day; Treatment of symptomatic gastroesophageal reflux disease: The recommended dose is 20mg/time/day; Treatment of Zollinger-Ellison syndrome: Dosage and duration of treatment The recommended initial dose is 60 mg once daily. All patients with severe disease and poor response to other regimens have been effectively controlled. Results when using Omeprazol and over 90% of patients using a maintenance dose of 20 - 120mg/day Lomac 20 should be taken 30 minutes before breakfast, whole tablet pill with water and do not chew or crush the tablet before taking it.
3. Side effects of Lomac 20
Lomac 20 may cause some of the following side effects:Common: Drowsiness, headache, dizziness, nausea, diarrhea, vomiting, abdominal pain, constipation, flatulence; Uncommon: Sensory disturbances, insomnia, fatigue, rash, pruritus, urticaria, transient transamin elevations; Rare: Peripheral edema, sweating, hypersensitivity including angioedema, anaphylaxis, thrombocytopenia, leukopenia, agranulocytosis, pancytopenia, autoimmune hemolytic anemia , agitation, depression, reversible confusion, hearing disorders, gynecomastia in men, Candida infection, gastritis, dry mouth, bronchospasm,...
4. Notes when using Lomac 20
4.1. Contraindications
The use of the drug is contraindicated in patients who are allergic to any of the ingredients of Lomac 20.4.2. Note when using
Before using Lomac 20 in patients with peptic ulcer disease, it is necessary to exclude the risk of malignancies, because the drug has the ability to mask symptoms and limit and delay the diagnosis of the disease.The drug may interfere with the diagnosis of neuroendocrine tumors due to the risk of increasing chromogranin-A levels. Therefore, patients should temporarily stop taking Lomac 20 at least 5 days before measuring CgA levels. .
Patients treated with omeprazole and proton pump inhibitors in general for a long time should be monitored regularly. Because the drug can increase the risk of gastrointestinal infections such as Campylobacter, Salmonella by changing the pH of the environment.
Drugs that reduce the absorption of vitamin B12 by reducing gastric acid.
Patients with renal failure and the elderly do not need to adjust the dose. For patients with liver failure, the elimination of the drug is slowed down, so it is necessary to adjust the dose accordingly.
A risk of hypomagnesemia with the use of omeprazole has been reported. Serious symptoms of hypomagnesaemia include muscle cramps, fatigue, convulsions, delirium, ventricular arrhythmias and dizziness, etc. Patients need to stop using the drug and get medical attention soon. when the above symptoms appear.
Ability to drive and operate machines: Lomac 20 does not affect the ability to drive or operate machines.
Pregnant women, lactating women: Only use the drug when absolutely necessary and need a doctor's prescription.
5. Drug interactions
Drugs with pH-dependent bioavailability: Omeprazole inhibits gastric acid secretion, so theoretically, the drug affects the bioavailability of a group of drugs whose absorption depends on gastric pH such as gastric juice. ampicillin, ketoconazole, iron salts,...Drugs metabolized by cytochrome P450 (CYP) enzymes: Omeprazole inhibits CYP2C19 enzymes, so it may interact with drugs metabolised via CYP2C19 such as clopidogrel,...
Lomac drugs increases plasma concentrations of drugs such as Diazepam, Cyclosporin, Phenytoin, Warfarin,...
Drugs that increase other effects of killing H.pylori bacteria.
Lomac increases the anticoagulant effect of Dicoumarol.
Concomitant use of Omeprazole and Clarithromycin doubles the blood concentration of Omeprazole.
Concomitant use of Omeprazole and Voriconazole (combined inhibitor of CYP3A4 and CYP2C19) may result in exposure up to twice the concentration of omeprazole.
Concomitant use of Omeprazole and Atazanavir reduces the plasma concentration of Atazanavir, thereby reducing the therapeutic effect of the drug.
Concomitant use of Omeprazol and Tacrolimus may lead to increased serum concentrations of Tacrolimus.
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