What is Lipotatin 20mg?

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1. What is Lipotatin 20mg?

Lipotatin 20mg is a lipid-lowering drug, made in the form of tablets with the main ingredient in each tablet is Atorvastatin 20mg.
Atorvastatin is a synthetic lipid-lowering drug, this active ingredient competitively and selectively inhibits the reductase HMG - CoA, it inhibits the conversion of 3 - hydroxy - 3 - methylsutaryl - coenzyme A to mevalonate, which is a prodrug. of sterols, including cholesterol.
Atorvastatin works to lower lipoprotein and cholesterol in the blood by inhibiting HMG - CoA reductase, inhibiting cholesterol synthesis in the liver and increasing the number of LDL receptors on the cell surface in the liver to increase the uptake of cholesterol. go and degrade LDL.
Atorvastatin is effective in reducing the production of LDL and LDL particles in patients with homozygous familial hypercholesterolemia.

2. Indications and contraindications

2.1. Indications Lipotatin 20mg is indicated in the following cases:
Increased total cholesterol, increased LDL - cholesterol, increased apolipoprotein B, mixed dyslipidemia, hypertriglyceridemia, beta - lipoprotein blood disorder Increases HDL - cholesterol in patients with primary hypercholesterolemia. Homozygous familial hypercholesterolemia. 2.2. Contraindications Lipotatin 20mg is contraindicated in the following cases:
People who are sensitive to any of the ingredients of the drug. Active liver disease or unexplained persistent elevations of serum transaminases in excess of 3 times the upper limit of normal. Women who are pregnant and breast-feeding or suspected of being pregnant. Avoid using Lipotatin 20mg while taking tipranavir + ritonavir, telaprevir.

3. Dosage and how to use Lipotatin 20mg

Lipotatin 20mg is taken orally. The drug can be taken at any time of the day, regardless of meals.
Dosage of Lipotatin 20mg should be according to the doctor's prescription. The reference dose is as follows:
Hypercholesterolemia and mixed dyslipidemia use the starting dose of 10 - 20mg, once a day. Patients requiring significant LDL-cholesterol reduction (more than 45%) can be started on Lipotatin 20 mg at a dose of 40 mg once daily. The therapeutic dose range of Lipotatin 20mg is 10 - 80 mg once daily. After starting treatment and/or after increasing the dose of Lipotatin 20mg, it is necessary to assess blood lipids within 2-4 weeks and to adjust the dose accordingly. Homozygous familial hypercholesterolemia is used at a dose of 10 to 80 mg/day and should be combined with other lipid-lowering measures. Lipotatin 20mg can be combined with resin to increase the effectiveness of treatment. When co-administering Lipotatin 20mg with drugs darunavir + ritonavir, fosamprenavir, fosamprenavir + ritonavir, saquinavir + ritonavir, the dose of Lipotatin 20 mg should not exceed 20 mg/day. When co-administered with nelfinavir, the dose of Lipotatin 20mg should not exceed 40mg/day. Concomitant use of Lipotatin 20mg with cyclosporin, use a maximum dose of 10mg/day. When co-administering Lipotatin 20mg with clarithromycin, the starting dose is 10mg/day, maximum 20mg/day. When co-administering Lipotatin 20mg with itraconazole, the starting dose is 10mg/day, maximum 40mg/day. If you forget a dose of Lipotatin 20mg, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Do not take a double dose.

4. Side effects of Lipotatin 20mg

When using Lipotatin 20mg, you may experience unwanted effects, including:
Constipation Flatulence Indigestion Abdominal pain Headache Nausea Muscle pain Fatigue Diarrhea Insomnia. Angioedema Muscle cramps Myositis Paresthesia Peripheral neuropathy Hepatitis, anorexia, vomiting. Cognitive impairment (memory loss, confusion,...) Increased blood sugar, increased HbA1c. When experiencing side effects of Lipotatin 20mg, you need to stop using it and notify your doctor or go to the nearest medical facility for timely treatment.

5. Drug interaction Lipotatin 20mg with other drugs

When Lipotatin 20mg is used concurrently with Cyclosporin, fibric acid derivatives, erythromycin, azole antifungals or niacin, there will be an increased possibility of myopathy. When Lipotatin 20mg is used together with Antacid, the plasma concentration of atorvastatin will be reduced by about 35%. When Lipotatin 20mg is used with Cholestyramine, the plasma concentration of atorvastatin is reduced by about 25%, but the effect of lipid treatment is higher. When using Lipotatin 20mg with Digoxin, the plasma concentration of digoxin will increase by nearly 20%. Co-administration of Lipotatin 20 mg with Erythromycin increased plasma concentrations of atorvastatin (40%). Co-administration of Lipotatin 20mg with oral contraceptives containing norethindrone and ethinyl estradiol increased the AUC of norethindrone and ethinyl estradiol by almost 20%. Co-administration of Lipotatin 20mg with inhibitors of the CYP3A4 enzyme may increase plasma concentrations of the drug, leading to an increased risk of myopathy and myopathy. When co-administering Lipotatin 20 mg with amiodarone, the dose should not exceed 20 mg/day. Increased risk of muscle damage when Lipotatin 20mg is used concurrently with the following drugs: Gemfibrozil, high-dose niacin (> 1g/day), other fibrate-lowering agents, colchicine. Concomitant use of Lipotatin 20mg with drugs to treat HIV and hepatitis C may increase the risk of muscle damage, most serious complications of rhabdomyolysis, kidney failure, leading to kidney failure and possibly kidney failure. deadly. Avoid using Lipotatin 20mg with tipsranavir + ritonavir, telaprevir.

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