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Lipotatin 10mg is a drug that is trusted by many doctors and medical professionals in the industry. Lipotatin 10mg can be taken at any time of the day, regardless of meals. So what is Lipotatin 10mg?
1. What is Lipotatin 10mg?
Lipotatin 10mg is a drug manufactured by Mebiphar Pharmaceutical and Biomedical Joint Stock Company. The main ingredient of Lipotatin 10mg is Atorvastatin 20mg, which is prepared in the form of film-coated tablets. Atorvastatin is a synthetic lipid-lowering drug with competitive and selective inhibition of HMG-CoA reductase. Thereby inhibiting the conversion of 3-hydroxy-3-methylsutaryl-coenzyme A to mevalonate - a precursor of sterols including cholesterol, reducing lipoproteins and plasma cholesterol. The drug also inhibits the synthesis of cholesterol in the liver, increases the number of hepatic LDL receptors on the cell surface, increases the removal and degradation of LDL. Atorvastatin reduces LDL production in patients with homozygous familial hypercholesterolemia, significantly increasing LDL receptor activity.
2. Uses of Lipotatin 10mg
Lipotatin 10mg is used in the following cases:
As an adjunct to diet in the treatment of elevated total cholesterol, elevated LDL-cholesterol, increased apolipoprotein B, increased triglycerides, mixed dyslipidemia (group Ila and Ilb - Fredrickson's classification), beta-lipoproteinemia disorder. Lipotatin 10mg also helps increase HDL - cholesterol in patients with primary hypercholesterolemia. Lipotatin 10mg is indicated when diet and non-pharmacological methods have not been effective, active ingredient Atorvastatin is also used to reduce blood cholesterol homozygous familial.
3. Dosage of Lipotatin 10mg
Lipotatin 10mg drug is taken orally according to the doctor's prescription. Before treatment and during treatment with Lipotatin 10mg, patients need to follow a reasonable diet. Dosage of Lipotatin 10mg:
Hypercholesterolemia (heterozygous familial/non-familial), mixed dyslipidemia (group lla and Ilb according to Fredrickson classification) Lipotatin 10mg starting dose is 1 –2 tablets x 1 time/day, the therapeutic dose is 1–8 tablets x 1 time/day. Dosage of Lipotatin 10mg requires specific adjustment based on the characteristics of each patient. For patients who need to reduce LDL cholesterol significantly (over 45%) can take Lipotatin 10mg at a dose of 4 tablets / time / day. Homozygous familial hypercholesterolemia: Lipotatin 10 mg at a dose of 1–8 tablets/day and in combination with other lipid-lowering measures. Notes on the dose of Lipotatin 10mg:
Combination therapy: Lipotatin 10mg can be combined with resin to increase the effectiveness of treatment. Treatment of HMG-CoA reductase inhibitors such as Lipotatin 10mg should not be combined with fibrates. When using Lipotatin 10mg in combination with amiodarone, no more than 2 Lipotatin 10mg tablets should be used in a day. Lipotatin 10mg should be started with the lowest effective dose, and then the dose of Lipotatin 10mg can be adjusted according to individual needs and response by increasing the dose in phases, spaced not less than 4 weeks apart. , monitor adverse drug reactions, especially on the muscle system. The lowest dose of atorvastatin should be used when Lipotatin 10mg is co-administered with Lopinavir + Ritonavir. When using Lipotatin 10mg with drugs Darunavir + Ritonavir, Fosamprenavir, Fosamprenavir + Ritonavir, saquinavir + Ritonavir, the dose of active ingredient Atorvastatin does not exceed 20 mg/day. When using Lipotatin 10mg with Nelfinavir: Do not exceed 40 mg of active ingredient Atorvastatin/day. Co-administration of Lipotatin 10mg with cyclosporin, maximum 10mg Atorvastatin/day; Co-administration of Lipotatin 10mg with Clarithromycin, starting at 10mg Atorvastatin/day, maximum 20mg Atorvastatin/day; Co-administration of Lipotatin 10mg with Itraconazole, starting at 10mg Atorvastatin/day, maximum 40mg Atorvastatin/day. Note: The above dose of Atorvastatin is for reference only, the specific dose of Lipotatin 10mg depends on the condition and progression of the disease, it is necessary to consult a doctor for the most accurate Lipotatin 10mg dose.
4. Side effects of Lipotatin 10mg
When using Lipotatin 10mg, there may be unwanted effects: In clinical trials, less than 2% of patients had to stop taking Lipotatin 10mg because of side effects, about 1% of patients experienced side effects. Adverse effects: Constipation, flatulence, indigestion, abdominal pain, headache, nausea, muscle pain, fatigue, diarrhea, insomnia... Side effects of Lipotatin 10mg have been reported: Mental edema meridians, cramps, myositis, peripheral neuropathy, hepatitis, anorexia, vomiting, cognitive impairment (dementia, confusion,...)
5. Contraindications of Lipotatin 10mg
Lipotatin 10mg is contraindicated for use in the following patients:
Hypersensitivity to the active ingredient Atorvastatin or to any component of Lipotatin 10mg; Active liver disease or unexplained persistent elevations in serum transaminases greater than 3 times the upper limit of normal; Women who are pregnant, nursing or suspect that they are pregnant should not take Lipotatin 10mg
6. Be careful when using Lipotatin 10mg
Consideration should be given when administering Lipotatin 10mg or statin drugs to patients with risk factors for muscle damage. Statin drugs such as Lipotatin 10mg have a risk of causing adverse reactions to the muscle system: muscle atrophy, myositis, especially common in patients with risk factors such as: over 65 years old, disease uncontrolled hypothyroidism, kidney disease... need to closely monitor for adverse reactions during the use of Lipotatin 10mg. Effects on the liver: Lipotatin 10mg may cause increases in creatinine phosphokinase and transaminases, which should be reduced or discontinued when ALT or AST increases more than 3 times above normal. Lipotatin 10mg should be used with caution in patients who drink alcohol and have a history of liver disease; Before treatment, CK testing should be performed in the following cases: Impaired renal function, hypothyroidism, hereditary disease, history of myopathy due to statin or fibrate use, elderly patients (> 70 years of age) ) have risk factors for rhabdomyolysis... if the CK test results are > 5 times the upper limit of normal, treatment with Lipotatin 10mg should not be started. During treatment with Lipotatin 10mg, there will be muscle pain, stiffness or factor, with an increase in creatine phosphokinase (CPK) > 10 times the upper limit, then notify your doctor immediately, stop treatment. Lipotatin 10mg if CPK is markedly elevated or myopathy is suspected. Patients with severe and acute disease, at risk for myositis or predisposing factors for the development of secondary renal failure, should temporarily reduce the dose or discontinue treatment with Lipotatin 10mg. Do not use Lipotatin 10mg for pregnant women, women who are taking the drug should not breast-feed.
7. Drug interactions of Lipotatin 10mg
Cyclosporin, fibric acid derivatives, erythromycin, azole antifungals, niacin may increase the possibility of myopathy when used concomitantly with Lipotatin 10mg; Plasma concentrations of atorvastatin are reduced by approximately 35% when administered with an oral antacid containing magnesium and aluminum hydroxide; Cholestyramine: Plasma concentrations of atorvastatin are reduced by about 25%, but the effect of lipid-lowering therapy is higher when Lipotatin 10mg is used concurrently with cholestyramine; Digoxin: Digoxin plasma concentration will increase by nearly 20% when used with Lipotatin 10mg; Erythromycin: increases plasma concentrations of atorvastatin; Oral contraceptives: Concomitant use of Lipotatin 10mg with oral contraceptives containing norethindrone and ethinyl estradiol will increase the AUC of oral contraceptives by nearly 20%; Co-administration of CYP3A4 enzyme inhibitors may increase plasma concentrations of Lipotatin 10 mg leading to an increased risk of myopathy and myopathy; Increased risk of muscle damage when using Lipotatin 10mg concurrently with drugs: Gemfibrozil, fibrate-lowering cholesterol, high-dose niacin, colchicine; The use of Lipotatin 10mg concurrently with drugs for HIV and hepatitis C virus (HCV) will increase the risk of muscle damage, rhabdomyolysis, kidney failure, even kidney failure and possibly death; Avoid taking Lipotatin 10mg with Tipranavir + Ritonavir, Telaprevir.
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