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Goldesome 20mg drug with Esomeprazole ingredient is made in the form of film-coated tablets. The drug is indicated to prevent the secretion of gastric juice, improve the condition of gastric and duodenal ulcers. However, when using Goldesome 20mg, there may be some unwanted side effects such as headache, dizziness, diarrhea,... Therefore, you need to learn carefully about the drug and be prescribed to use it. by the treating physician.
1. Mechanism of action of the drug Goldesome 20mg
Goldesome medicine 20mg contains the main ingredient is Esomeprazole. This compound is the S-isomer of omeprazole used in a similar way to the copolymer in the treatment of peptic ulcer disease, or the treatment of gastroesophageal reflux disease. Esomeprazole, when bound to the proton pump H+/K+-ATPase in the cells of the gastric wall, helps to specifically inhibit the enzyme system here, preventing acid secretion into the gastric lumen. Therefore, the compound esomeprazole has the effect of inhibiting basic acid secretion even when stimulated by other agents.
When Esomeprazole enters the body, it is rapidly absorbed and reaches peak plasma concentrations after 1-2 hours. The bioavailability of this compound also increased with dose and repeated administration, corresponding to 68% for the 20 mg dose and 89% for the 40 mg dose, respectively. However, food can affect and delay the absorption of Esomeprazole, the area of the curve after a single dose of 40 mg with a meal compared with fasting is reduced from 33% to 53%. Therefore, Esomeprazole must be taken at least 1 hour before eating. In addition, when Esomeprazole is absorbed into the body, it is about 97% bound to plasma proteins and has a relatively stable volume of distribution of concentrations of 16 liters in healthy subjects.
Goldesome 20mg drug is metabolized mainly in the liver by isoenzyme CYP2C19, cytochrome P450 enzyme system. The product will be converted to hydroxy and desmethyl is inactive. The remainder is metabolized by the CYP3A4 isoenzyme to omeprazole sulfone. When Goldesome 20mg is used as a booster, the initial metabolism will be through the liver and the clearance of the drug is reduced. However, there is no phenomenon that the drug accumulates every day of use. The reason for the slow metabolism is that in some people there is an inherited deficiency of the isoenzyme CYP2C19 and leads to an increase in AUC that is more than 2 times higher than in the general population. Goldesome 20mg has a plasma elimination half-life of 1 to 1.5 hours, with 80% of the administered dose being eliminated as inactive metabolites in the urine and the remainder in the feces. In patients with severe hepatic impairment, steady-state AUC values are usually 2 to 3 times higher than those with normal liver function. Therefore, reduce the dose of Goldesome 20mg in these patients to no more than 20mg per day.
2. Indications and contraindications for using Goldesome 20mg
What is Goldesome drug? Goldesome drugs include: Goldesome 20mg and Goldesome 40mg are indicated for use in the treatment of benign peptic ulcer disease or people with Zollinger-Ellison syndrome, or people with gastroesophageal reflux disease- Severe esophagitis with signs such as erosive, ulcerative or strict esophagitis...
Moreover, Goldesome 20mg drug can be used in the prevention and treatment of peptic ulcer due to the use of non-steroidal anti-inflammatory drugs. steroids .
Goldesome 20mg drug is also contraindicated in some cases such as:
People with a history of allergy or hypersensitivity to the components of the drug causing proton pump inhibitors. Those who cannot use the combination with the components esomeprazole and nelfinavir.
3. Dosage and how to use Goldesome 20mg
Goldesome 20mg drug is prepared in tablet form and used orally. Patients should take the drug at least 1 hour before meals. When taking the drug, swallow the tablet whole with water. Do not chew or crush the medicine before taking it. Because the duration of taking proton inhibitors must be based on the level of safety and effectiveness of treatment.
Dosage for each case:
Treatment of peptic ulcer disease including Helicobacter pylori: In the treatment regimen of this disease, Esomeprazole is prescribed to use the same antibiotic with a dosage of 20mg per day. times equivalent to one Goldesome 20mg tablet, twice daily and taken for 7 days. Treatment of inflammatory gastroesophageal reflux disease using 40mg Goldesome equivalent to 2 Goldesome 20mg tablets, taken for about 4 to 8 weeks. If there are still symptoms of disease or inflammation through endoscopy, it can be taken for another 4 to 8 weeks. Maintenance treatment for patients who have recovered from esophagitis: use a dose of 20mg per day equivalent to 1 Goldesome 20mg tablet. And can extend the time of taking the drug up to 6 months. Treatment of symptomatic gastroesophageal reflux disease without esophagitis: a daily dose of 20mg equivalent to one 20mg Goldesome tablet and used for about 4 weeks. If the condition is not completely cured, it can be continued for another 4 weeks. Treatment of gastric ulcers caused by the use of non-steroidal anti-inflammatory drugs: use the drug every day with a single dose of 20mg equivalent to one 20mg Goldesome tablet and use it for 4 to 8 weeks. Prophylaxis of peptic ulcer disease caused by the use of steroid anti-inflammatory drugs in patients at risk: a once-daily dose of 20 mg Goldesome. Treatment of Zollinger-Ellison syndrome: With each specific case along with the degree of increased gastric acid secretion, the dose of Goldesome may be different. Usually used once or divided into two times a day. However, when symptoms are controlled, surgery can be used to completely remove the tumor. The dosage of Goldesome 20mg above is for reference only. Therefore, if you use the drug to improve your health, you need to learn carefully and consult a doctor.
If you forget to take your medicine, use it as soon as you remember. However, if the missed dose of Goldesome 20mg is close to your next dose, skip the missed dose and take the next dose. You should note that you should not double the dose of Goldesome 20mg, because this can cause bad symptoms affecting health.
In case of drug overdose, the drug will not help improve the symptoms of the disease immediately. Instead, it can cause poisoning or other serious side effects. If you suspect you have overdosed, call your doctor or go to a medical facility right away.
4. Unexpected side effects when using the drug Goldesome 20mg
Goldesome 20mg drug can cause unwanted side effects during treatment. Common side effects include systemic symptoms such as headache, dizziness, skin rash or nausea, abdominal pain, constipation, flatulence, dry mouth. In addition, in some cases, there may be rare side effects such as insomnia, itching, visual disturbances, peripheral edema, sensitivity to light, agitation, depression ...
If when using If you experience any unusual symptoms, you should stop using the medicine and see your doctor to find out the specific cause. Some notes when using Goldesome 20mg drug include:
Goldesome 20mg drug has the ability to inhibit the proton pump, so if using the drug, it may mask the symptoms and slow down the detection of cancer signs. In people with liver disease, or who are pregnant or breastfeeding, caution should be exercised when using Goldesome 20mg. Because it can cause atrophic gastritis. Drug interactions: Because the drug Goldesome 20mg inhibits acid secretion and esomeprazole increases gastric pH, it may affect the bioavailability of the drug when the drug is dependent on Ketoconazole, iron salts or digoxin,... Or Goldesome drug 20mg may interact pharmacokinetics with drugs that metabolize cytochrome P450 enzymes. Goldesome 20mg drug contains Esomeprazole, which is made in the form of film-coated tablets. The drug is indicated to prevent the secretion of gastric juice, improve the condition of gastric and duodenal ulcers. To ensure effective treatment and avoid side effects, patients need to use prescription drugs or consult a doctor.
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