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Gensonmax medicine is made in the form of a topical cream, the package includes a box of 1 tube of 10g. The drug is indicated for the treatment of dermatological diseases with good results. To ensure effective use and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor.
1. What is Gensonmax? The effect of the drug Gensonmax
1.1. What is Gensonmax topical? Gensonmax topical is a topical medication used to treat symptoms of dermatological diseases such as contact dermatitis, insect stings or dermatitis caused by secondary bacterial infections.
Ingredients for a tube of Gensonmax 10g topical include:
Clotrimazol: 0.1 g; Gentamicin (as Gentamicin sulfate): 0.01 grams; Betamethasone dipropionate: 0.0064 grams; Other excipients in sufficient quantities. The dosage form of the drug Gensonmax is: Skin cream.
1.2. The effect of Gensonmax topical cream Gensonmax topical cream is a combination of 3 active ingredients with synergistic effects. Clotrimazol is a fungicide, Gentamicin is an antibiotic belonging to the group with bactericidal effects and Betamethasone dipropionate is a synthetic corticosteroid with anti-inflammatory and anti-allergic effects. Specific effects for each active ingredient are as follows:
Clotrimazol is a broad-spectrum antifungal drug of the azole group, due to its low absorption capacity, it mainly treats fungal infections of the skin, mucous membranes and vaginal candidiasis. All azole antifungals are capable of inhibiting the alpha demethylase enzyme, which prevents the synthesis of ergosterol and lipids of the fungal cell membrane, changes the permeability of the cell membrane, thereby destroying fungal cells. Gentamicin is an aminoglycoside antibiotic that is active mainly on gram-negative aerobic bacteria and some specific gram-positive bacteria such as staphylococcus, streptococcus, pneumococcus. Drugs for the treatment of serious infections caused by gram-negative bacteria acquired in the hospital such as bacteremia, biliary tract infections, pneumonia, urinary tract infections. Besides, Gentamicin antibiotic is also effective against some bacteria such as Mycoplasma, Actinomyes. Mycobacterium, fungi and anaerobic bacteria with anti-Gentamicin activity. Betamethasone is a corticosteroid with strong glucocorticoid effects, and also has anti-inflammatory, anti-allergic, vasoconstrictor, rheumatic, lupus, multiple sclerosis, problems caused by low levels of adrenal hormones. Betamethasone can suppress the inflammatory response but cannot cure it completely. When you stop using the drug can cause the disease to come back. Corticosteroids have the ability to suppress the immune system, which can lead to increased rates of infection and reduced effectiveness of vaccines and antibiotics. Long-term use of Betamethasone can cause osteoporosis leading to fractures, adrenal gland shrinkage or atrophy leading to some unwanted side effects to health such as nausea or vomiting. 1.3. The pharmacokinetics of Gensonmax topical Clotrimazole is relatively low when applied topically. After topical application, the drug is distributed into the stratum corneum, the lower layer of the skin. Clotrimazoles are absorbed after metabolism, excreted mainly in the bile, excreted in the feces and urine. The mean half-life is between 3.5 and 5 hours. Gentamicin antibiotics like other aminosides, gentamicin is less absorbed from the gastrointestinal tract but well absorbed through intravenous and intramuscular injection. The drug can reach its maximum concentration 30 to 60 minutes after intramuscular injection. Gentamicin is absorbed mainly in the extracellular fluid and has relatively little metabolism in vivo. In addition, the active substance Gentamicin is eliminated mainly via the urinary tract, with an average half-life of 2 to 4 hours. Betamethasone is readily absorbed when applied directly to the skin, and is less widely bound to plasma proteins. The drug is metabolized mainly by the liver, partly in the kidneys and excreted from the body in the urine.
2. Indications of the drug Gensonmax
Gensonmax topical is used topically to treat the following pathological symptoms:
Atopic dermatitis, atopic eczema, also known as eczema, seborrheic dermatitis, ichthyosis, contact dermatitis , anal itching, vaginal itching, ... Some dermatophytosis skin diseases such as ringworm, ringworm, stem fungus, nail fungus, trichophyton fungus,... Suspected infection caused by bacteria secondary. Prevents infection from insect stings or minor burns on the skin.
3. Usage and dosage of the drug Gensonmax
3.1. Dosage of Gensonmax You can apply a layer of Gensonmax cream just enough on the affected skin area in each time, 2-3 times a day. For the best effect of the medicine, you should apply it regularly.
3.2. How to use Gensonmax Before applying Gensonmax you need to wash your hands and the area to be applied. Take an appropriate amount of cream and rub it evenly on the damaged skin and surrounding areas, making sure to cover the areas evenly. Do not apply too strong medicine that can negatively affect the skin, facilitate dermatitis, bacterial infection to progress worse. Wash your hands after using Gensonmax topical, unless you are treating a skin infection. Keep the affected area clean and check it regularly. The duration of the treatment depends on the patient's medical condition, the damaged skin, and the extent of the damage. If after about 4 weeks of use, you don't see any effect, you need to review and maybe change to another drug when prescribed by the treating doctor.
3.3. In case of overdose/forgotten dose In case of overdose: The composition of Gensonmax topical contains corticosteroids, so when using the drug in overdose, symptoms of corticosteroid overdose include: increased appetite, calcium mobilization. and phosphorus associated with osteoporosis, nitrogen loss, tissue-reducing effect, hyperglycemia, increased susceptibility to infection, adrenal insufficiency, increased adrenal cortex activity, mental and neurological disorders, muscle weakness. In case of acute overdose, the doctor will prescribe monitoring of serum and urine electrolytes, paying special attention to the balance of sodium and potassium. In case of chronic toxicity, stop using the drug slowly, treat electrolyte imbalance if necessary. Because the cause of drug overdose has no specific antidote, gentamicin overdose or toxic reactions are symptomatic and supportive. If you forget to take a dose, take it again as soon as you remember. If you remember when it's almost time for your next dose, skip it and stick to your usual dosing schedule. You should not apply twice the amount of medicine.
4. Undesirable effects of the drug Gensonmax
Some unusual manifestations may occur such as itching, redness, burning, irritation, erythema, urticaria, peeling, blistering, generalized allergy or anaphylactic reaction,. .. It is necessary to pay attention to the dose used because if the drug is used in large doses for a long time, it can cause unwanted side effects similar to when using systemic corticosteroids. If the drug is used on a large scale, there is a pressure bandage that can cause skin irritation, dermatitis, hypopigmentation, rash, acne, ... The above are just some unwanted effects when using the drug, so the Side effects may be incomplete. You need to pay attention when using, if there are any other abnormal health symptoms, please consult the treating doctor.
5. Gensonmax drug interactions
Topical drugs containing ingredients: Calcium, sulfafurazol, heparin, sulfacetamide, magnesium, acetylcysteine, chloramphenicol, actinomycin, doxorubicin, clindamycin reduce the effect of Gensonmax topical (caused by decreased activity of gentamicin). .
Use of Gensonmax topical with neuroleptics may cause muscle relaxation. In addition, the drug should not be used with some nephrotoxic drugs, because it may increase nephrotoxicity. Co-administration of an aminoglycoside such as Gentamicin with a beta lactam may increase bactericidal activity, and is usually indicated in patients with severe disease or impaired resistance.
Contraindicated to use drugs containing gentamicin in people with kidney damage, hearing or allergy to the drug. Gentamicin antibiotics for people with meningitis will not work because the bacteria are in a "resting" state. Betamethasone is a corticosteroid, which works to soothe inflamed areas of the body, reducing swelling, redness, itching, and allergic reactions. It is not recommended to use this medicine while being treated with some drugs such as Desmopressin, Rilpivirine, Aceclofenac, Fluvoxamine, Ofloxacin, Piroxicam, Hydrocodone, Ibuprofen, Phenobarbital, Phenylbutazone ... or some vaccines such as Adenovirus vaccine, chickenpox vaccine, Varicella virus vaccine, ...
If you use Gensonmax topical for a long time, you may need to monitor your diet, calories or add more protein to your diet, diet potassium-rich diet. Besides, the treating doctor may ask you to have an ophthalmology examination in necessary cases.
In addition, the active ingredient Gensonmax can also interact with foods, alcohol, and tobacco.
6. Some notes when using Gensonmax drug
Before using Gensonmax topical, you need to carefully consult the instructions of the treating doctor, carefully read the instructions for use and refer to the information below.
6.1. Contraindications of Gensonmax topical Gensonmax topical is contraindicated in the following cases:
Not used for people who are sensitive to one of the ingredients of the drug. Do not apply the medicine on broken skin, extensive damage or closed wounds, especially in children and infants. Do not use the drug in the following cases: Tuberculosis, herpes simplex, shingles, eczema due to them chickenpox, syphilis. Do not use in ophthalmology. 6.2. Precautions when using Gensonmax topical The lowest possible dose of corticosteroids should be used to control the disease under treatment when the dose is reduced, tapering gradually. Do not use in the treatment of systemic fungi. Inform the treating physician if irritation occurs in the application area. Prolonged use of topical antibiotics can facilitate the rapid growth of non-susceptible pathogens such as fungi. Since Gensonmax topical contains Gentamicin, caution should be exercised regarding the risk of cross-allergenicity between aminoglycoside antibiotics. For children:
Children may have more obvious manifestations of adrenal insufficiency, which is caused by the use of corticosteroids, than adults. This is due to the greater ratio of the damaged skin surface to the weight of the whole body. Children may experience signs of Cushing's syndrome, growth retardation, weight gain and increased intracranial pressure have been reported in children receiving topical corticosteroids. Manifestations of adrenal insufficiency in children include low plasma cortisol levels and unresponsiveness to ACTH stimulation. Clinical manifestations of raised intracranial pressure include fontanelle bulge, headache, and bilateral papilledema. Other notes:
For the ability to drive and use machines: The drug is suitable for driving and operating machines. Pregnancy: When using corticosteroids during pregnancy or in a person of childbearing potential, it is necessary to follow the instructions of the treating physician after weighing the benefits and risks of the drug to the mother and embryo or fetus. Lactation: Gensonmax topical is excreted in breast milk and may be harmful to infants, as it may inhibit growth and cause other adverse effects such as hypoadrenalism. The benefit to the mother must be weighed against the potential harm to the infant. Gensonmax medicine is prepared in the form of a cream for topical application, packaging includes a box of 1 tube of 10g. The drug is indicated for the treatment of dermatological diseases with good results. To ensure effective use and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor.
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