This is an automatically translated article.
Acytomax is a medication used externally to treat certain dermatological conditions. Acytomax is a product of Ha Tay Pharmaceutical Joint Stock Company (Vietnam). To ensure effective use, users need to strictly follow the instructions of a doctor, professional pharmacist.
1. What is Acytomax?
What is Acytomax? Acytomax is an over-the-counter medication used to treat skin conditions. Acytomax medicine contains the main ingredient is Aciclovir 250 mg/5g and excipients are sufficient including Propylene glycol, Cetosteryl alcohol, Cremophor A6, Cremophor A25, Butyl hydroxytoluene, Sodium metabisulfite, Paraffin oil, Purified water.
Acytomax medicine is prepared in the form of a cream, packaged in a tube.
Mechanism of action of active ingredients Acyclovir:
Pharmacodynamic properties of Acyclovir: Acyclovir is an active nucleoside analogue (acycloguanosin), which has a selective effect on cells infected with the Herpes virus. Acyclovir must be phosphorylated to the active form acyclovir triphosphate to be effective. Acyclovir is first metabolized to acyclovir monophosphate by the viral enzyme thymidinekinase, and then further converted to acyclovir diphosphate and triphosphate by several other cellular enzymes. Acyclovir triphosphate inhibits the herpes simplex virus DNA polymerase, thereby preventing viral DNA synthesis and viral reproduction without affecting normal cellular metabolism.
Pharmacokinetic properties of Acyclovir:
Aciclovir penetrates the skin. Skin concentrations are higher than the minimum inhibitory concentration (MIC) in soft tissue at steady state.
After applying acyclovir to the skin, no acyclovir appeared in the plasma. Data are available for oral and intravenous use only.
In vitro and in vivo of aciclovir cream and aciclovir ointment versus oral aciclovir were performed to determine the bioavailability of aciclovir in human skin. In vitro studies used human skin, while biopsies either used surgical human skin grafts in mice or were validated. Drug concentrations appear for both topical and oral forms of aciclovir: in the skin structure the dermis is larger than the epidermis, the epidermis is larger than the dermis. There was no difference in concentration between the cream and the ointment.
The upper layers of the epidermis showed on average 48 times higher concentrations after application of aciclovir ointment or 5% cream than after oral administration, but drug concentrations in the basal epidermis - the site of viral infection Herpes - in topical form is 2-3 times lower than an oral dose. On the basis of continuous absorption concentrations increased over time (higher drug concentrations were found 48 hours later than 24 hours after application). Therefore, a short dosing period is reasonable for the treatment of Herpes simplex virus infections.
2. What are the uses of Acytomax?
Acytomax is used to treat herpes simplex skin virus infections (including lip herpes and genital herpes) both initial and recurrent.
Patients need to adhere to the correct use of the drug according to the specified subjects indicated on the Acytomax drug instruction sheet or the doctor's instructions.
3. How to use and dosage of Acytomax?
Treatment with Acytomax must be started as soon as possible at the onset of signs and symptoms of the disease.
Apply a sufficient amount of Acytomax cream to the area of the skin with signs of infection (vesicles, swelling, redness...) and also in the surrounding areas with a cotton swab. If applying the cream by hand, wash your hands thoroughly before and after application to avoid superinfection of the damaged skin, and at the same time avoid spreading the virus to uninfected skin and mucous membranes.
Use every 4 hours (about 5-6 times a day for 5-7 days. In some cases where the above course of treatment is still not cured, it is recommended to prolong the treatment until healed. Note, the duration of continuous treatment should not exceed 10 days.
It is necessary to apply the exact dose of Acytomax indicated on the package, the drug instruction sheet or the instructions of the doctor or pharmacist. Use compared to instructions for use or prescribed by your doctor.
4. In case of an overdose of Acytomax, what should we do?
Read the package insert carefully and follow the exact dose indicated on it. In case of an overdose of Acytomax, you should stop using it and notify your doctor or pharmacist immediately if you have any unusual symptoms.
If you forget to take your dose of Acytomax on time, apply it as soon as you remember.
5. In which cases should Acytomax not be used?
Acytomax medicine should not be used in the following cases:
Cases of hypersensitivity to aciclovir or any of the ingredients in the drug. Do not use Acytomax cream near the eyes, in the mouth, or in the vagina.
6. What are the unwanted side effects when taking Acytomax?
Users of the drug may experience a temporary burning or stinging sensation at the application site, accompanied by a slight erythema when the drug dries. These symptoms usually go away when the drug is stopped.
Usually these side effects or unwanted effects go away when the medication is stopped. However, if there are other rare side effects that are not listed in this leaflet, tell your doctor or pharmacist right away.
7. What should be noted and cautioned when using Acytomax?
Avoid applying the medicine to the mucous membranes of the mouth or eyes. Pregnant and lactating women can use Acytomax but need to consult a doctor before taking. Acytomax should be used with caution in patients with renal impairment. There are no drug interactions when used in topical cream form due to very low absorption into the blood.
8. How to store Acytomax?
It is necessary to store medicines properly to ensure the quality of medicines. Besides, before using, users also need to pay attention to the expiry date of the drug. According to the manufacturer's recommendations, the shelf life of the drug is 24 months from the time of packaging. The user should only use the expired medicine. If, when opening the tube, you see a layer of separation, no sticking to the skin, or any abnormality, you should not use it and return it to the place of sale or the manufacturer for handling.
Acytomax is a medication used externally to treat certain dermatological conditions. To ensure effective use, users need to strictly follow the instructions of a doctor, professional pharmacist.
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