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Encorate drug with concentrations of 200, 300, 500mg of the active ingredient Sodium valproate, has the effect of inhibiting the activity of the neurotransmitter GABA. So what disease does Encorate treat?
1. What is the use of encorate?
Encorate is an antiepileptic drug containing sodium valproate, prepared in the form of film-coated tablets, with a content of 200mg; 300mg; 500mg corresponds to Encorate, Encorate 300 and Encorate Chrono 500.
The active ingredient Sodium valproate in Encorate can affect the synthesis and metabolism of a naturally occurring amino acid that acts as a transmission inhibitor. neurotransmitter called Gamma aminobutyric acid (abbreviated as GABA), thereby inhibiting the activity of this amino acid.
Encorate is used as follows:
Treatment of generalized, partial epilepsy or other types of epilepsy. Prevention of febrile convulsions in children, myoclonus. Prophylactic treatment of manic states in patients with bipolar affective disorder. Note, women of reproductive age should only use the drug if the disease is severe or does not work with other drugs. Encorate is contraindicated in people who are allergic to the drug, people with acute liver failure, drug-induced hepatitis, and Porphyrin metabolism disorders.
Encorate là thuốc thuộc nhóm thuốc động kinh, được sử dụng để điều trị các thể động kinh
2. How to use and dose Encorate
Encorate is used orally, taken directly with water. Dosage as prescribed by the doctor is as follows:
For adults: The initial indicated dose is 600mg/day, used several times a day. Every 3 days, increase the dose by 200mg until seizures are controlled. Make sure the dose is in the range of 1-2g/day and the maximum is 2.5g/day. For children over 20kg: The initial dose of Encorate is 400mg/day, then increase the dose until seizures are controlled. Make sure the dose is in the range of 20-30mg/kg/day and up to a maximum of 35mg/kg/day. For children under 20kg: The usual dose is 20mg/kg/day. However, if the patient is severely ill and the blood level of valproic acid is manageable, the dose may be increased. For patients with renal impairment: Dosage is adjusted accordingly. Encorate combination therapy is guided as follows:
Increase dose slowly until target dose is reached after 2 weeks if previous treatment with other antiepileptic drugs. May be increased by 5-10 mg/kg/day if necessary if co-treatment with other enzyme-inducing antiepileptic drugs. In case of discontinuation of enzyme inducers, a lower dose should be maintained to achieve seizure control.
3. Dealing with missed dose or overdose of Encorate
Encorate is a rapid seizure reliever, so if taken in overdose, exceeding the threshold 10 to 20 times the maximum recommended amount can lead to severe central nervous system depression. and cause respiratory failure, even death. In case of an overdose and in an emergency, immediate emergency contact is required and family members need to prepare the medications that the patient is taking.
For the case of forgetting a dose of Encorate, it should be taken as soon as you remember, but if it is time for the next dose, skip it and do not increase the dose on your own.
4. Side effects of the drug Encorate
Encorate drug can cause some side effects in internal organs, nervous system such as:
Liver: Impaired function and can cause death. Manifestations of severe liver toxicity such as lethargy, loss of consciousness, drowsiness, weakness, vomiting, edema, abdominal pain, anorexia, jaundice. Central nervous system: The body loses coordination and coordination, the patient has manifestations such as lethargy, tremors, hallucinations, stupor, or confusion, convulsions. Some less common side effects in the nervous system such as loss of hearing function, agitation, coma, encephalitis, brain atrophy cause memory loss. Intestinal, stomach: Encorate drug can cause side effects that are appetite leading to weight gain, stomach and intestinal irritation, especially in the initial treatment, but vomiting, abdominal pain are very rare. Skin: Hair loss, rarely reported side effects are toxic immune disorders, skin necrosis, erythema, Stevens-Johnson syndrome, vasculitis. Vascular: Rarely causes leukemia, blood cell and blood fibrinogen depletion. In addition, Encorate can cause some other undesirable side effects such as pancreatitis, increased ammonia in the blood, edema, amenorrhea, Fanconi syndrome (reversible), appendicitis. Patients should contact their doctor immediately if they see any unusual symptoms after taking the drug.
Bệnh nhân có thể bị rụng tóc khi sử dụng thuốc encorate
5. What precautions should be taken when using Encorate?
Before, during and after taking Encorate, it should be noted:
Check liver function before drug treatment, every 6 months, especially in at-risk groups including children (especially children) is under 3 years old), people with metabolic disorders, encephalopathy, epilepsy, mental retardation, congenital diseases. Discontinue treatment with Encorate if the prothrombin time is abnormally prolonged, especially when other disorders occur or the ammonia level in the blood is elevated and there are symptoms of disturbances in consciousness, vomiting, body. loss of air conditioning. When the patient has abdominal pain, it is necessary to conduct a pancreatic enzyme test to evaluate. Encorate has the ability to prolong bleeding time and reduce platelet count. In patients with diabetes, a urine test may give a false positive result. Encorate is used to treat epilepsy and prevent convulsions in children with high fever, muscle twitching. In addition, the drug is also used for the prophylaxis of mania in patients with bipolar affective disorder.
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