What are the uses of Phenylbutazone?

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Phenylbutazone is commonly used in the treatment of acute ankylosing spondylitis and gout. What is Phenylbutazone and how is it used?

1. What is Phenylbutazone?

Phenylbutazone is a nonsteroidal anti-inflammatory drug (NSAID) that helps reduce inflammation and pain caused by ankylosing spondylitis when the use of other medications may no longer be appropriate.
Phenylbutazone is indicated in the following cases:
Treatment of back pain and ankylosing spondylitis. Acute gout. Phenylbutazone is contraindicated in the following cases:
People who are allergic to phenylbutazone or to any other anti-inflammatory drugs (such as aspirin, ibuprofen, celecoxib), or to any other ingredient in its ingredients. drug part. You have or have ever had stomach or intestinal problems such as peptic ulcers, stomach or intestinal bleeding, or severe gastritis, especially if you have taken an NSAID before. Have an inflammatory bowel disease such as ulcerative colitis or Crohn's disease. People with serious liver or kidney problems. People with swelling or high blood pressure can affect the heart. People with any thyroid disease. People who have ever had a bleeding disorder, or any other disorder that affects the blood or blood cells. People with Sjogren's syndrome, which is a disorder in which the mouth and eyes become extremely dry. People with asthma and know that non-steroidal anti-inflammatory drugs cause an asthma attack, rash, swelling or inflammation of the nasal passages. Are using any other non-steroidal anti-inflammatory drugs (NSAIDs). Pregnant women more than 6 months.

2. Dosage and usage of Phenylbutazone

The usual adult starting dose of Phenylbutazone for the first 48 hours is 400 - 600mg per day in divided doses. The doctor will then proceed to reduce the dose to the minimum effective level, usually 200-300mg per day in divided doses.
For severe arthritis, Phenylbutazone will be used as follows:
At first, use 100mg / time orally about three or four times a day. Some people may need a higher dose of 200mg 3 times a day. After your arthritis improves, your doctor may direct you to use a lower dose for a while before stopping treatment altogether. Phenylbutazone should not be taken for longer than a few weeks. Phenylbutazone Gout Treatment:
Use 400mg for the first dose, then use 100mg every four hours for a week or less. Phenylbutazone is not suitable for children under 14 years of age.
Elderly patients are at higher risk of side effects from Phenylbutazone and should take the lowest effective dose for the shortest possible time with additional monitoring by a physician.
How to use Phenylbutazone:
Take the medicine during or right after a meal. Swallow the tablet whole and drink with plenty of water. Your doctor may ask you to use antacids at the same time. When using an overdose of Phenylbutazone, you may experience the following symptoms:
Abdominal pain, chest pain, agitation, ataxia, cholestatic jaundice, coagulopathy, colitis. Coma, somnolence, dermatitis, diarrhea, gastrointestinal disturbances, erythema multiforme, exfoliative dermatitis. Stool discoloration, gastritis, hematuria, bleeding, hyperventilation, hypotension. Hypothyroidism, lichenoid eruption, pemphigus, jaundice, peritonitis, pericarditis. Photosensitivity, rhabdomyolysis, convulsions, stomatitis, toxic epidermal necrolysis, respiratory arrest, urine discoloration. Pale lips, skin and fingernails, constant and severe headache. What to do in case of a Phenylbutazone overdose: If you think an overdose of Phenylbutazone has occurred, call your doctor or get medical attention right away. Treatment is mainly supportive, which may require multiple doses of coal to reduce the risk of delayed toxicity.
If you take phenylbutazone regularly, and forget a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and use your next dose at the normal time.

3. Phenylbutazone side effects

Common side effects of Phenylbutazone include:
Abdominal discomfort or hangover, heartburn, diarrhea, gas, constipation. Dizziness, drowsiness, feeling tired or weak. Uncommon No information found. Rare side effects of Phenylbutazone include:
Allergic reactions: Rash, urticaria, itching; red, swollen, blistering, or peeling skin that may be accompanied by a fever; wheeze; chest tightness or a lump in the throat; trouble breathing, trouble swallowing, or unusual hoarseness; or swelling of the face, lips, mouth, tongue, or throat. Bleeding: Such as vomiting or coughing up blood, bloody urine; stools that are black, red, or tarry; bleeding tooth ; unusual vaginal bleeding; bruises on the skin that are unexplained or become larger; or bleeding you can't stop. Kidney-urinary: Inability to urinate, change in the amount of urine, blood in the urine, or a lot of weight gain. Liver: Vomiting or yellowing of the skin or eyes, dark urine, pale stools, Signs of high blood pressure such as a very severe headache or dizziness, fainting or vision changes. Shortness of breath Weight gain Swelling in hands or feet. Chest pain or tightness. Difficulty speaking or thinking, changes in balance, weakness on one side of the body, drooping on one side of the face or blurred vision, vision changes, ringing in the ears. There is a burning, numb, or tingling sensation. Hallucinations, cognitive disturbances. Abdominal pain, stomach pain. Stevens-Johnson syndrome Toxic epidermal necrolysis.

4. Some notes when using Phenylbutazone:

Phenylbutazone may increase your risk of heart and blood vessel problems such as heart attack and stroke that can be fatal. Your risk of these problems may be greater if you have heart disease or are at risk for heart disease. However, this risk can also be raised even if you do not have heart disease or are not at risk for heart disease. The risk of these problems may occur during the first weeks you use Phenylbutazone and may be greater with higher doses or long-term use. Do not use phenylbutazone right before or after heart surgery. Phenylbutazone may increase your risk of serious and sometimes deadly stomach or intestinal problems such as ulcers or bleeding. This risk is higher in older people and in people who have had a previous stomach or intestinal ulcer or bleeding. However, this problem can still occur without warning. The above are important notes when using Phenylbutazone. You need to keep in mind for the use of the drug to achieve good results.

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