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Actrapid is used in the treatment of patients with diabetes. Use Actrapid exactly as prescribed by your doctor or pharmacist to ensure safety for your health and effective treatment of the disease.
1. What is Actrapid?
Actrapid is produced in the form of a solution for injection contained in a vial, a clear, colorless solution, 1ml of solution containing 100IU of human insulin. The drug is packaged in the specification of 1 vial containing 10ml equivalent to 1,000 IU of human insulin.
The drug works to reduce glucose easily after insulin binds to receptors on muscle and fat cells, and it also inhibits glucose production from the liver. Actrapid is a fast-acting insulin, the drug takes effect in 1/2 hour, reaches its maximum effect within 1.5-3.5 hours and takes effect about 7-8 hours after injection.
2. Indications and contraindications of Actrapid
Actrapid is indicated in the following cases:
Diabetes. Actrapid is contraindicated in the following cases:
People with hypersensitivity to the active substance or any of the excipients of the drug.
3. Dosage and how to use Actrapid
Actrapid is used by injection under the skin. You need to change the injection site in the area to reduce the risk of swelling or skin indentations. The best places for you to inject Actrapid are: Abdomen, buttocks, front of thighs, or upper arms. The drug will work faster if you inject it in the abdomen.
Actrapid can also be used intravenously in special cases and must be done by medical personnel.
How to inject Actrapid alone or mixed with long-acting insulin:
Make sure you are using the correct syringe with the respective scale for the insulin injections; Fill the syringe with the amount of medicine prescribed by the doctor; Perform subcutaneous insulin injections according to the technique as instructed by your doctor or nurse; There should be a main or light carbohydrate meal within 30 minutes of each Actrapid injection. Actrapid is a rapid-acting insulin and can be used in combination with long-acting insulin products.
The dose of Actrapid is individual and determined according to the needs of the patient. The insulin requirement of each patient is usually between 0.3 and 1.0 IU/Kg/day. Daily insulin requirements may be higher in insulin-resistant patients and lower in patients who produce a surplus of endogenous insulin.
Adjust the dose in the following cases:
Comorbidities, especially infections and fever, will often increase your insulin requirements; Comorbidities in the kidneys, liver or affecting the adrenal, pituitary or thyroid glands may require a change in your insulin dose; Your dose of Actrapid may also need to be adjusted if you change your usual physical activity or diet; Dose adjustments may also be needed when you are switching from one insulin preparation to another. Overdosage with Actrapid cannot be clearly established, however hypoglycemia can develop in successive episodes if you take a dose that is too high for your body's needs:
Phase of mild hypoglycaemia , which can be treated with oral glucose or sugary products. Therefore, when you have diabetes, you are often advised to carry sugary products with you at all times; Severe episodes of hypoglycemia, when you are unconscious, can be treated with an intramuscular or subcutaneous injection of glucagon (0.5 to 1mg) given by someone who has been trained in injection or injection glucose administration. intravenous infusion by a healthcare professional. You will have to use intravenous glucose, if you do not respond to glucagon within 10-15 minutes; When you regain consciousness, you will be given food containing carbohydrates to prevent relapse. If you forget a dose of Actrapid, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose of Actrapid at the scheduled time.
4. Actrapid side effects
When using Actrapid, you may experience unwanted effects including:
Rare immune system disorders such as urticaria, rash; Very rare anaphylactic reactions; Metabolic and nutritional disorders: Hypoglycaemia very common; Nervous system disorders such as peripheral neuropathy are uncommon; Eye disorders such as refractive disorders are uncommon, very rarely diabetic retinopathy; Skin and subcutaneous tissue disorders such as dystrophy are uncommon; Injection site reactions are uncommon; Edema is uncommon.
5. Actrapid interactions with other drugs
The following drugs may reduce your need for insulin:
Oral diabetes medications; monoamine oxidase inhibitor (MAOI); Non-selective beta-blockers; Angiotensin-converting enzyme (ACE) inhibitors; Salicylates; Anabolic steroids; Sulfonamides. The following drugs may increase your need for insulin:
Oral contraceptives; Thiazides; Glucocorticoids; Thyroid hormone ; Substances with sympathomimetic effects; Growth hormone; Danazol. Beta-blockers may mask symptoms of hypoglycemia and delay recovery.
Octreotide/lanreotide may increase or decrease the need for insulin.
Alcohol may increase or decrease the hypoglycemic effect of Actrapid.
6. How to store Actrapid vials When in use, you should not keep Actrapid vials in the refrigerator. Actrapid vials can be stored at room temperature (not exceeding 30°C) for 6 weeks after first opening; When not in use, you should store the Actrapid vial in the refrigerator at 20C to 80C (not too close to the freezer), do not freeze the vial; Keep the Actrapid vial in the carton to protect from light; Actrapid vials must be protected from excessive heat or light; Keep Actrapid out of reach and sight of children; Do not use Actrapid after the expiry date indicated on the label/carton box. The above are the uses and notes to use when using Atorcal 20mg. This is a drug to be used under the prescription of a doctor, you should not use it on your own. Any drug can have adverse effects on the body, so use it only when needed.
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