What does Xonatrix do?

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Xonatrix 120 is prepared in the form of film-coated tablets, with the main ingredient being Fexofenadine hydrochloride 120mg. It is used for the symptomatic treatment of seasonal allergic rhinitis and chronic idiopathic urticaria in persons 6 years of age and older.

1. What does Xonatrix do?

Xonatrix-120 medicine has the ingredient Fexofenadine (2nd generation antihistamine). Xonatrix is ​​indicated for use in: Symptomatic treatment of seasonal allergic rhinitis or chronic idiopathic urticaria in adults and children 6 years of age and older.
Xonatrix is ​​contraindicated in patients with hypersensitivity to fexofenadine, terfenadine or other ingredients in the drug.

2. How to use and dose Xonatrix

Usage: Orally. Patients should not take the drug with fruit juice. The time to take the drug does not depend on the meal, but the patient should not take it too close (within about 15 minutes) with antacids containing magnesium and aluminum.
Dosage:
Allergic rhinitis: Adults and children over 12 years old: Dosage 60mg x 2 times/day or 180mg/time/day; Children under 12 years old: The dosage form is not suitable for the indicated dose; Chronic idiopathic urticaria: Adults and children over 12 years old: Dose 60mg x 2 times/day or 180mg/time/day; Children under 12 years old: The dosage form is not suitable for the indicated dose; Elderly and renal failure: Children from 12 years old and older and adults with renal failure, the elderly: Initial dose is 60mg/time/day, adjust dose according to renal function; Children under 12 years old: The dosage form is not suitable for the indicated dose; *Note: The above dose of Xonatrix is ​​for reference only. The specific dose of the drug will be prescribed by the doctor depending on the condition, the progress of the disease in each patient.
Overdose: Stop taking the drug, contact a doctor immediately or take the patient to the nearest medical center. Doctors will use some common methods to remove the unabsorbed drug from the digestive tract, supportive treatment combined with symptomatic treatment. The doctor may opt for hemodialysis to reduce the patient's blood levels of the drug.
Missed dose: If you forget to take a dose, the patient should skip the missed dose and take the next dose of Xonatrix at the right time as scheduled.

3. Xonatrix drug side effects

When using Xonatrix medicine, patients may experience some unwanted side effects:
Common: Drowsiness, headache, fatigue, insomnia, dizziness, nausea, indigestion, easy viral infection (cold, flu), susceptible to upper respiratory infections, menstrual cramps, cough, fever, itchy throat, sinusitis, otitis media, back pain; Uncommon: Fear, nightmares, sleep disturbances, dry mouth, abdominal pain, generalized fatigue; Rare: Urticaria or skin rash, skin pruritus, angioedema, dyspnea, chest tightness, anaphylaxis; Unknown frequency: Heart palpitations, diarrhea,... When experiencing the above side effects, the patient should stop using the drug, immediately notify the doctor or go to the nearest hospital for timely treatment. time.

4. Be careful when using Xonatrix

Before using Xonatrix, patients should pay attention to:
Caution, appropriate dose adjustment when using the drug for people with impaired renal function because of increased plasma drug concentration (due to prolonged half-life). long). Caution should be exercised when administering the drug to elderly patients (over 65 years of age) because they often have impaired renal function; The safety and effectiveness of Xonatrix in children under 6 months of age have not been established; The drug should be discontinued at least 24-48 hours before conducting intradermal antigen tests; Using Xonatrix can make psoriasis worse; Antihistamines such as Xonatrix can cause heart palpitations, so caution should be exercised when using them for people with a history or existing cardiovascular disease; Xonatrix medicine contains lactose monohydrate, so it should not be used in patients with Lapp lactase deficiency, galactose intolerance or glucose - galactose malabsorption; Be careful when using Xonatrix medicine for drivers, operating machines; With caution when taking Xonatrix medicine to pregnant and lactating women, consult your doctor before deciding to take the drug.

5. Xonatrix drug interactions

Some Xonatrix drug interactions patients need to pay attention to:
The active ingredient fexofenadine in Xonatrix is ​​not metabolized by the liver, so the drug does not interact with other drugs metabolized by the liver; Erythromycin and ketoconazole will increase fexofenadine plasma concentrations but do not alter the QT interval. The concentration of fexofenadine may be increased by verapamil, erythromycin, ketoconazole and p-glycoprotein inhibitors; There are no drug interactions between fexofenadine and omeprazole. Do not use fexofenadine concomitantly with magnesium and aluminum-containing antacids because of reduced absorption of fexofenadine; Fexofenadine may reduce the concentration of acetylcholinesterase inhibitors, betahistine; Fexofenadine may increase the concentration of alcohol, anticholinergic agents and central nervous system sedatives; Fexofenadine may be reduced by acetylcholinesterase inhibitors, antacids, amphetamines, grapefruit juice, rifampin; Fruit juices (oranges, apples, grapefruits) can reduce the bioavailability of fexofenadine by up to 36%. In addition, the use of fexofenadine with alcohol should be avoided because of the increased risk of sedation (sedation). Xonatrix medicine works to quickly relieve allergic rhinitis, atopic dermatitis, runny nose, sneezing, nasal congestion,... use time, dose, ... to ensure the best treatment effect.