What does Japrolox 60mg do?

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1. Uses of Japrolox 1.1. Indications Japrolox contains the active ingredient loxoprofen 60mg is indicated in the treatment of the following conditions:
Pain relief and anti-inflammatory in symptoms and disorders including: Osteoarthritis - arthritis, rheumatoid arthritis, toothache, periarthritis of the shoulder, neck - arm syndrome; Pain relief and anti-inflammatory after trauma, surgery; Antipyretic and analgesic in disorders such as acute respiratory infections (including acute upper respiratory tract infections associated with acute bronchitis). 1.2. Pharmacodynamics Active ingredient loxoprofen sodium hydrate has strong analgesic, anti-inflammatory and antipyretic activity, especially analgesic effect. After absorption into the systemic circulation, the drug is converted to an active and potent metabolite. Specifically as follows:
Analgesic effect: Loxoprofen has been shown to have an ED50 dose of 0.13 mg/kg in the Randoll - Selitto test (exercise pressure on inflamed rat legs orally). The analgesic effect of this active ingredient is 10 to 20 times higher than that of other similar drugs such as naproprofen, ketoprofen, indomethacin. Evaluation of the rat wound test (orally) showed that loxoprofen was 3 to 5 times more effective in pain relief than indomethacin and ketoprofen. The analgesic effect of the drug is concentrated in the periphery. Anti-inflammatory effects: The anti-inflammatory effects of loxoprofen have been shown to be comparable to those of naproprofen and ketoprofen in acute inflammatory conditions such as adjunctive arthritis and carrageenin-induced edema. Antipyretic effect: The antipyretic effect of loxoprofen has been shown to be comparable to that of naproprofen and ketoprofen and is approximately 3 times greater than that of indomethacin in yeast-induced fever (rat test). loxoprofen is an inhibitor of the biosynthesis of prostaglandins, the site of action of which is the oxidative ring. Following oral administration, loxoprofen sodium hydrate is absorbed from the gastrointestinal tract as unchanged compound and causes minimal gastric irritation. The drug is then converted to an active trans OH isomer metabolite (SRS conjugate form) with a potent inhibitory effect on prostaglandin biosynthesis responsible for the pharmacological action of the drug.

1.3. Pharmacokinetics Absorption and metabolism: Scientific studies have shown that Japrolox is rapidly absorbed after oral administration and its metabolites are detected in the blood. The time to reach peak plasma concentrations is approximately 30 minutes for loxoprofen and 50 minutes for the trans OH isomer metabolite. The half-life of the drug is about 1 hour and 15 minutes for both substances. Drug Metabolizing Enzymes: Loxoprofen acts as a substrate for cytochrome P450 isoforms (CYP1A1/2, 2B6, 2A6, 2C19, 2C8/9, 2D6, 2E1 and 3A4). The plasma protein binding rates are 97% and 92.8% for loxoprofen, the trans-OH isomer, respectively. Japrolox is excreted in the urine as the glucuronate conjugate of loxoprofen and its metabolite.
2. Dosage of Japrolox Medicine Japrolox is used to be taken orally in a dose that depends on the condition and age of the patient. Specifically as follows:
Pain relief and anti-inflammatory: The dose of loxoprofen 60mg in adults is 60mg/time x 3 times/day. Dosage may be adjusted according to the symptoms and age of the patient. The drug should be taken after meals for better absorption and to avoid the risk of gastrointestinal ulceration. Antipyretic and analgesic: The adult dose of loxoprofen is 60 mg/time as needed. The recommended dose for antipyretic and analgesic effects is twice daily, up to 180 mg/day in some cases. The drug should be taken after meals for better absorption. In case of overdose of japrolox 60mg, it should be treated with the usual measures such as gastric lavage, using activated charcoal and increasing excretion, monitoring the patient for timely treatment.

3. Side effects when taking Japrolox Some side effects that may be encountered when taking japrolox are as follows:
Common side effects (ADR ratio > 1/100):
Gastrointestinal symptoms such as: stomach pain, upset stomach, vomiting or nausea, loss of appetite; Urticaria, edema, rash and somnolence. Side effects of unknown frequency:
Anaphylactic symptoms such as shock, urticaria, decreased blood pressure, dyspnea, laryngeal edema; Leukopenia, hemolytic anemia, thrombocytopenia; Toxic epidermal necrolysis (Lyell's syndrome) and ocular mucosal syndrome; Renal syndrome, acute renal failure, interstitial nephritis; Congestive heart failure; Severe peptic ulcers such as stomach bleeding, small bowel bleeding, vomiting and bloody stools; liver dysfunction or sudden hepatitis; Aseptic meningitis (nausea and vomiting, headache, fever, loss of consciousness); Narrow and/or obstruction associated with ulceration of the small and large intestine. In case of symptoms of side effects after taking the drug, the patient should stop using the drug and immediately notify the doctor or go to the medical facility for timely treatment.

4. Note when using Japrolox 4.1. Contraindications Contraindicated to use Japrolox for the following cases:
Patients with gastrointestinal ulcers; The patient has severe blood abnormalities; Patients with liver dysfunction; Patients with kidney failure; Hypersensitivity to any ingredient of japrolox; Patients with asthma or a history of aspirin-induced asthma (induce asthma attacks with non-steroidal anti-inflammatory drugs...); Women who are in the last stage of pregnancy. 4.2. Patients should note that Japrolox in particular and anti-inflammatory analgesics in general only treat symptoms, not the cause of the disease. When using japrolox in the treatment of chronic diseases (osteoarthritis, rheumatoid arthritis), the following issues should be noted:
Patients on long-term treatment with japrolox need to perform periodic laboratory tests. laboratory tests such as blood count test, urine test, liver function test... In case there is any abnormality, the patient should take appropriate measures such as reducing the dose or stopping taking the drug; In case of using japrolox in the treatment of acute diseases, it should be noted: The drug should be used for acute pain, inflammation and fever. Based on the principle of avoiding long-term use of drugs like other non-steroidal anti-inflammatory drugs; Care should be taken to closely control the patient's clinical symptoms when taking the drug to reduce the risk of side effects. Specifically, the patient may have heart failure, hypothermia, cold limbs... so it is necessary to carefully monitor clinical symptoms after taking the drug, especially in the elderly who have high fever or high fever. the patient is debilitated; Avoid concomitant use of japrolox and other anti-inflammatory analgesics; Cardiovascular thromboembolic risk: Systemic administration of japrolox in particular and non-aspirin (non-aspirin) non-steroidal anti-inflammatory drugs in general increases the risk of cardiovascular events (including stroke and myocardial infarction). heart) can lead to death. This risk appears early in the first few weeks of taking the drug and increases with the duration of the drug, with the risk of cardiovascular thrombosis being more prominent when used at high doses. Therefore, patients should be alerted to the symptoms of cardiovascular events and seek medical attention as soon as these symptoms appear.

4.3. Drug interactions Japrolox 60mg can cause some drug interactions as follows:
Anticoagulants warfarin, coumarin: Concurrent use of japrolox and anticoagulants increases the effectiveness of these drugs. The reason is that the inhibitory effect of prostaglandin biosynthesis of japrolox inhibits platelet aggregation and reduces coagulation, thereby increasing the anticoagulant effect of both these drugs. Hypoglycemic agents Sulfonylurea, Tolbutamide and others: Concomitant use of japrolox and hypoglycemic agents increases the effectiveness of these agents. New generation quinolone antibiotics: Concomitant use of japrolox and newer quinolone antibiotics such as enoxacin increases the convulsive effects of these drugs. Methotrexate: Concomitant use of japrolox and methotrexate increases plasma concentrations of methotrexate, leading to an increased risk of adverse drug reactions. Lithium and lithium carbonate preparations: Plasma concentrations of lithium are increased when co-administered with japrolox, resulting in an increased risk of adverse drug events. Thiazide, hydorchlothiazide and hydroflumethiazide diuretics: The diuretic-antihypertensive effect of these drugs is increased when combined with Japrolox 60mg. Antihypertensives (Angiotensin II receptor antagonists, ACE inhibitors): The antihypertensive effect of this drug may be reduced, renal function impaired when used with japrolox.
5. Impact of japrolox on special subjects The effects of japrolox 60mg on special subjects are as follows:
Pregnant women: Only use japrolox 60mg in pregnant women when needed. Remember that the benefits of treatment outweigh the risks. Lactation: Avoid use in lactating women. If the drug is necessary, the patient should stop breastfeeding before using the drug. Driving and using machines: There are no specific reports on the effect of the drug on the ability to drive and use machines. Japrolox contains the active ingredient loxoprofen, which belongs to the group of non-steroidal anti-inflammatory drugs. The drug is indicated in the treatment of osteoarthritis, rheumatoid arthritis, arthritis around the shoulder. To ensure the effectiveness of treatment and avoid drug interactions, patients need to strictly follow the instructions of the doctor or pharmacist.
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