What diseases does Cheklip 20 treat?

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Cheklip 20 medicine has the main ingredient is Atorvastatin. The drug is effective as a dietary supplement to reduce total cholesterol, LDL, apolipoprotein B, triglycerides and increase HDL in people with primary hypercholesterolemia or mixed dyslipidemia.

1. What is Cheklip 20?

Ingredients of Cheklip 20 include:
Atorvastatin 20mg; Excipients 1 capsule. Dosage form:
Film coated tablets. Pharmacodynamics of Cheklip 20:
Active ingredient Atorvastatin is a drug belonging to the group of HMG-CoA reductase inhibitors. Pharmacokinetics of Cheklip 20:
Absorption: Atorvastatin is rapidly absorbed from the gastrointestinal tract and is not affected by food. The bioavailability of Atorvastatin is rather low, due to extensive first-pass metabolism (with more than 60%). The concentration of the drug peaks in the serum after about 1 to 2 hours; Distribution: Atorvastatin has a strong plasma protein binding capacity of over 98%. Pharmacokinetics Atorvastatin is lipophilic so it can cross the blood-brain barrier; Metabolism: Cheklip 20 is extensively metabolised in the liver to inactive or inactive metabolites; Elimination: Cheklip 20 is eliminated mainly in the faeces and to a small extent in the kidneys.

2. What diseases does Cheklip 20 treat?

Cheklip 20 is indicated in the treatment of the following diseases:
Adjunctive treatment to diet to reduce total cholesterol, LDL, apolipoprotein B, triglycerides; increased HDL in people with primary hypercholesterolemia or mixed dyslipidemia (types IIa and IIb); reduced blood triglycerides type IV; Treatment of primary dyslipidemia beta (type III); Adjuvant therapy in combination with other lipid-lowering measures to reduce total and LDL cholesterol in homozygous familial hypercholesterolaemia.

3. How to use and dose Cheklip 20

3.1. How to take Cheklip 20 Cheklip 20 medicine is made in the form of tablets and is not affected by food, so you can take it at any time of the day, regardless of the meal.
3.2. Dosage of Cheklip 20: For hypercholesterolemia (heterozygous familial and non-familial) and mixed dyslipidemia:
The recommended starting dose is 10-20mg, 1 time/day. Those who need a large reduction in LDL cholesterol (over 45%) can start with a dose of 40mg and use it once a day. The therapeutic dose range of Cheklip 20 is 10-80mg once daily. After initiation of therapy and/or an increase in the dose of Atorvastatin, blood lipids should be assessed over a period of 2 to 4 weeks for appropriate dose adjustment. For homozygous familial hypercholesterolemia:
The therapeutic dose is 10-80mg/day and should be combined with other lipid-lowering measures. Combination therapy:
Atorvastatin can be combined with Resin to increase the effectiveness of treatment. The therapeutic dose of Cheklip 20 in patients with renal failure:
No dose adjustment is required.

4. Undesirable effects when using Cheklip 20

Cheklip 20 is generally well tolerated, side effects are usually mild and transient. You may have side effects when using Cheklip 20 as follows:
Digestive disorders: Constipation, flatulence, indigestion, abdominal pain, nausea, vomiting, ..; Psychiatric disorders: Forgetfulness, confusion; Headache, dizziness, fatigue, weakness, weakness.

5. Cheklip 20 . drug interactions

Cheklip 20 may interact with the following drugs and foods:
Anticoagulants, Indandione combined with the active ingredient Atorvastatin will increase bleeding time or prothrombin time. Therefore, it is necessary to monitor prothrombin time in people using concomitant anticoagulants; Cyclosporine, Erythromycin, Gemfibrozil, immunosuppressants, Niacin: Co-administration with Cheklip 20 increases the risk of myopathy; Digoxin: Co-administration with Cheklip 20 causes a slight increase in serum digoxin concentrations; Grapefruit juice: Grapefruit juice contains one or more CYP3A4 inhibitors, which can increase plasma concentrations of the active ingredient Atorvastatin, especially with consumption of grapefruit juice above 1.2l per day. . Cyclosporine: Active substance Atorvastatin and its metabolites Atorvastatin are substrates of the OATP1B1 transporter. OATP1B1 inhibitors (eg, cyclosporine) may increase the bioavailability of Atorvastatin. Atorvastatin AUC was significantly increased with the combination of Atorvastatin 10mg and Cyclosporine 5.2mg/kg/day. Oral contraceptives: Active ingredient Atorvastatin increases the AUC levels of Norethindrone and Ethinyl estradiol. Colchicine: Cases of myopathy, including rhabdomyolysis, have been reported clinically with co-administration of Cheklip 20 with Colchicine.

6. Some notes when using Cheklip 20

Contraindications of Cheklip 20:
People with a history of allergy or hypersensitivity to any of the ingredients in the drug; People who are suffering from liver failure, kidney failure, increased transaminase; Pregnant women and lactating mothers: Cheklip 20 should not be used in pregnant women. Women of childbearing age are advised to use contraception while taking medicines containing Atorvastatin. If you become pregnant while taking Cheklip 20, discontinue use immediately and notify your treating physician; Breastfeeding mothers; Children under 18. Be careful when using Cheklip 20 drug in the following cases:
Before treatment with Cheklip 20, it is necessary to pay attention to exclude the causes of secondary dyslipidemia and to quantify the lipid indices. periodically with a time interval of not less than 4 weeks; During combination therapy with HMG-CoA reductase inhibitors, if creatine kinase is elevated, myositis develops, or serum liver enzymes are elevated 3 times the upper limit of normal, the dose should be reduced or discontinued. treatment with the drug Cheklip 20 ; Cheklip 20 should be used with caution in people with liver dysfunction, heavy alcohol consumption; You need to have a reasonable diet before treatment with Cheklip 20. Maintain this regimen throughout treatment with the drug; If you become pregnant while taking Cheklip 20, stop using the medicine and call your doctor right away. Atorvastatin may pose a risk of harm to an unborn baby. Do not breastfeed your baby while taking Cheklip 20 ; If you are going to have surgery, tell your doctor that you are taking Atorvastatin. If you need to be hospitalized due to serious injury or infection, tell your treating doctor that you are taking Atorvastatin. Avoid the use of alcoholic beverages. Cheklip 20 is generally well tolerated in the treatment of these conditions. To ensure effective treatment and avoid unwanted side effects, you should carefully read the instructions or follow the doctor's instructions.

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