What disease does Evaldez treat?

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Evaldez medicine 50mg with the main ingredient is levosulpiride to help relieve symptoms of functional dyspepsia, abdominal distension, discomfort, heartburn, belching... and acute and chronic schizophrenia. Evaldez is available in the form of 50mg tablets.

1. What active ingredients does evaldez contain?

Ingredients in each Evaldez tablet contains 50mg of Levosulpiride and excipients such as: microcrystalline cellulose, croscarmellose sodium, magnesium stearate, povidone, silicon dioxide, sodium lauryl sulfate...
Levosulpiride is an active ingredient of the benzamide group. is a sulpiride isomer with antipsychotic effects through selective blocking of dopamine D2 receptors in the brain. Levosulpiride can be considered as an intermediate between neuroleptic drugs (neuroleptics) and antidepressants because levosulpiride has both effects.
Evaldez drug has the characteristics of slow absorption from the gastrointestinal tract, low bioavailability. The drug evaldez is rapidly distributed into tissues. It crosses breast milk but has a poor blood-brain barrier. Evaldez is eliminated in the urine and faeces mainly as unchanged drug (95%).

2. What does evaldez do?

What disease does evaldez treat? Evaldez is used to relieve symptoms of functional dyspepsia such as abdominal distention, epigastric discomfort, heartburn, belching, nausea or vomiting.
In addition, the drug evaldez is also effective in treating acute and chronic schizophrenia.

3. Dosage of the drug evaldez

Dosage of the drug evaldez for adults:
Effect of reducing symptoms in functional dyspepsia: using a dose of 75mg/day, divided into 3 times; Effects on treatment of acute and chronic schizophrenia: using a dose of 200-300 mg/day, divided into 3 times; Dosage of evaldez for children over 14 years: Reduce dose.
Dosage of evaldez for children under 14 years: Not indicated.
Dosage of evaldez for patients with renal failure need to reduce dose or increase interval between administration of evaldez depending on the patient's creatinine clearance as follows:
Creatinine clearance 30 - 60 ml/min: use Levosulpiride dose is 2/3 of the normal dose; Creatinine clearance 10 - 30 ml/min: Levosulpiride dose Levosulpiride is 1/2 of the normal dose; Clearance less than 10 ml/min: Levosulpiride dose Levosulpiride 1/3 of the normal dose. Or increase the interval between doses by 1.5; 2 and 3 times the normal dose of Levosulpiride. However, in cases of moderate to severe renal impairment, it is best not to use levosulpiride if a more optimal alternative is possible.

4. Contraindications of the drug evaldez

Patients with hypersensitivity to any component of the drug evaldez ; Patients with adrenal myeloma; Patients with acute porphyria; People with depressed central nervous state, people who are comatose, alcohol poisoning and poisoning with neurosuppressive drugs.

5. Notes when using evaldez

In cases of renal failure, the dose of levosulpiride should be reduced and the patient's monitoring should be increased; if the patient has severe renal impairment, an intermittent therapy should be used. Enhanced monitoring of the following special patient populations:
Patients with epilepsy because this subject is likely to have a lowered seizure threshold; Elderly people using evaldez are prone to orthostatic hypotension, may be frequently somnolent, and are more susceptible to extrapyramidal effects; Subjects regularly drink alcohol or are using alcohol-containing drugs because evaldez will increase the feeling of drowsiness; In patients with high fever of unknown cause, evaldez should be discontinued to rule out possible neuroleptic malignant syndrome; In patients with hypomania, low doses of evaldez may worsen symptoms.

6. Evaldez side effects

Common side effects of evaldez with frequency > 1 in 100:
Side effects of evaldez on nerves: causing insomnia or somnolence; Side effects of evaldez on endocrine: Hyperprolactinemia, increased lactation, menstrual disorders or amenorrhea. Uncommon side effects of evaldez with frequency: 1/1000 < ADR < 1/100
Neurological side effects: evaldez overstimulation, extrapyramidal syndrome (patients) restless sitting, torticollis, eye rotation), Parkinson's syndrome; Side effects of the drug evaldez on the heart: The drug evaldez causes prolongation of the QT interval (causing arrhythmias, torsades de pointes). Rare side effects of evaldez with frequency < 1/1000
Endocrine side effects of evaldez: the drug causes gynecomastia in men; Neurological side effects of evaldez: the drug causes tardive dyskinesia, neuroleptic malignant high fever syndrome; Side effects of evaldez on blood pressure: the drug can cause orthostatic hypotension, bradycardia or arrhythmias; Other side effects of evaldez: Hypothermia, patients become sensitive to light, jaundice due to cholestasis.

7. Interactions of evaldez with other drugs

Sucralfate or antacids with aluminum and/or magnesium hydroxide will reduce the absorption of levosulpiride, in particular of evaldez, so evaldez should be taken about 2 hours after taking the antacids to avoid drug interactions. happen.
Lithium: This active ingredient may increase the extrapyramidal potential of levosulpiride because lithium increases the ability of levosulpiride to bind to dopaminergic D2 receptors in the brain, increasing the side effects of evaldez.
Levodopa: this is a competitive antagonist with levosulpiride and other neuroleptics, so the combination of levosulpiride with levodopa is contraindicated.
Alcohol will increase the sedative effect of evaldez, so avoid drinking alcohol and other alcoholic beverages during treatment with levosulpiride.
Antihypertensive drugs: May increase the antihypertensive effect and cause orthostatic hypotension when combined with evaldez
Other CNS depressants will increase the CNS depressant effect, causing after Bad results for people driving and operating machinery, so care should be taken when combining with evaldez.

8. Evaldez for pregnant and lactating women

Like other neuroleptic drugs, levosulpiride is an active ingredient that can cross the placenta and cause unwanted effects on the nervous system of the fetus, so evaldez should not be used during pregnancy, especially in pregnancy. Do not use during the first 16 weeks of pregnancy.
On the other hand, levosulpiride is likely to be distributed into breast milk in relatively large amounts and cause undesirable reactions in nursing infants, therefore nursing women should not take evaldez or discontinue nursing if use evaldez.

9. How to take an overdose of the drug evaldez

Overdosage of evaldez is common when patients take from 1 to 16 grams of the active ingredient, but there has been no death even at a dose of 16 grams. The clinical symptoms of evaldez overdose will vary depending on the dose:
Doses of 1 - 3 grams of evaldez can cause a state of dark consciousness, restlessness and rarely extrapyramidal symptoms; Doses of 3-7 grams of evaldez can cause more agitation, confusion and extrapyramidal syndrome; Doses above 7 grams may also experience coma and hypotension. Symptoms of evaldez overdose usually disappear within a few hours, and the coma is usually only seen with high doses of evaldez that can last up to 4 days.
Treatment of drug overdose evaldez: Levosulpiride does not have a specific antidote, so when taking the drug with a dose exceeding the prescribed dose, it is advisable to perform gastric lavage, give the patient activated charcoal (in this case the drug causes vomiting has no effect), alkalinize urine to increase drug elimination. If necessary, it is possible to use more drugs to treat Parkinson's syndrome and other supportive and symptomatic treatments.
Evaldez medicine 50mg is indicated for the treatment of symptoms of functional dyspepsia, abdominal distension, discomfort, heartburn, belching... and acute and chronic schizophrenia. To ensure the effectiveness of use, patients need to take the drug according to the prescription or as directed by the doctor or pharmacist.
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