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Cofidec 200mg medicine contains the main ingredient Celecoxib, which helps relieve the symptoms of ankylosing spondylitis, rheumatoid arthritis, osteoarthritis. Refer to drug use information for effective use.
1. What is Cofidec?
Cofidec drug contains the main active ingredient is celecoxib 200mg, has the effect of reducing symptoms in the treatment of diseases:
Rheumatoid arthritis Ankylosing spondylitis Osteoarthritis
2. How to take Cofidec 200mg
How to use: patients can drink 1 time or divided into 2 equal times. For rheumatoid arthritis, the dose should be divided equally into 2 times, which can be taken with or without meals. If taking a higher dose (ie 400mg / time, 2 times a day), it must be taken with meals to improve the absorption of the drug.
Specific dosage is as follows:
Osteoarthritis: The recommended daily dose is 200mg, taken once a day or divided into 2 times. Rheumatoid Arthritis: The recommended starting dose is 200mg daily in 2 divided doses. If necessary, it can be increased to 200mg, twice daily. Ankylosing spondylitis: The recommended daily dose is 200mg, taken once a day or divided into 2 times. In some patients with inadequate symptom relief, increase to 400 mg once daily or in 2 divided doses. In the absence of improvement after 2 weeks, consider other treatment options. The maximum recommended dose is 400 mg/day for all indications. Cofidec can be taken with/without food.
3. Side effects of Cofidec 200mg
Some unwanted effects of Cofidec 200mg such as: flatulence, diarrhea, sore throat, unexplained weight gain, fatigue, nausea, abnormal bleeding, itchy skin, loss of appetite, pain in the stomach. upper right stomach, yellowing of the skin or eyes, flu-like symptoms, fever, rash, hives, swelling of the face, throat, tongue, lips, eyes, hands, feet, hoarseness, difficulty swallowing or difficulty breathing, pale skin, fast heartbeat, cloudy, discolored or bloody urine, back pain, difficulty urinating, frequent urination, especially at night.
4. Contraindications of Cofidec 200mg
Cofidec 200mg drug is contraindicated in the following cases:
Hypersensitivity to any component of the drug. Patients with hypersensitivity to sulfonamides. Progressive peptic ulcer or gastrointestinal bleeding. Patients with a history of asthma, acute rhinitis, nasal polyps, angioedema, urticaria, or other allergic-type reactions following administration of acetylsalicylic acid or nonsteroidal anti-inflammatory drugs (NSAIDs) including COX inhibitors - 2 (cyclooxygenase-2). Women who are pregnant and women of childbearing potential, unless effective contraception is used. Lactation Patients with severe liver dysfunction (serum albumin < 25 g/l or Child-Pugh score ≥ 10). Patients with renal impairment with creatinine clearance < 30 ml/min. Patient has inflammatory bowel disease. Congestive heart failure (NYHA Class II-IV classifier (New York Heart Association)). Identified ischemic heart disease, peripheral artery disease and/or cerebrovascular disease.
5. Be careful when using Cofidec 200mg
Caution when using Cofidec 200mg in the following cases:
People with a history of peptic ulcer, or gastrointestinal bleeding Patients with a history of asthma, allergy to aspirin or an anti-inflammatory drug not steroid The elderly, debilitated, because it is easy to cause gastrointestinal bleeding and often the kidney function is reduced due to old age. Celecoxib may be nephrotoxic, especially when maintenance of renal blood flow requires the assistance of renal prostaglandins. Caution should be exercised when administering celecoxib to subjects with heart failure, renal failure, or liver failure. People with edema, water retention (such as heart failure, kidney failure) because the drug causes fluid retention, making the disease worse. People with extracellular water loss (due to strong diuretics). Dehydration should be treated prior to administration of celecoxib. As it is not known whether celecoxib reduces the risk of colorectal cancer associated with familial adenomatous polyposis, patient care should be continued as usual. That means endoscopic follow-up, prophylactic colectomy when needed. In addition, it is necessary to monitor the risk of cardiovascular complications (myocardial infarction, myocardial ischemia). Celecoxib has no intrinsic antiplatelet activity and thus does not protect against ischemic events, especially if high doses are used for a long time (400-800 mg/day). Note when using the drug for special cases (pregnancy, lactation, recent surgery...)
Pregnant women: To date, there are no adequate studies on celecoxib in pregnant women. pregnant. Therefore, celecoxib should be used during pregnancy only when the potential benefit outweighs the potential risk to the fetus. Do not use celecoxib in the last 3 months of pregnancy. Lactation: It is not known whether celecoxib is distributed into breast milk. Because celecoxib can have serious side effects in nursing infants, a benefit/harm balance should be made, either stopping breastfeeding, or discontinuing celecoxib. Children: Safety and efficacy have not been established in patients under 2 years of age. Hepatic impairment: Reduce dose by 50% in patients with moderate hepatic impairment. Do not use the drug in patients with severe liver failure. Patients with renal impairment: The drug is not recommended for patients with severe renal impairment. Patients with poor metabolisers of CYP2C9 substrates: Initiate treatment at half the recommended dose. Cofidec 200mg medicine contains the main ingredient Celecoxib, which helps relieve the symptoms of ankylosing spondylitis, rheumatoid arthritis, osteoarthritis. To ensure effective use and avoid side effects, you need to carefully read the instructions or consult a doctor or pharmacist for advice.
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