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Seroquel XR drug with the main active ingredient is Quetiapine which is effective in the treatment of psychosis. With this active ingredient, Seroquel XR is used to relieve symptoms of schizophrenia, bipolar disorder, anxiety disorders, and depression.
1. Uses of Seroquel XR
Seroquel XR belongs to the group of antipsychotics, the main ingredient is Quetiapine 50mg. This active ingredient restores the balance of natural neurotransmitters in the brain.
Seroquel XR is made in the form of peach-colored, capsule-shaped, convex tablets and is indicated for use in the treatment of the following conditions:
Schizophrenia; Bipolar disorder: Moderate to severe manic episodes, major depressive episodes. Prevention of recurrent episodes of mania and depression that have previously responded to quetiapine therapy; Major depressive disorder (MDD): Add-on treatment of major depressive episodes in cases where treatment with single-dose antidepressants has not yet yielded a good response; Generalized anxiety disorder (GAD). Seroquel XR drug works to reduce hallucinations, improve concentration, prevent mood swings, reduce anxiety and stress, help patients have more positive thoughts, regain balance in life.
2. Usage and dosage of Seroquel XR
Seroquel XR is to be taken orally, swallow 1 tablet whole (can be taken with water), do not break or chew. Do not take the medicine with food. Dosage of Seroquel XR depends on the purpose of treatment as follows:
Schizophrenia, bipolar disorder with moderate to severe manic episodes: 300mg/day 1, then increased to 600mg/day 2 and recommended daily dose 2. The maximum dose may be increased to 800mg/day. Depending on the response and tolerability, the dose of Seroquel XR 400-800mg/day can be adjusted to be effective. Bipolar disorder with major manic episodes: 50mg/day 1, 100/day 2, 200mg/day 3, 300mg/day 4 and recommended daily dosing 4. It is best to take Seroquel XR before bed. Dosage may be increased to 600 mg for some patients to increase effectiveness or reduced to a minimum of 200 mg if patient tolerability is concerned. Prevention of relapse of bipolar disorder: Continue taking the same dose that has responded to treatment for acute bipolar disorder to prevent recurrence of depression, mania, mania, and mixed depression. The medicine should be taken before going to bed. Depending on the patient's ability to respond and tolerate Seroquel XR, the dose should be adjusted from 300 - 800mg/day, it is best to use a low dose to bring about effective treatment. Major depressive disorder, supporting major depressive episodes: 50mg/day 1, 50mg/day 2, 150mg/day 3, 150mg/day 4, taking the drug at bedtime. It is best to use low doses for effective treatment because using high doses of the drug can increase the risk of side effects. The initial dose should preferably be 50mg/day and depending on the patient's results, increase the dose to 150-300mg/day. Generalized anxiety disorder: 50mg/day 1, 50mg/day 2, 150mg/day 3, 150mg/day 4. Depending on the patient's ability to respond to Seroquel XR, the dose should be adjusted, preferably in the range from 50 - 150mg/day, can be up to 300mg/day but should use lower dose to bring effective treatment. Elderly: Dosage adjustment is necessary in the elderly, the recommended initial dose is 50 mg/day and the total dose should be lower over time than in younger patients. Depending on the response of the patient to increase the dose gradually, each time increasing 50mg / day until the effective dose is found. It is best to use Seroquel XR at a low dose for effective treatment. Patients with renal impairment: No dose adjustment of Seroquel XR is required. Hepatic impairment: With caution in patients with hepatic impairment, the recommended initial dose is 50 mg/day. Seroquel XR, if used in excess, can cause low blood pressure and heart palpitations. An overdose may require intensive care, adequate oxygenation, airway ventilation, support, and cardiovascular monitoring. Gastric lavage and intravenous infusion may be necessary and the patient continues to be closely monitored until fully recovered.
3. Side effects of Seroquel XR
Seroquel XR medicine can cause some unwanted side effects with the following frequency:
Very common: Dry mouth, headache, dizziness, drowsiness, withdrawal syndrome, decrease in hemoglobin, decrease in HDL cholesterol , increased total cholesterol, increased serum triglycerides , weight gain; Common: Vomiting, dyspepsia, constipation, dyspnea, blurred vision, orthostatic hypotension, palpitations, tachycardia, dysarthria, appetite, hyperglycemia, mild body weakness, fever, irritability excitement, peripheral edema, increased serum transaminases and gamma-GT, changes in endocrine indices, decreased white blood cells and neutrophils, increased eosinophils ; Uncommon: Seroquel XR is less likely to cause rhinitis, dysphagia, convulsions, tardive dyskinesia, fainting, sexual dysfunction, low blood sodium, diabetes, impaired thyroid function, reactions hypersensitivity, platelets, neutrophils decreased, anemia. Rare: Pancreatitis, hepatitis, jaundice, menstrual disorders, breast swelling, lactation, erectile dysfunction, metabolic syndrome, thromboembolism, agranulocytosis, hypothermia, increased blood creatine phosphokinase. Very rare: Anaphylaxis, metabolic syndrome, Stevens-Johnson syndrome, angioedema, rhabdomyolysis. Frequency not determined: Neonatal withdrawal syndrome, erythema multiforme, necrosis often toxic. If you see any of the above symptoms after using Seroquel XR, the patient should immediately contact a pharmacist, doctor or go to a medical facility for advice and guidance.
4. Some notes when using Seroquel XR
It is possible to switch to Seroquel XR rapid-release tablets to take once a day instead of taking many times but still ensure the same dose. Seroquel XR should not be used in people with hypersensitivity to its ingredients, children under 18 years of age, patients taking antifungal drugs, HIV protease inhibitors, P450 3A4 inhibitors. Closely monitor patients with high suicidal ideation while taking Seroquel XR. If the clinical symptoms worsen, the patient behaves abnormally, intends to commit suicide, the family members and caregivers should contact the doctor for timely support and treatment. In patients with extrapyramidal symptoms such as restlessness, constant body position changes, restlessness during the first week of treatment, caution should be exercised when increasing the dose. When a patient presents with tardive dyskinesia, drug discontinuation or dose reduction should be considered, but symptoms may increase and worsen. During the use of Seroquel XR, if there is any sign of drowsiness, especially severe drowsiness, the patient should return to the doctor for instructions to improve symptoms, if not, consider discontinuing the drug. Patients should be cautious in using the drug until they are familiar with the side effects of the drug, which are orthostatic hypotension or reduce the dose in people with cardiovascular disease. It is necessary to stop taking the drug and take appropriate treatment when the patient shows signs of high fever, muscle spasticity, unstable nervous system, mental changes. Closely monitor patients who are taking Seroquel XR and have weight gain, hyperglycemia, and metabolic problems. Use caution when using seroquel xr in people with cardiovascular disease, the elderly, patients using other sedatives, people with congenital QT prolongation syndrome. If stopping the drug, it should be stopped gradually over 1 to 2 weeks to avoid withdrawal symptoms. When jaundice is observed, the drug should be discontinued. Patients at risk of aspiration pneumonia should be cautious when using the drug. Before and during administration of Seroquel XR, it is important to identify patients with risk factors for VTE in order to prepare preventive measures. People with galactose intolerance, lapp lactase deficiency should not take the drug. Limit the activities of driving, operating machinery during treatment with the drug because the drug affects the mind. Pregnant and nursing women should weigh the benefits of treatment with Seroquel XR against the potential risk to the fetus. Use caution when using Seroquel XR with alcohol and central nervous system drugs, do not use concomitantly with CYP3A4 inhibitors, carbamazepine, phenytoin. If you are taking drugs that prolong the QT interval or drugs that cause electrolyte imbalance, caution should be exercised. Use a different test technique for methadone because the drug can cause a false-positive result. In summary, the use of Seroquel XR is to restore equilibrium of the natural neurotransmitter internally for the treatment of moderate to severe manic episodes in bipolar disorder, major depressive episodes in major depressive disorder, schizophrenia, and generalized anxiety disorder.
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