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Padolgine is manufactured and registered by OPV Pharmaceutical Joint Stock Company, belonging to the group of drugs that have effects on the respiratory tract. So what is the use of Padolgine and how is it used?
1. What is Padolgine?
Padolgine medicine has the main ingredients containing the active ingredient Acetaminophen 400mg, Caffeine 50mg and Codeine phosphate hemihydrate 20mg and excipients just enough for 1 tablet. The drug is prepared in the form of film-coated tablets, packed in boxes of 10 blisters or 2 blisters, 1 blister has 10 tablets.
2. Indications and contraindications to the drug Padolgine
2.1. Indications for Padolgine Drugs Padolgine is indicated for use in the following cases:
Indication for treatment of patients with dry cough. The drug works to help relieve pain quickly in cases of headache, low back pain, muscle pain, neuralgia, body pain. Relieves minor aches and pains caused by: toothache, headache, sinusitis, muscle aches, menstrual pain, rheumatic pain, pain from the common cold. Padolgine is indicated for patients > 12 years of age for the relief of moderate acute pain when other analgesics such as Ibuprofen or Acetaminophen alone have not been effective. 2.2. Contraindications to Padolgine The use of Padolgine is not indicated for the following subjects, the contraindications here will be understood as absolute contraindications and Padolgine must not be used for any reason:
Patient Hypersensitivity to any component of the drug including the main ingredient and excipients contained in the drug Padolgine . Do not use Padolgine in patients with G6PD deficiency, patients with severe liver failure, asthma, respiratory failure, impaired liver function, anemia, renal, cardiovascular. Do not give Padolgine to children under 12 years of age or weighing less than 15 kg. Do not use for pregnant women and nursing mothers. Padolgine should not be used in patients who are carriers of the superfast CYP2D6 drug metaboliser gene.
3. How to use and dose of Padolgine
3.1. How to take Padolgine The drug Padolgine is prepared in the form of film-coated tablets, should be taken orally, when taken with a full glass of water. The drug can be taken before, during or immediately after a meal. Padolgine should not be used for pain relief in patients who have had pain for more than 5 days in children and 10 days in adults, because such severe or prolonged pain could be a sign of a medical condition that needs to be diagnosed. diagnosis and treatment. Do not use Padolgine for patients with fever lasting more than 3 days and high fever above 39.5oC, or recurrent fever. Because fever can be a sign of a serious illness, the use of fever-reducing medications can mask symptoms of illness. 3.2. Dosage of Padolgine The dose of Padolgine must be based on the age, weight, symptoms and severity of the disease of the patient, the patient must adhere to the treatment regimen prescribed by the doctor, the reference dose is as follows:
For adults and children > 12 years old: use 1 to 2 tablets once, every 6 hours (minimum 4 hours), not to take more than 8 tablets of Padolgine in 1 day.
For children under 12 years old: Padolgine is not recommended for this audience, it is necessary to use it as prescribed by the doctor and should use other drugs containing Paracetamol in smaller amounts.
4. Undesirable effects of the drug Padolgine
When using Padolgine, patients may experience side effects in addition to the main effects of the drug:
Common side effects such as headache, dizziness, thirst, nervous agitation and strange sensations, vomiting, nausea, constipation, little urination, urinary retention, slow pulse, tachycardia, weakness, palpitations, orthostatic hypotension. Less common side effects include: pruritus, urticaria, rash, restlessness, respiratory depression, stomach pain, biliary spasm, renal disease, neutropenia, thrombocytopenia, and pancytopenia. blood, anemia. Rare side effects such as: hallucinations, anaphylaxis, visual disturbances, disorientation, circulatory failure, convulsions, in the drug Padolgine contains the active ingredient Codeine, which should be used for a long time, may cause addiction. . Usually, these side effects go away when the patient stops taking Padoldine. However, during the course of treatment, if the patient experiences any adverse effects, it is necessary to immediately contact the doctor for instructions on treatment and timely treatment.
5. Padolgine drug interactions
Padolgine already contains Codeine in its composition, so do not use concomitantly with other narcotic pain relievers, this may cause respiratory depression.
The drug has a neutralizing effect on stomach acid, prolonging and slowing the absorption of oral Acetaminophen. Some drugs can change the rate of Acetaminophen such as Domperidone, Metoclopramide, Cholestyramine.
The effect of the drug Padolgine may be reduced when used together with Quinidine, specifically Quinidine deactivates Codeine, because Codeine inhibits the enzyme Cytochrome P450, so the drug can reduce the metabolism of cyclosporin. When using Acetaminophen 1 tablet daily for a long period of time, it may increase the anticoagulant effect of Coumarins and Warfarins, causing an increased risk of bleeding. The caffeine present in Padolgine can block the metabolism of Clozapine.
6. Pay attention to the use of the drug Padolgine
Should not be used with other drugs containing Acetaminophen.
Long-term use of drugs in high doses can cause damage to liver cells.
Use caution when using in subjects with a history of respiratory diseases such as bronchial asthma or drug addiction.
Padolgine drug can cause drowsiness, should be careful with subjects driving, operating machinery.
Not for use by pregnant and lactating women, children under 6 years old.
With the sharing about the drug Padolgine, hope to help you know how to use and use the drug correctly and effectively.
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