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Claminat medicine 1g is indicated for use in cases of ear, nose and throat infections such as tonsillitis, sinusitis, otitis media. Lower respiratory tract infections. On the market today, there is a lot of information about Claminat 1g drug products, but it is still incomplete. To better understand Claminat 1g and its effects, let's learn more in the article below.1. What is Claminat 1g?
Claminat medicine has the main ingredients amoxicillin 875mg (as amoxicillin trihydrate) and clavulanic 125mg (as potassium salt clavulanate). Excipients: Avicel, Ethanol 96%, Sepifilm, Aerosil, Magnesium Stearate, talc, water just enough. Amoxicillin is a penicillin antibiotic that fights bacteria in the body. Clavulanate potassium is a beta-lactamase inhibitor that helps prevent certain bacteria from becoming resistant to amoxicillin. The drug is prepared in the form of film-coated tablets manufactured by Imexpharm Pharmaceutical Joint Stock Company.Pharmacodynamics of Claminat 1g
Amoxicillin and clavulanate potassium is a combination antibiotic. Amoxicillin is a β-lactam antibiotic that fights bacteria in the body. Due to the inhibition of bacterial cell wall synthesis, amoxicillin has a broad bactericidal spectrum against many gram-positive and gram-negative bacteria. Amoxicillin is very susceptible to destruction by B-lactamases, so it has no effect on strains of bacteria that produce these enzymes.
The fermentation of streptomyces clavuligerus produces clavulanic acid with a b - lactam structure similar to that of penicillin, capable of inhibiting β - lactamase produced by most gram-negative bacteria and staphylococcus.
Pharmacokinetics of Claminat 1g
Absorption Claminate is absorbed orally, and serum concentrations of amoxicillin and clavulanic acid are maximal after 1-2 hours of dosing. Food does not affect the absorption of the drug, the best time to take it is right before a meal. The oral bioavailability of clavulanic acid is 75% and amoxicillin is 90%.
Distribution Amoxicillin is distributed in most body tissues and fluids except the brain and spinal cord. Binding to plasma proteins is low, amoxicillin is 18%, clavulanic acid 25%.
Metabolism Only partially metabolized amoxicillin, while the metabolism of clavulanic acid has not been determined.
Elimination The half-life of amoxicillin in serum is 1 - 2 hours and that of clavulanic acid is about 1 hour. Both substances are excreted in the urine in an active form, with amoxicillin about 55-75% and clavulanic acid about 30-40%.
2. What effect does Claminat 1g have?
Many people when suffering from inflammation and infections such as tonsillitis, boils, infections, genital tract infections, ... often think about what kind of medicine should be used to treat. They often wonder when buying Claminat 1g and ask if Claminat 1g is effective?With the main active ingredient is Amoxicillin, the pharmacological effects of this ingredient have shown the use of Claminat 1g. Amoxicillin is a broad-spectrum, semi-synthetic beta-lactam antibiotic with a broad spectrum of Gram-positive and Gram-negative bacteria. It acts through the mechanism of inhibiting bacterial cell wall synthesis, causing bacteria to not reproduce and be destroyed.
Beta-lactamase enzyme very easily breaks down Amoxicillin. Therefore, inactivation is effective against typical strains of bacteria that produce enzymes such as Haemophilus influenzae. Clavulanic acid is produced by natural fermentation of Streptomyces clavuligerus. Thanks to its ability to inhibit ß-lactamase produced by Gram-negative bacteria and Staphylococcus, it prevents amoxicillin from being destroyed by ß-lactamase. At the same time, the synergistic effect of amoxicillin broadens the antibacterial spectrum even against strains of bacteria that are normally resistant to amoxicillin by the enzymes they secrete.
Amoxicillin and clavulanic acid combine to create bactericidal antibiotics. Amoxicillin and clavulanate potassium are used to treat many different infections caused by bacteria, such as:
Patients with pneumonia, acute and chronic bronchitis, Ear infections, otitis media, sinusitis , People with urinary tract infections, cystitis, pyelonephritis Skin infections, boils, abscesses, insect stings or cellulitis Some other infections such as intra-abdominal infections, bacteremia medical, infection due to abortion
3. How to use Claminat 1g effectively?
3.1. Dosage – How to use Claminat 1g
The dosage of Claminat depends on many factors such as route of administration, age, body weight and renal function status, infection status and susceptibility to the drug of the causative organism.For adults and children weighing over 40kg: Total daily dose is 750mg to 3g, divided into several times
For children weighing less than 40kg: Dose from 20 to 50mg/kg / day, also divided into several times. The dropper is recommended for children under 6 months of age
What to do if a dose is missed?
Take the medicine as soon as you remember, if it is almost time for the next dose, skip the missed dose. Do not take 2 doses at the same time can cause unwanted effects.
What to do if overdose?
Symptoms such as nausea, vomiting, stomach pain, diarrhea, skin rash, drowsiness, hyperactivity and decreased urination may occur if you overdose. Seek medical attention immediately if you experience any of the above symptoms.
3.2. Warnings/notes when using Claminat 1g
You should not use Claminat if you are allergic to amoxicillin and clavulanate, or if:Have severe kidney disease or are on dialysis; History of jaundice with amoxicillin and clavulanate potassium; You are allergic to any penicillin or cephalosporin antibiotic, such as Amoxil, Ceftin, Cefzil, Moxatag, Omnicef, and others. To be on the safe side, tell your doctor if:
You have liver disease (hepatitis or jaundice); Kidney disease; Mononucleosis ; You are using any product that contains phenylalanine. Or if you have phenylketonuria (PKU) If you are pregnant or breastfeeding tell your doctor about this condition. Amoxicillin and clavulanate potassium can make birth control pills less effective. Ask your doctor about using non-hormonal birth control such as a condom, diaphragm, cervical cap, or birth control sponge to prevent pregnancy. Without a doctor's prescription, absolutely no children should use the drug.
3.3. Side effects of Claminat 1g
Call 911 or go to the nearest medical facility if you have signs of an allergic reaction to amoxicillin and clavulanate (rash, difficulty breathing, swelling of the face or throat) or a severe skin reaction (fever, pain, etc.) throat, eye burns, skin pain, red or purple skin rash with blistering and peeling).Contact your doctor or nearest medical facility immediately if you experience the following symptoms during use:
Diarrhea or bloody stools or severe stomach pain, need attention even after a few days month after the last dose; You are weak, pale or yellow, have dark urine, have a high fever or are confused; During use feel loss of appetite and upper abdominal pain; Oliguria or anuria; The skin may bruise easily or bleed easily. Some undesirable effects when taking amoxicillin and clavulanate may include:
Diarrhea or vomiting; Rash, itching, or vaginal discharge or diaper rash; The above is not a complete list of possible side effects. You need to listen to your body while taking the medicine and tell your doctor right away if you experience any unusual symptoms.
3.4. What other drugs will affect amoxicillin and clavulanate potassium?
You need to tell your doctor before starting treatment about all medicines including traditional medicine and especially drugs:Allopurinol; Probenecid; Warfarin, Coumadin, Jantoven. Within the confines of this article, there is no complete list of drugs that may interact with amoxicillin and clavulanate. It is important that you honestly list all the medications you are taking with your treating physician so he or she can be sure. the treatment that best suits your health and condition.
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