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Aliskiren is a line of renin inhibitors. The drug is used to treat hypertension, inhibits Angiotensin II and Renin Receptors. The following article Vinmec hospital will give you some information about the uses and notes when using Aliskiren.
1. What is Aliskiren?
Aliskiren is used to treat high blood pressure in adults and children from 6 years of age and with a weight of at least 50 kg. The drug contains Aliskiren and is made in the form of tablets with a strength of 150mg, 300mg.Aliskiren is contraindicated in the following cases:
Aliskiren should not be combined with ACE inhibitors or angiotensin II receptor blockers in patients with diabetes. Allergic hypersensitivity Children under 2 years old. Mid- and late-pregnant women. Idiopathic angioedema, hereditary angioedema. Angioedema when taking Aliskiren. Do not combine Aliskiren with ciclosporin and itraconazole.
2. Uses of the drug Aliskiren
Aliskiren is used to treat:
High blood pressure Helps prevent stroke Prevent heart attack Kidney disease Aliskiren works by dilating blood vessels to make it easier for blood to flow. Aliskiren belongs to the class of drugs that directly inhibit renin.
3. Aliskiren side effects
When using Aliskiren, patients may experience some of the following side effects:
Rash Difficulty breathing Swelling in the mouth, tongue, throat In addition, if you experience the following serious side effects: The patient should immediately see a doctor.
Delirium, fainting Nausea Weak pulse and irregular heartbeat Swelling around eyes Severe skin reactions, skin pain, red rash, cyanosis, skin blisters and peeling, itching Fever Sore throat Swelling in the face or tongue Burning eyes Stomach pain, diarrhea, heartburn Headache, dizziness, fatigue Back pain, joint swelling Nasal congestion, sore throat, cough However, the side effects mentioned above are not experienced by everyone. . In some cases there may be other side effects not mentioned. Please consult your pharmacist or doctor before using the drug.
4. Aliskiren overdose and treatment
In case of overdose and emergency, call 911 immediately or go to the nearest medical facility for timely treatment. Usually the symptoms of overdose will manifest as follows:
Fainting Dizziness Weak vision Nausea. In case of missed dose: Patients should take 1 dose as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take it as usual. Do not make up for a double dose if you miss a dose.
In addition, please make a list of all the medicines you have taken, so that your doctor can consider the most suitable dose for you.
5. Some notes when using Aliskiren
Drugs acting on the renin-angiotensin system reduce fetal renal function. Besides, Aliskiren can also cause illness and death to the fetus and newborn when used during the second and third trimesters of pregnancy. When pregnancy is detected, the patient should immediately stop taking Aliskiren. Concomitant use with ACE inhibitors in patients with type 2 diabetes and renal disease may increase the risk of hypotension, renal failure, and hyperkalemia. Caution should be exercised when aliskiren and hydrochlorothiazide are used in combination. Symptoms of angioedema of the face, lips, tongue, extremities, larynx, and glottis have been reported and may increase the risk of hospitalization. These symptoms may occur at any time during treatment and occur in patients with or without a history of ACE inhibitor-associated angioedema. Angioedema involving the respiratory tract, pharynx, and larynx can lead to airway obstruction and death. Stop taking Aliskiren immediately if reactions such as: chest tightness, hives, rash, itching, vomiting, abdominal pain, angioedema,... Hypotension may occur after starting treatment. therapy in patients with an activated renin-angiotensin system, including those who are volume and/or salt-depleted (eg, those taking high-dose diuretics). When using Aliskiren can cause renal failure, acute renal failure. Renal function should be monitored at regular intervals. In addition, consideration should be given to discontinuing the drug when renal function decline occurs. Hyperkalemia may occur in patients with renal impairment, diabetes mellitus and those receiving concomitant treatment with ACE inhibitors, angiotensin II receptor blockers, NSAIDs, which may increase serum potassium levels. bar. For pregnant women can harm the fetus, should not use the drug during pregnancy. There is no information available on Aliskiren distribution into breast milk. However, the use of Aliskiren in nursing women is not recommended. The drug can cause side effects such as dizziness, headache, fatigue when operating machinery. Aliskiren is a type of renin inhibitor. The drug is used to treat hypertension, inhibits Angiotensin II and Renin Receptors. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take drugs according to prescription or consult a doctor, professional pharmacist.
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