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Audenz is also known by its common name attenuated H5N1 influenza virus vaccine. Attenuvax is recommended for use in children 6 months of age and older. So what ingredients does Audenz have and how should it be used to ensure effectiveness in the treatment of the disease?
1. What is Audenz?
1.1. What is Audenz? Influenza is a respiratory disease with airborne transmission and can affect anyone. It is estimated that the flu has killed up to 50 million people regardless of skin color or race. all over the world. According to the recommendations of the World Health Organization (WHO), influenza A (H5N1) strain is the influenza strain that can cause severe illness and with the highest mortality rate.Audenz is the first and only vaccine created by the combination of 2 advanced technologies, adjuvant MF59® and cell-based antigen production. It is indicated for active immunization to prevent disease caused by the H5N1 subtype influenza A virus contained in the vaccine. Audenz is approved for use in persons 6 months of age and older at risk of exposure to the influenza A virus subtype H5N1 contained in the vaccine
Dosage form:
Injection, milky white emulsion MF59 excipients ( Audenz) 7.5 mcg/0.5mL HA of influenza virus strain H5N1 A, producing country Turkey. Each dose of Audenz may also contain residual proteins other than BP (≤ 30 mcg) including MDCK cellular protein (<3.15 mcg), MDCK cellular DNA (≤ 10 ng), polysorbate 80 (≤ 0.375 mg), cetyltrimethylammonium bromide (≤ 4.5 mcg), and ß-propiolactone (≤ 0.1 mcg). Syringe components (syringe cap, syringe, plunger/syringe stopper) are not made of natural rubber latex. 1.2. What are the side effects of Audenz? The use of adjuvant MF59® in this vaccine can enhance and extend the body's immune response by producing antibodies against mutated virus strains when entering the human body. Adjuvants from live vaccines are an extremely important part of the global pandemic response plan, as they help reduce the amount of antigens needed in the body to produce immune responses that make it easier to produce a viral load. Larger doses of the vaccine can be used for more people faster.
2. How to use the drug Audenz
Audenz is a two-dose series of vaccines. The two doses were administered intramuscularly 21 days apart.
Prepare the intramuscular dose
Shake the emulsion vial gently Withdraw 0.5 mL for adult dose or 0.25 mL for pediatric dose Store in a refrigerator, place vaccine at dark room temperature At least 15 minutes prior to administration Mix vaccine thoroughly by inverting the ampoule before each use Inject intramuscularly
Age 12 months and older: Preferably in the lateral aspect of the deltoid muscle of the upper arm 6- 11 months old: Injection in the anterolateral thigh; Do not inject the buttocks or areas where the main nerve stem may be located
3. Contraindications of the drug Audenz
Children under 6 months of age History of severe allergic reaction (eg, anaphylaxis) to any component of the vaccine or after a previous dose of influenza vaccine.
4. Notes when using Audenz
Hypersensitivity reactions: Appropriate medical supervision and treatment is required to control possible serious allergic reactions (e.g. anaphylaxis) following vaccination.
Guillain Barre syndrome: If Guillain-Barré syndrome (GBS) has occurred within 6 weeks of receiving a previous influenza vaccine, the decision to administer Audenz should be based on careful consideration of the benefits. and potential risks.
Limited effectiveness of the vaccine
Vaccination with Audenz may not protect everyone who is vaccinated. Immunocompromised people, including those on immunosuppressive therapy, may have a reduced immune response to Audenz. Also, this vaccine will not treat flu symptoms if you already have the virus. Tell your doctor if you are using a medicine or treatment that weakens the immune system, such as steroids, radiation, or cancer treatment. This vaccine may not work as well if you are also using these medicines. However, your doctor will probably still order the injection because it can provide you with some protection.
All pregnancies carry the risk of birth defects, miscarriage or other adverse outcomes. There are insufficient data on Audenz in pregnant women to inform the risks associated with the vaccine during pregnancy.
Information on the risk of influenza A (H5N1) infection in pregnant women is limited. However, pregnant women infected with pandemic H1N1 or seasonal flu have a higher risk of severe illness from influenza infection than women who are not pregnant. Pregnant women with influenza may be at increased risk for adverse pregnancy outcomes, including labor and preterm delivery.
5. Side effects of the drug Audenz
This vaccine can cause a type of serious allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor if you or your child have a rash, itching, swelling of the tongue and throat, or trouble breathing after the injection.
Adults aged 18-64 years: Pain at injection site (64%); Fatigue (25%); Headache (25%); Tinnitus (22%); Myalgia (14%). Adults 65 years of age and older: Pain at the injection site (36%); Fatigue (20%); Tinnitus (16%); Headache (16%). Children 6-17 years old: Pain at injection site (68%); Myalgia (30%); Fatigue (27%); Tinnitus (25%). Headache (22%); Anorexia (14%); Nausea (13%); Joint pain (13%) Infants and children 6 months to 5 years: Injection site pain (56%); Discomfort (30%); Drowsiness (25%); Change in eating habits (18%); Fever ≥ 38oC (16%) Other disorders:
Blood and lymphatic system disorders: lymphadenopathy Immune system disorders: Hypersensitivity reactions including angioedema and anaphylaxis Nervous system disorders: Bell's palsy, convulsions, including febrile convulsions, demyelitis, encephalitis, Guillain-Barre syndrome, neuritis, paresthesia, syncope Skin and subcutaneous tissue disorders: Urticaria, pruritus, nonspecific rash Musculoskeletal and Connective Tissue Disorders: Muscle weakness This is important information about Audenz, but is not a substitute for your doctor's advice. Therefore, before using, patients should discuss and consult carefully to have appropriate indications.
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