Uses of Zuzafox 40

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1. What is Zuzafox 40?

Zuzafox 40 has the main active ingredient Esomeprazole (in the form of Esomeprazole magnesium trihydrate) 40mg. The esomeprazole in Zuzafox 40 is an S-isomer of Omeprazole, which inhibits acid secretion by a specific mechanism of action in gastric parietal cells. Note that both the R and S isoforms of Omeprazole have similar pharmacodynamic effects.
Esomeprazole in Zuzafox 40 is a weakly alkaline substance that, when entering the acidic environment (secretory tubules of gastric parietal cells) will be concentrated and converted into an active form. The main effect of Zuzafox 40 is to inhibit the enzyme H+K+-ATPase (also known as proton pump) acid secretion under both basal and stimulated conditions.
Studies have shown that, after 5 days of oral administration of Esomeprazole at doses of 20mg and 40mg, gastric pH remained above 4 for an average of 13 and 17 hours per day, respectively, in patients with reflux. symptomatic gastroesophageal reflux. This effect of Esomeprazole is similar when administered intravenously.
When using Zuzafox 40, up to 78% of cases of reflux esophagitis were healed after 4 weeks of treatment and increased to 93% after 8 weeks of taking the drug. During treatment with Zuzafox 40, studies reported an increase in serum gastrin levels in response to a decrease in gastric acid secretion.

2. Uses of Zuzafox 40

The product Zuzafox 40 is indicated for the treatment of cases of gastroesophageal reflux disease causing esophagitis and/or severe reflux symptoms.
However, Zuzafox 40 products are contraindicated for use in the following subjects:
History of hypersensitivity to Esomeprazole, other benzimidazoles or hypersensitivity to the excipients of Zuzafox 40; Concomitant use of Zuzafox 40 with Nelfinavir is contraindicated.

3. Dosage, how to use Zuzafox 40

3.1. Dosage Recommended dose of Esomeprazole in adults:
Support for healing of esophagitis: 20 or 40mg (1⁄2 to 1 Zuzafox 40 tablet), orally once a day for 4 to 8 weeks. After that, it can be maintained at a dose of 20mg (1⁄2 Zuzafox 40 tablets), taking 1 pill a day for a period of no more than 6 months; Treatment of symptomatic gastroesophageal reflux: 20mg (1⁄2 Zuzafox 40 tablets), taken once daily for 4-8 weeks. Dosage of Esomeprazole in children 12 to 17 years old:
Short-term treatment of gastroesophageal reflux: 1⁄2 to 1 Zuzafox 40 tablet, once daily for up to 8 weeks. Esomeprazole dose for children 1 to 11 years old:
Short-term treatment of symptomatic gastroesophageal reflux disease: 10mg, taken once a day for up to 8 weeks; Heal erosive esophagitis: Children under 20kg use 10mg dose, taken once a day for 8 weeks. Children weighing more than 20kg receive 10 or 20mg doses for 8 weeks. Dosage of Esomeprazole in some special cases:
Limiting the risk of stomach ulcers caused by non-steroidal anti-inflammatory drugs (NSAIDs): 20 or 40mg, taken once a day for up to 6 months; Kill Helicobacter pylori and limit the risk of duodenal ulcer recurrence: Esomeprazole 40mg, taken once a day, combined with Amoxicillin 1000mg, taken twice a day and Clarithromycin 500mg, taken twice a day. The duration of treatment is 10 days; Increased gastric acid secretion due to Zollinger-Ellison syndrome: 40mg (1 Zuzafox 40 tablet), twice a day; Maintenance treatment after injection of Esomeprazole to prevent re-bleeding of peptic ulcers: 40mg (1 Zuzafox 40 tablet), orally once a day for 4 weeks; In cases of severe liver failure, Esomeprazole should not be used more than 20mg/day. 3.2. How to take Zuzafox 40 Patients should take Zuzafox 40 on an empty stomach, preferably 1 hour before eating; Patients should swallow Zuzafox 40 tablets whole, do not chew or crush; For patients with difficulty swallowing, Zuzafox 40 tablets can be dissolved in half a glass of water (carbonated free), then stirred until completely dissolved and taken immediately or within 30 minutes.

4. Side effects of Zuzafox 40

Common side effects of Zuzafox 40 include: Headache; Abdominal pain, diarrhea, flatulence, nausea, vomiting, constipation ... Some uncommon side effects when using Zuzafox 40: Dermatitis, itching, urticaria, dizziness, dry mouth, blurred vision ... Besides, Zuzafox 40 medicine can lead to some rare side effects such as: Allergic or hypersensitivity reactions such as angioedema, difficulty breathing and even anaphylaxis, Stevens Johnson syndrome, muscle pain ... Some adverse reactions have been reported when using Omeprazole and may occur when using Zuzafox 40 , including:
Paresthesias, drowsiness or insomnia, dizziness; Confusion (reversible), agitation, temper, depression and hallucinations; Gynecomastia; Stomatitis and gastrointestinal candidiasis; Decrease in the number of white blood cells or platelets, agranulocytosis or, more seriously, a decrease in all 3 blood cell lines; Hepatic encephalopathy in patients with a history of severe liver disease; Hepatitis with or without jaundice; Liver failure ;

5. Zuzafox 40 . Drug Interactions

Zuzafox 40 may interact with the following active ingredients:
Ketoconazole, Itraconazole; Iron salts; Digoxin; Diazepam, citalopram, imipramine, clomipramine; Phenytoin; Warfarin or other coumarin derivatives; Cisapride; Clarithromycin. Zuzafox 40 is a prescription drug, so to use it safely, patients need to follow the doctor's instructions. If you have any questions about this medicine, consult your doctor.

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