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Zlatko 50 has the main ingredient is Sitagliptin 50mg, belongs to the group of drugs to treat diabetes. Zlatko 50 is used for patients with type 2 diabetes mellitus in monotherapy or in combination with other hypoglycemic agents to control blood sugar. Knowing the basic information about ingredients, uses, and dosages will bring better treatment results.1. What is Zlatko 50?
Zlatko 50 is prepared in many forms of film-coated tablets, with the main ingredients including:
Active ingredient: Sitagliptin (as Sitagliptin phosphate monohydrate) content 50mg Excipients: Microcrystalline cellulose (Avicel 101), Lactose monohydrate, Povidon, Sodium starch glycolate, Magnesium stearate, Silicon dioxide, PEG 6000, HPMC 615, Titanium dioksid, Talc, sunset yellow, iron oxide red, iron oxide yellow. Just enough for 1 tablet. Mechanism of action
Incretin hormone in the body participates in the regulation of homeostasis of glucose levels, the main components include Polypeptide that stimulates the secretion of Glucose-dependent insulin (Glucose-dependent insulinotropic polypeptide: GIP) and Glucagon-like peptide-1 (GLP-1). Incretin hormone is released from the gut and increases in response during and after meals. The active ingredient Sitagliptin in Zlatko 50 selectively inhibits Dipeptidyl peptidase 4 (DPP-4) Enzyme that hydrolyses Incretin hormones, thereby increasing the concentration of active forms of GLP-1 and GIP (Incretin active form). ) in blood. Thereby, Sitagliptin increased insulin release and decreased Glucagon levels in a glucose-dependent manner that improved blood glucose in patients with type 2 diabetes.
2. Indications of the drug Zlatko 50
Zlatko 50 is indicated for the treatment of the following cases:
People with type 2 diabetes. Used in combination with other hypoglycemic drugs such as hypoglycemic Sulfamid, Metformin, PPAR y agonist to control blood sugar in people with type 2 diabetes.
3. Contraindications of the drug Zlatko 50
Hypersensitivity to any ingredient in Zlatko 50. History of allergy to drugs containing the active ingredient Sitagliptin. People with type 1 diabetes. People with diabetic ketoacidosis complications.
4. Dosage and how to use Zlatko 50
Note:
Take the medicine on an empty or full stomach. Renal function should be assessed prior to use 4.1. Patients with type 2 diabetes normally Recommended dose: Take 2 tablets (100 mg) / time x 1 time / day. Use as a single dose or in combination with other hypoglycemic agents such as sulphamides, metformin, and PPAR agonists. 4.2. Patients with type 2 diabetes with renal failure The drug is adjusted based on the creatinine clearance (ClCr)
Mild renal impairment (ClCr ≥ 50 mL/min)
Dose: Take 2 tablets (100mg)/time x 1 time /day Moderate renal impairment (30 ≤ ClCr < 50 mL/min)
Dose: Take 1 tablet (50 mg)/time x 1 time/day Severe renal impairment (ClCr < 30 mL/min)
Dose: Take 1/ 2 tablets (25 mg)/time x 1 time/day
5. Note when using Zlatko 50
5.1 Side effects of the drug Zlatko 50 Treatment with Zlatko 50 in high doses or for a long time, can cause side effects such as:
Common: Symptoms on the gastrointestinal tract such as indigestion, sadness vomiting, vomiting, abdominal pain, diarrhea. Respiratory symptoms such as nasopharyngitis, upper respiratory tract infection. Other manifestations such as fungal dermatitis, angioedema, headache. Uncommon: Hypoglycaemia. Should stop the drug immediately when detecting the above side effects after using Zlatko 50 and promptly notify the doctor or go to the nearest medical facility for timely treatment.
5.2 Notes on the use of Zlatko 50 in subjects The dose of Zlatko 50 should be reduced when using the drug in patients with moderate and severe renal impairment, especially in patients with end-stage renal failure requiring peritoneal dialysis. Closely monitor the patient's condition and evaluate kidney function before, during and after using the drug. People < 18 years: There are no data to confirm the safety and effectiveness of Zlatko 50 in this population. Pregnancy: The use of Zlatko 50 in pregnant women is not recommended because there are no studies to confirm safety. Lactation: There are no studies that show that the active ingredient Sitagliptin in Zlatko can pass into breast milk, so it should be used with caution when absolutely necessary. Symptoms of fatigue, drowsiness, dizziness may occur after using Zlatko 50, so drivers or workers who operate machinery should be cautious.
6. Zlatko 50 . drug interactions
Using Zlatko 50 in combination with hypoglycemic agents with Sulfamid may increase the incidence of hypoglycemia. Therefore, a reduction in the dose of Sulfamide should be considered in this case.
No dose adjustment of Sitagliptin is recommended when co-administered with Digoxin, Cyclosporin or Ketoconazole. Drugs not affected by the active ingredient Sitagliptin in Zlatko 50: Metformin. Glyburide, Rosiglitazone. Warfarin. Simvastatin. Oral contraceptives. Drugs used in combination do not affect the effect of Zlatko 50: Drugs to treat hypercholesterolemia: Statins, Flbrat, Ezetimibe. Antihypertensive drugs: ACE inhibitors, Angiotensin receptor blockers, beta blockers, calcium channel blockers, Hydrochlorothiazide diuretics. Non-steroidal anti-inflammatory drugs (NSAIDs): Naproxen, Celecoxib, Diclofenac. Antihistamines: Cetirizine. Antidepressants: Bupropion, Sertraline, Fluoxetin. Antiplatelet drugs: Clopidogrel. Drugs for male erectile dysfunction: Sildenafil The above is general information and notes when using Zlatko 50. In order to bring the best treatment effect, patients and family members should carefully read the instructions for use. on the packaging of the drug Zlatko 50, and strictly follow the indications and instructions of the treating doctor.
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