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Zentobiso 10mg drug belongs to the group of cardiovascular drugs, with the main active ingredient being Bisoprolol fumarate used in the treatment of hypertension and angina pectoris. The drug is used as prescribed by doctors, pharmacists and often used in combination with ACE inhibitors, cardiac glycosides and diuretics. Let's learn more about the effects and how to use Zentobiso through the following article.
1. What does Zentobiso 10mg do?
Zentobiso 10mg drug is used in the following cases:
Patients with mild to moderate hypertension. Treatment of stable chronic heart failure. Zentobiso can be used as monotherapy or in combination with antihypertensive drugs, diuretics, ACE inhibitors, cardiac glycosides.
2. How to use Zentobiso 10mg effectively?
2.1. How to use Zentobiso 10mg is prepared in the form of tablets, used for oral administration. 2.2. Dosage Dosage is determined individually according to heart rate and treatment outcome.
Treatment of angina and hypertension:
The usual dose is from 5 to 10 mg of Bisoprolol/day. Maximum dose: 20 mg Bisoprolol/day. Patients with impaired liver and kidney function do not need to adjust the dose. An initial dose of 2.5 mg Bisoprolol/day may be used and the dose should be adjusted accordingly. Dosage should not exceed 10 mg of Bisoprolol/day in patients with severe renal impairment with creatinine clearance < 20 ml/min or with severe hepatic dysfunction. Treatment of heart failure:
Initial dose: Take a single dose of 1.25 mg Bisoprolol/day. If the patient tolerates the drug well, the dose can be doubled after 1 week and increased gradually over 1 - 4 weeks and should not exceed 10 mg of Bisoprolol/day. In elderly patients, no dose adjustment of Bisoprolol is necessary unless significant hepatic and renal dysfunction is present. Depending on the patient's tolerance to the drug, the doctor may decide to extend the time between dose increases. If the patient's condition worsens or the patient cannot tolerate the dose, it may be necessary to reduce the dose or discontinue treatment. In some patients, the maintenance dose may be lower than 10 mg of Bisoprolol Fumarate. The doctor will tell the patient what to do. If the patient has to stop the drug completely, the doctor will advise to reduce the dose gradually, otherwise the patient's condition will worsen.
3. What to do when overdose, forget dose of Zentobiso 10mg?
In case of overdose Zentobiso 10mg may occur bradycardia, hypotension and hypoglycemia. Patients should stop using the drug immediately and treat with intravenous atropin (1 - 2 mg). If necessary, an intravenous dose of 25 mcg Isoprenaline or Glucagon can be used in doses ranging from 1 to 5 mg. If bronchospasm or heart failure occurs, it should be treated with intravenous Aminophylline, a cardiotonic (Digitalis) and a diuretic.
If you forget to take a dose, take it as soon as you remember. However, if the make up dose is close to the next dose, the patient should skip the make up dose and use the next dose as scheduled. Do not double the prescribed dose of Bisoprolol.
4. Contraindications to using Zentobiso 10mg
Zentobiso 10mg drug is not used for the following subjects:
Patients with hypersensitivity to Bisoprolol, beta blockers or other active ingredients of the drug. Shock due to decompensated heart failure. Atrioventricular conduction disorder. Sinus node disorder syndrome. Sinus atrial block. Bradycardia <50 beats/min or irregular heartbeat before starting treatment. Very low blood pressure < 90 mmHg. Metabolic acidosis. Chronic respiratory diseases, bronchial asthma, bronchitis. The patient is taking an MAO inhibitor. Peripheral circulatory disorders advanced stage. Raynaud's syndrome. Chromophilic cell tumor. Metabolic acidosis. Note:
In the case of patients with adrenal tumors, only Bisoprolol is used in combination after blockers. Precautions for patients with diabetes, long-term starvation with sharp fluctuations in glycemic index, for patients with metabolic acidosis, first-degree atrioventricular block, Prinzmetal's angina. Patients with a personal and family history of psoriasis need to carefully weigh the potential benefits against the new risks of taking the drug.
5. Zentobiso 10mg . drug interactions
Below is a list of drugs that should not be combined with Zentobiso 10mg, because drug interactions may occur.
Do not use Bisoprolol in combination with other beta-blockers. Concomitant treatment of Bisoprolol with catecholamine-depleting drugs such as: Reserpine, Clonidine, Alpha-methyldopa and Guanethidine can significantly reduce heart rate. In combination with myocardial relaxants or atrioventricular conduction inhibitors such as: Calcium antagonists, Verapamil, Diltiazem, Disopyramide, hypotension, bradycardia, arrhythmias or heart failure may occur. Rifampin increases the metabolism and elimination of Bisoprolol, requires a shortened half-life, and does not require dose adjustment of Bisoprolol. Bisoprolol used at the same time as insulin, oral hypoglycemic agents may potentiate their effects. It is important to check blood sugar levels often because the symptoms of hypoglycemia (tachycardia) are often masked or mitigated. Some drugs to treat arrhythmias such as: Quinidin, Flecainide, Disopyramid, Lidocain, Phenytoin, Propafenone. Do not use with Verapamil and Diltiazem drugs (medicines used to treat high blood pressure, angina, irregular heartbeat). Do not use with Timolol eye drops and glaucoma medications such as Tacrin and Carbachol. Isoprenalin and Dobutamine for the treatment of acute heart disease. Digoxin drug. Non-steroidal anti-inflammatory drugs: Diclofenac, Ibuprofen. The drugs Imipramine, Amitriptylin, Phenobarbital, Levomepromazine should not be used together with Bisoprolol. Mefloquine for the prevention and treatment of malaria. MAOIs such as Moclobemide except MAO-B inhibitors. Ergotamine is used to treat migraine headaches.
6. Side effects occur when taking Zentobiso 10mg
During the treatment with Zentobiso 10mg, the patient may experience some unwanted side effects such as:
Body fatigue, dizziness, dizziness, headache, sweating, sleep disturbance, anxiety, distraction, depression. These symptoms are usually less severe and should go away within 1 to 2 weeks after treatment. Digestive disorders such as: Nausea, vomiting, stomach pain, abdominal pain, diarrhea, constipation, epigastric pain, stomach ulcer,... Cardiovascular problems such as numbness and cold cold extremities, hypotension, bradycardia, or atrioventricular conduction disturbances. Skin reactions: Erythema, itching, swelling, psoriasis, hair loss...
7. Precautions when using Zentobiso 10mg
Before using the drug, the patient should carefully read the instructions for use and refer to some information below.
Do not use the drug in patients with congestive heart failure. However, in some cases, the drug must be used with caution. Abrupt discontinuation of drug therapy may exacerbate angina, ventricular arrhythmias, and myocardial infarction in patients with coronary artery disease. The drug should be stopped slowly and should be prescribed by a doctor or pharmacist. Bisoprolol should be used with caution in patients with bronchospasm and should be used at the lowest possible dose with an initial dose of 2.5 mg Bisoprolol/day. It can also be used concurrently with a beta 2 agonist. Bisoprolol should be discontinued at least 48 hours prior to surgery. Use with caution with anesthetic agents such as Ether, Trichlorethylene, Cyclopropan. Overdose is treated with Atropin 1 - 2mg I.V. Bisoprolol can mask the manifestations of hypoglycemia, tachycardia. Therefore, it should be used with caution in patients with diabetes and hypoglycemia. The use of Zentobiso 10mg during pregnancy and lactation can harm the fetus and newborn baby. Bisoprolol has not been found to be excreted in human milk, but due to the potential for bradycardia, hypoglycemia, and hypotension in the neonate. Therefore, it is not recommended to use the drug while breastfeeding. If you are pregnant or planning to become pregnant, you need to inform your doctor to decide if you can use the drug during pregnancy or not. Bisoprolol has a side effect of lowering blood pressure, so the ability to drive and use machines may be affected. This usually occurs at the beginning of medication or in an interaction with alcohol. Particular caution should be exercised when initiating treatment, changing the dose and taking it with alcohol. In addition, when using Zentobiso tablets, be especially cautious in cases of strict vegetarianism, heart disease, liver and kidney problems, asthma, chronic lung disease, history of psoriasis, disorders thyroid gland,.. need more treatment condition or perform more frequent checkups.
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