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Zensunel drug is indicated in the treatment of symptoms of osteoarthritis, acute gout, dysmenorrhea, joint pain... Let's learn about the uses and notes when using Zensunel through the article below.1. What is Zensunel?
Zensunel medicine contains the active ingredient Etodolac 200mg in the form of hard capsules. The active ingredient Etodolac belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs), acting by inhibiting prostaglandin biosynthesis of the inflammatory process through reverse inhibition of COX-1 and COX-2 enzymes, thereby helping to lower fever - pain relief - anti-inflammatory.
Zensunel is indicated in the following cases:
Symptomatic treatment of osteoarthritis, acute gout attacks or pseudo-gout; Treatment of pain after surgery, pain after tooth extraction, episiotomy; Pain relief from dysmenorrhea.
2. Dosage of the drug Zensunel
Zensunel belongs to the group of prescription drugs, the dose of medicine used is prescribed by the doctor based on the medical condition. Patients should take the drug after a meal to reduce the risk of gastrointestinal irritation, take the tablet whole, do not break or crush.
Some recommendations on the dosage of Zensunel are as follows:
Adults:
Treatment of acute pain: The recommended dose is 200-400mg every 6-8 hours, the maximum dose should not exceed 1000mg/day; Treatment of rheumatoid arthritis, osteoarthritis: The recommended dose is 400mg/time x 2 times/day or 300mg/time x 2-3 times/day, in some cases the dose can be increased to 500mg/time x 2 times/day; For the elderly: No dose adjustment is necessary, however, caution should be exercised when treating the elderly because the drug is more sensitive to anticoagulant effects. Children:
Treatment of acute pain: Limited data are available for use in children under 18 years of age. For children weighing less than 50kg, the dose is 7.5mg - 10mg/kg/time every 12 hours, the maximum daily dose should not exceed 1000mg. For children under 18 years of age weighing more than 50 kg, a dose of 300-400mg every 8-12 hours, the maximum daily dose should not exceed 1000mg. For children over 18 years of age, the dose is 200-400mg every 6-8 hours, the maximum daily dose should not exceed 1000mg.
3. Side effects of the drug Zensunel
Zensunel medicine can cause some side effects as follows:
On the digestive system: Diarrhea, constipation, indigestion, abdominal pain, nausea, vomiting, duodenitis, gastritis, intestinal ulceration, inflammation stomach...; On the nervous system: Drowsiness, drowsiness, dizziness, headache, coma, paresthesia, mental flexibility, confusion, fatigue; Skin: Sweating, angioedema, herpes, purpura, hyperpigmentation, Stevens - Johnson syndrome, maculopapular rash, erythema, peeling...; On the liver: Hepatitis, increased liver enzymes, pancreatitis, liver failure, jaundice; Systemic: Allergy, fever, chills, fatigue, anaphylactic reaction, malaise, infection; On the genitourinary system: Renal failure, dysuria, tubular necrosis, increased BUN; On blood and lymphatic system: Anemia, bruising, prolonged bleeding time...; On the respiratory system: Bronchitis, bronchial asthma, pharyngitis, shortness of breath, sinusitis... Patients need to notify their doctor if they encounter unwanted effects during treatment with Zensunel.
4. Notes when using the drug Zensunel
Contraindicated to use Zensunel in the following cases:
Patients with hypersensitivity to Etodolac or any component of Zensunel; Patients with a history of bronchial asthma, urticaria, bronchospasm, allergic reactions after treatment with Aspirin or other NSAIDs; Contraindications to the use of the drug in the setting of coronary artery bypass surgery; Patients with gastrointestinal ulcers, stomach ulcers, gastrointestinal bleeding. Caution when using:
Etodolac in particular and other NSAIDs in general increase the risk of cardiovascular thrombotic events, including stroke, myocardial infarction... This risk may occur. early and increased with duration of treatment. Zensunel may cause dizziness, drowsiness, blurred vision, and other neurological symptoms. Therefore, patients should be informed of these risks and be careful when driving or operating machinery during treatment. Zensunel increases the risk of gastrointestinal complications including ulceration - gastrointestinal perforation, stomach bleeding... Signs of bleeding include black stools, coughing up blood, vomit that looks like coffee grounds... Kidneys It is important to consider Zensunel treatment in patients with coagulopathy or on anticoagulant therapy, because the drug may prolong bleeding time. Zensunel may increase transaminases, so patients should discontinue use if clinical signs of elevated liver disease appear. Etodolac may increase blood potassium, especially in the elderly, people with diabetes, people with kidney disease and when used with drugs that increase blood potassium. NSAIDs can affect kidney function, especially in patients with dehydration, liver failure, heart failure, the elderly... Therefore, it is necessary to be cautious and monitor renal function closely during treatment. treat. Zensunel medicine can cause serious side effects on the skin, patients should stop using the drug when signs of rash or any other hypersensitivity reactions appear. The risk of meningitis is increased with Etodolac treatment, especially in patients with systemic lupus erythematosus, a mixed connective tissue disorder.
5. Drug interactions
The drug Zensunel may cause some of the following interactions:
Antacids reduce the plasma concentration of Etodolac; Concomitant use of Etodolac and Aspirin, a non-steroidal anti-inflammatory drug increases the risk of side effects; The risk of bleeding is increased with concomitant use of Etodolac and Warfarin; Etodolac concomitantly with Digoxin, Cyclosporin, Lithium, Methotrexate reduces the clearance of these drugs, increases toxicity; Do not drink alcohol during treatment with Zensunel, because alcohol increases the risk of gastrointestinal bleeding; Limit exposure to the sun and UV rays because the drug makes the skin more sensitive to sunlight, more prone to sunburn. Drug interactions occur that increase the risk of having an effect and reduce the therapeutic effect of Zensunel, so to ensure safety and effectiveness in treating patients, it is necessary to inform the doctor about the drugs and foods that are being used. used before taking Zensunel.
