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Drug Zensalbu nebules 2.5 main active ingredient is salbutamol, has a selective agonist effect on β2 receptors and bronchodilator. It is indicated for the control of severe acute asthma or chronic bronchospasm unresponsive to standard therapy.
1. Uses of zensalbu nebules 2.5
Zensalbu nebules 2.5 has the main active ingredient salbutamol, has a selective agonist effect on β2 receptors found in bronchial smooth muscle, uterine muscle, vascular smooth muscle and has very little effect on β1 receptors on cardiac muscle . Therefore, the drug has a bronchodilator effect, reduces uterine contractions and has little effect on the heart. When administered as an aerosol, the bronchodilator effect appears rapidly after 2-3 minutes. Approximately 72% of inhaled drug is excreted in the urine within 24 hours, of which 28% is unchanged and 44% is metabolized. The half-life of the drug is about 3.8 hours. Zensalbu nebules 2.5 is indicated in the following cases:
Control of chronic chronic bronchospasm unresponsive to other treatment. Treatment of acute severe asthma (severe and persistent asthma attacks not responding to standard therapy).
2. Dosage and how to use Zensalbu nebules 2.5
Dosage
Adults and Children: The appropriate starting dose of nebulized salbutamol is 2.5 mg, the dose may be increased to 5 mg. In some cases, it can be used up to 4 times a day. When treating severe airway obstruction in adults, the dose may be higher up to 40 mg/day under close hospital supervision.
The clinical efficacy of Zensalbu nebules 2.5 in children under 18 months of age is still unknown. Oxygen-supportive therapy should be considered, as transient hypoxia may occur.
How to use:
Zensalbu nebules 2.5 solution is used through a nebulizer. The drug is formulated to be used undiluted. However, if you want to prolong the drug delivery time, you can mix the drug with sterile saline. How to prepare Zensalbu nebules 2.5 and the nebulizer is as follows:
Break one ampoule of Zensalbu nebules 2.5 by turning one tube downwards and detaching it while keeping the rest of the Nebules blister firmly in place. Holding one end of the Zensalbu nebules 2.5 tube firmly, rotate the tube body to open the cap. Insert the open end of the Zensalbu nebules 2.5 tube into the solution cup of the nebulizer. Squeeze the tube of Zensalbu nebules 2.5 slowly to pour the drug solution into the cup, taking care to pour all the Zensalbu nebules 2.5 solution into the cup. Prepare the nebulizer and use it according to the instructions. After use, need to remove all excess solution in the cup of the nebulizer, clean the nebulizer according to the instructions in the machine. Patients can use a mask, a “T” device, or an endotracheal tube to deliver medication. Intermittent positive pressure ventilation (rarely needed) may be used. Oxygen should be given to the patient when there is a risk of hypoxemia due to hypoventilation. Many types of nebulizers operate on the principle of continuous aerosol, so the aerosol drug may be released into the surrounding environment. Therefore, Zensalbu nebules 2.5 should be used in a well-ventilated room, especially in a hospital when many patients are using the nebulizer at the same time.
3. Contraindications Zensalbu nebules 2.5
Contraindicated to use Zensalbu nebules 2.5 for patients with hypersensitivity to any ingredient of the drug or used to manage premature labor, threatened miscarriage, threatened premature birth.
4. Undesirable effects of the drug Zensalbu nebules 2.5
Patients using Zensalbu nebules 2.5 may experience the following side effects:
Frequency > 10%:
Nervous system: Excitement, anxiety Musculoskeletal: Tremor Respiratory: pharyngitis, inflammation nose, upper respiratory tract infections Frequency 1 to 10%:
Cardiovascular: Chest discomfort, chest pain, edema, extrasystoles, flushing, hypertension, palpitations, tachycardia Dermatology: pallor, skin rash, urticaria Endocrine and metabolic: Diabetes, hyperglycemia Gastrointestinal: Anorexia, diarrhea, dyspepsia, abdominal distension, flatulence, gastroenteritis, glossitis, nausea Genitourinary system: Dysuria, urinary tract infection Frequency <1%:
Cardiovascular: ST segment reduction on ECG Gastrointestinal: Epigastric pain, stomach pain Nervous system: Irritability, sleep disturbance Nervous system musculoskeletal: Weakness, muscle spasms Ophthalmology: Dilated pupils
5. Notes when using Zensalbu nebules 2.5
Cardiovascular disease: Use with caution in patients with cardiovascular disease.
Diabetes: Use with caution in patients with diabetes, as beta-2 agonists may increase serum glucose and worsen pre-existing diabetes and ketoacidosis.
Glaucoma: Use with caution in patients with glaucoma, as the drug may increase intraocular pressure.
Hyperthyroidism: Use caution when used for people with hyperthyroidism because the drug can stimulate the activity of the thyroid gland.
Hypokalemia: Use with caution in patients with hypokalemia, as beta-2 agonists may decrease serum potassium. Particular caution should be exercised in patients with severe asthma because the risk of hypokalemia may be increased when used with diuretics, xanthine derivatives. Serum potassium levels should be monitored closely in these patients.
Epilepsy: Use with caution in patients with seizure disorders, as the drug may lead to CNS stimulation.
Do not let solution or aerosol get into eyes
Pregnant women: Zensalbu nebules 2.5 was teratogenic in rats when administered subcutaneously at doses 14 times the human aerosol dose. There are currently no large-scale studies in pregnant women. Therefore, the drug should not be used in this population when the safety of the drug for the fetus is unknown.
Lactation: Salbutamol is excreted in small amounts into breast milk. The effect of the drug on the nursing infant has not been established, therefore caution should be exercised when administering the drug to a nursing woman. When necessary, it is necessary to weigh the benefits and risks before deciding to use.
Above is information about uses, doses and notes when using Zensalbu nebules 2.5. Patients should consult a doctor or pharmacist before use to ensure safety and effectiveness.
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