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Zencombi has the effect of relaxing the bronchial muscles, increasing the amount of air in patients with airway obstruction. Zencombi combines two drugs according to different mechanisms, so it has a synergistic effect in relaxing bronchial muscles.
1. Uses of Zencombi
Zencombi drug is prepared in the form of aerosol solution. Each 2.5ml solution contains the active ingredient Salbutamol (in the form of Salbutamol sulfate) 2.5mg; Ipratropium bromide 0.5mg. Salbutamol is a beta-adrenergic agent that selectively acts on beta receptors of the adrenergic system. The drug has effects on smooth muscle such as bronchodilator, uterine muscle relaxant. The smooth muscle relaxant effect is dose and route-dependent. This effect occurs via the cyclic adenyl cyclase-AMP system, with binding of the drug to beta-adrenergic receptors at the cell membrane causing the conversion of ATP to cyclic AMP that activates protein kinases. This leads to the phosphorylation of proteins and ultimately to an increase in the combined intracellular calcium concentration, while the decreased ionized intracellular calcium inhibits actin-myosin fibrin binding and inhibits muscle contraction. . Thus relaxes smooth muscle. Salbutamol relaxes bronchial muscles in both normal subjects and patients with asthma or chronic obstructive pulmonary disease (COPD) after oral administration. Salbutamol is probably the most potent and safe of the sympathomimetic bronchodilators, so it is commonly used.
Ipratropium bromide is an acetylcholine antagonist with a parasympathetic effect. Ipratropium is a competitive non-selective antagonist at muscarin(M) receptors in the respiratory tract and other organs. The drug relaxes the smooth muscle of the bronchi and bronchioles. Ipratropium inhaled orally has a relaxing effect on bronchial smooth muscle without affecting the secretion of mucus in the bronchial mucosa, has little effect on salivary secretion, does not dilate pupils, increases intraocular pressure. or stimulate the central nervous system.
Zencombi drug combines 2 ingredients with different mechanisms of action, both have bronchodilator effects. Thanks to that, the drug Zencombi is used in the treatment of reversible bronchospasm associated with obstructive airway disease, bronchial asthma.
2. Usage and dosage of Zencombi
How to use: The drug is prepared in the form of aerosol solution. Separate nebulizer equipment is required to make this solution into small particles that can penetrate deeper into the respiratory tract. Note that when aerosols need to take deep and slow breaths through the mouth to allow the solution to enter the respiratory tract. In addition, after use, it is necessary to clean thoroughly to avoid contamination of aerosol tools, wash before implementation.
Dosage:
Adults and children > 12 years old: Acute bronchospasm is used with a single dose of 1 ampoule/time, if necessary, 2 single dose tubes can be used. Maintenance dose: Use 1 ampoule of single dose each and every day about 3-4 times / day, each dose is spaced at least 4 hours. 3. Side effects when taking Zencombi Some side effects that may occur when taking the drug include:
Headache, dizziness, restlessness, slight musculoskeletal tremor. Tachycardia, palpitations. Note when using the drug Zencombi
Zencombi drug should not be used in cases such as hypertrophic obstructive cardiomyopathy, tachyarrhythmias. Hypersensitivity to any of the excipients and a history of hypersensitivity to atropine or derivatives. The drug should be used with caution in patients with cardiovascular disease (coronary artery insufficiency, arrhythmia and hypertension); hyperthyroidism ; diabetes. Pregnancy: Although there is no evidence that the drug is teratogenic, if absolutely necessary, the drug should only be used after carefully weighing the benefits and risks. Lactation: It is not known whether Zencombi is excreted in human milk. Because of the tumorigenic potential of the drug observed in animal studies, a decision must be made whether to discontinue nursing or to continue the drug. Drug interactions may occur when used with the following drugs xanthine derivatives, beta-blockers, MAOIs, inhaled anesthetic tricyclic antidepressants. This medicine should only be used under the direction of a doctor. If after taking the medicine at home, but the shortness of breath due to bronchospasm does not improve, you need to stop the medicine and go to a medical facility immediately. Hopefully, through this article you have had basic information about Zencombi drug. Always use the medicine under the prescription of the doctor to ensure safety for health.
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