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Bromhexin Actavis® is a drug used in the treatment of respiratory pathologies, in patients with increased sputum production causing airway obstruction. So what is Bromhexin Actavis and how is it used?
1. What is Bromhexin Actavis?
Bromhexin Actavis medicine has the main ingredient of Bromhexin hydrochloride 8mg, which is prepared in the form of tablets packed in a box of 1 blister x 20 tablets.
Pharmacodynamics of bromhexine hydrochloride:
Bromhexin is a synthetic preparation, which is a derivative of benzylamine. Chemically, bromhexin is a vasicine alkaloid analog, isolated from the plant Adhatoda vasica. Bromhexin hydrolyzes and cuts the polymer chains of mucoproteins in bronchial secretions; stimulates synthesis of neutral polysaccharides from epithelial glands. It has pronounced lysosomal activity, liquefying thick bronchial secretions, thereby facilitating easier expectoration and improving respiration. Bromhexin has the effect of increasing the secretion of exocrine glands (including the lacrimal glands) and enhancing the production of surfactant of the lung epithelium. Bromhexin enhances the penetration of some antibiotics into the bronchial mucosa, increases the concentration of the antibiotics in the bronchial secretions and thereby facilitates more effective action of the antibiotics. Some antibiotics are effective such as ampicillin, amoxicillin, oxytetracycline, erythromycin, cephalexin. The major metabolite of bromhexine hydrochloride is ambroxol hydrochloride with similar activity and pharmacological activity. Pharmacokinetics of bromhexine hydrochloride:
Absorption: Following oral administration, bromhexine is very well absorbed from the gastrointestinal tract and reaches peak plasma concentrations within 1 hour. The average duration of action is 6 hours after a single dose. Following a single dose of 4 mg of bromhexine, plasma concentrations at 8 hours were 0.14 μg/ml and 24 hours were 0.5 μg/ml, respectively. Distribution: Bromhexine hydrochloride is widely distributed into body tissues. The drug binds very strongly (95% - 99%) to plasma proteins. Metabolism: Bromhexine is metabolized mainly by the liver. Most of the drug is excreted in the urine as metabolites. To date, 10 metabolites of bromhexine hydrochloride have been identified in plasma, of which ambrosol is an active metabolite. Elimination: The half-life of the drug is about 6.5 hours. 70-88% of the dose is excreted unchanged in the urine after 5 days. Approximately 4% of the dose is excreted in the feces.
2. What are the uses of Bromhexin Actavis?
Bromhexin Actavis has the effect of expectorant, expectorant, making it easier for patients to expectorate. Bromhexin Actavis enhances mucus transport by reducing the viscosity of mucus and hydrolysing mucoproteins leading to depolarization of mucopolysaccharides, severing these macromolecular fibers, and modulating secretory cell activity. mucus. This changes the structure of the mucus and reduces its stickiness. Actavis Bromhexin is indicated in the treatment of respiratory diseases with increased phlegm secretion and symptoms of difficulty in expectoration of phlegm such as acute and chronic bronchitis, chronic respiratory inflammation, pneumoconiosis, bronchiectasis. , chronic obstructive pulmonary diseases .
3. How to use and dose of Bromhexin Actavis?
Dosage of Bromhexin Actavis in adults and children over 12 years old is 8mg x 3 times/day. The dose of Bromhexin Actavis in children 6-12 years old is 4mg x 3 times/day. Dosage of Bromhexin Actavis in children 2 - 6 years old: 4mg x 2 times/day. Patients must read the leaflet carefully before using the drug. If there is anything unclear about taking your medicine, ask your doctor or pharmacist. For the drug B romhexin Actavis, take the drug after eating, drinking with enough water. Do not use Bromhexin Actavis for longer than 8-10 days without consulting your doctor.
In case the patient uses an overdose of Bromhexin Actavis, causing abnormal symptoms, stop taking the drug immediately and contact the nearest medical facility to assess the condition and handle it promptly.
In case the patient forgets to take a dose, take the medicine as soon as you remember it as soon as possible. However, if it is too close to the next dose, skip the missed dose and take your next dose at the scheduled time. Note: Do not take a double dose to replace the missed dose.
4. Bromhexin Actavis can not be used in any cases?
Bromhexin Actavis drug is contraindicated in the following cases:
People with hypersensitivity to any component of the drug Bromhexin Actavis. Not recommended for pregnant women, but if necessary the doctor can also prescribe.
5. Interaction of Bromhexin Actavis with other drugs
If Bromhexin is used in combination with antibiotics, it will increase the concentration of antibiotics in lung and bronchial tissues, so to increase effectiveness in the treatment of respiratory infections, Bromhexin Actavis is often used in combination with antibiotics.
Avoid combination with antitussives or atropine bronchodilators.
6. What are the side effects when using Bromhexin Actavis?
Patients may appear symptoms such as dry mouth, stomach pain, nausea, vomiting and digestive disorders when using the drug. Therefore, in the process of using the drug for treatment, if there are any unusual side effects, the patient should immediately notify the doctor or pharmacist.
7. Precautions when using Bromhexin Actavis
Avoid the combined use of Bromhexin Actavis with cough suppressants, because there is a risk of sputum stagnation in the respiratory tract due to the inability to loosen sputum. Use caution when using the drug for people with asthma, because Bromhexin can cause bronchospasm in some susceptible cases. Use caution when using Bromhexin Actavis in people with severe liver and kidney failure. Use caution when using the drug for patients with debilitated body, weak body and unable to expectorate sputum. Caution in patients with a history of gastric ulcer to avoid undesirable effects. Caution should be exercised when using the drug in pregnant or lactating women. Although the drug does not have a sedative effect causing drowsiness, it still needs to be used with caution when driving and operating machinery. Bromhexin Actavis® is a medicine used in the treatment of respiratory diseases, in patients with increased sputum production causing airway obstruction. To ensure effective treatment and avoid unwanted side effects, patients need to take the drug exactly as directed by a doctor or pharmacist.
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