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Zanimex 500mg is used to treat upper respiratory tract infections such as otitis media, sinusitis, lower respiratory tract infections and exacerbations of chronic bronchitis. To learn more about Zanimex 500mg, let's learn more in the article below.1. What is Zanimex 500mg?
Zanimex 500 has the main ingredient is the antibiotic cefuroxime. The drug is used to treat ear - nose - throat infections, lower respiratory tract infections, urinary tract infections - genitals, skin - soft tissue infections caused by strains of bacteria that are still sensitive to the drug. In addition, Zanimex is also indicated in uncomplicated gonorrhea.
1.1. Dosage form of the drug Zanimex 500mg Zanimex 500 is prepared in the form of film-coated tablets and packaged in a box of 2 blisters x 15 tablets.
1.2. Ingredients of the drug Zanimex 500 mg Each film-coated tablet contains: Cefuroxim 500 mg Excipients: Aerosil, Sodium starch glycolate, Sodium carboxymethyl cellulose, Sodium lauryl sulfate, Tablettose 80, Magnesium stearate, Hydroxypropyl methylcellulose, Macrogol 6000, Plasdone , Talc, Titanium dioxide, Ethanol 96% and Ion Exchange Water.
1.3. Pharmacodynamics of the drug Zanimex 500mg Cefuroxime is a semi-synthetic broad-spectrum antibiotic belonging to the cephalosporin group. Cefuroxime has antibacterial activity against many common pathogens, including beta-lactamase-producing strains of Gram-positive and Gram-negative bacteria.
1.4. Pharmacokinetics of the drug Zanimex 500mg Cefuroxime is absorbed from the gastrointestinal tract after you take it. Cefuroxime is widely distributed throughout the body. The drug crosses the blood-brain barrier when the meninges are inflamed. The drug also crosses the placenta and is excreted in breast milk. Maximum serum concentrations are reached about 2 - 3 hours after oral administration with a meal. The serum half-life is from 1 to 1.5 hours. Cefuroxime is not metabolized and is eliminated unchanged by glomerular filtration and tubular secretion.
2. What are the uses of Zanimex 500mg?
Uses of the drug Zanimex 500mg include:
Treatment of ear, nose and throat infections: otitis media, sinusitis, tonsillitis, pharyngitis. Treatment of lower respiratory tract infections: pneumonia, acute bronchitis and exacerbations of chronic bronchitis. Treatment of skin and soft tissue infections: impetigo, pyoderma, boils. Treatment of urinary tract infections - genitourinary: cystitis, nephritis - pyelonephritis, urethritis. Uncomplicated gonorrhea. Treatment of early Lyme disease manifested by symptoms of erythema caused by Borrelia burgdorferi, bone and joint infections, bacteremia. Treatment of meningitis caused by susceptible bacteria.
3. Contraindications of Zanimex 500mg
Zanimex 500 is contraindicated for use in the following cases:
Hypersensitivity to cephalosporin antibiotics and drug components. For patients who are sensitive to penicillin antibiotics, you should consider the possibility of cross-allergic reactions.
4. Side effects of Zanimex 500 mg
Undesirable effects caused by Cefuroxime are usually mild and only last for a short time.
Common: diarrhea and maculopapular rash. Uncommon: nausea, vomiting, eosinophilia, leukopenia, urticaria, pruritus, anaphylactic reactions and candidiasis. Rarely include: hemolytic anemia, pseudomembranous colitis, cholestatic jaundice, acute renal failure and interstitial nephritis. Possible drug interactions such as:
Ranitidine, sodium bicarbonate will reduce the bioavailability of cefuroxime. Cefuroxime should be administered at least 2 hours after antacids or H2-receptor blockers, as these may increase gastric pH. High-dose probenecid also reduces renal clearance of cefuroxime, resulting in higher and more prolonged serum cefuroxime concentrations. Aminoglycosides or potent diuretics increase the likelihood of nephrotoxicity. Cefuroxime can affect the microflora in the intestine, reducing the reabsorption of estrogen. Therefore, the drug can reduce the effect of oral drugs containing estrogen and progesterone.
5. How to use Zanimex 500mg effectively?
5.1. Usage Duration of treatment is from 10 to 14 days.
It is recommended to take pms-Zanimex with meals to increase bioavailability. Swallow the tablet whole and do not chew it as it has a bitter taste.
5.2. Dosage of the drug Zanimex 500mg Adults:
Most Infections 250 mg x 2 times/day and Typhoid fever 500 mg x 2 times/day; Urinary-genital infections 125mg x 2 times/day Mild to moderate lower respiratory tract infections: 250mg/time x 2 times/day; severe, suspected pneumonia: 500mg/time x 2 times/day; Pyelonephritis dose: 250mg/time x 2 times/day; Uncomplicated gonorrhea, a single dose of 1 g. Lyme disease in the early stages: 500mg x 2 times / day, for 20 days. Children
Most Infections 125mg/time x 2 times/day and up to 250mg/time; Typhoid fever dose: 250mg/time x 2 times/day; Children 2 years and older with otitis media or serious infections 250mg/time x 2 times/day. Note: The above dosage is for reference only. The specific dose will depend on the condition and the progression of the disease. To get the right dose, you need to consult your doctor or medical professional immediately.
5.3. Treatment of overdose when taking Zanimex 500mg Acute overdose: Mostly causes nausea, vomiting, diarrhea and in addition can cause increased muscle excitability and convulsions, especially in people with renal failure.
6. Be careful when using Zanimex 500mg
Pseudomembranous colitis has been reported with broad-spectrum antibiotics, so this diagnosis should be taken into account in patients with severe antibiotic-associated diarrhea. This drug should be used with caution in patients with gastrointestinal disease, especially colitis.
Prolonged treatment with cefuroxime may increase the proliferation of non-susceptible organisms. Careful monitoring of patients is required. If a serious superinfection occurs during treatment, the drug must be discontinued.
Zanimex 500mg should be stored at 30°C, protected from moisture and light. The shelf life of the drug is approximately 36 months from the date of manufacture.
Hopefully, the above sharing will help you get more information about Zanimex as well as how to use it to achieve high efficiency.
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